Clinical trials: Cholesterol, HDL
Dyslipidemias, Cardiovascular Risk Factor
Meta-analyses of Soy Protein and Its Food Sources for Cholesterol Reduction
Although soy protein has approved health claims in Canada and the US, and is recognized by major cardiovascular clinical practice guidelines for the reduction of cholesterol and risk of coronary heart disease (CHD), these claims…
- Conditions
- Dyslipidemias, Cardiovascular Risk Factor, Dysglycemia
- Trial name
- NCT04861545
- Testing
- Soy
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Acute Coronary Syndrome
Function of High Density Lipoproteins in Acute Coronary Syndromes
High density lipoproteins (HDL) have many effects that protect against cardiovascular diseases. In an acute heart attack (acute coronary syndrome -ACS), HDL change in composition and structure, reflecting the inflammatory…
- Trial name
- HDL_ACS (NCT01278875)
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Metabolic Syndrome, Insulin Resistance
The Effects of the Telomerase Activator TA-65 on Insulin Resistance, Inflammation, and Metabolic Syndrome
Our hypothesis is that TA-65, a dietary supplement will help to reduce insulin resistance and plasma glucose in individuals classified with metabolic syndrome.
- Trial name
- NCT01753674
- Testing
- TA-65
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Rheumatoid Arthritis
Effects Of CP-690,550 (Tasocitinib) On Cholesterol Metabolism In Patients With Active Rheumatoid Arthritis
The purpose of study is to explore the effect of CP-690,550 (tasocitinib) on cholesterol metabolism in patients with active rheumatoid arthritis (RA).
- Trial name
- NCT01262118
- Testing
- CP-690,550 (tasocitinib)
- Where
- 11 sites in United States, Hungary
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Pfizer
Coronary Artery Disease
Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective…
- Trial name
- HERCET (NCT00457379)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Cholesterol, Cholesterol (total and HDL)
Natural Heart Health Supplement Trial
We are running a 3-month trial of an experimental natural heart health supplement. Participants will take a daily dose of an experimental natural heart health supplement in powdered format, chocolate flavor.
- Trial name
- NCT06671769
- Testing
- Heart Health Supplement
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Low HDL Cholesterol
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals
This is a study of HDL function in healthy individuals classified in three groups according to their HDL-cholesterol levels (Low HDL-C, Intermediate HDl-C and High HDL-C), with the purpose of investigating which characteristics…
- Trial name
- NCT02106013
- Where
- Brazil
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Weight Change, BMI
Childhood Obesity Prevention Project in Gran Canaria
Given the alarming rates of obesity and overweight in our child population, the investigators have developed an intervention strategy, based on a multidisciplinary, school-centered approach, which addresses nutritional education…
- Conditions
- Weight Change, BMI, Activity Level, Cholesterol (total and HDL)
- Trial name
- POI (NCT06607159)
- Testing
- Implementation of healthy habits teaching protocol
- Where
- Spain
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Universitario Insular Materno Infantil
Metabolic Syndrome, Osteoporosis
Exercise and Flax-Based Nutritional Supplementation for Lowering Cholesterol
The purpose of our study is to use a flaxseed-based nutritional supplement in combination with exercise training (walking) for improving cholesterol levels.
- Trial name
- NCT00204412
- Testing
- Flax lignan, Exercise (walking)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Sexual Dysfunction, Hyperlipidemia
Treatment of Hyperlipidemia and Sexual Dysfunction
Hyperlipidemias are frequently associated with and are considered an important cause of erectile dysfunction in men. This association has been attributed to the impairment of blood flow through endothelium-dependent relaxation in…
- Trial name
- NCT00923676
- Testing
- fenofibrate, Rosuvastatin, fenofibrate + rosuvastatin
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Cardiovascular Diseases
Study of the Effectiveness and Safety of Niaspan ® in the Treatment of Lipid Abnormalities in Latin America
Post-Marketing Observational study of Niaspan® tablet in accordance with each country regulations. This study will be conducted in a prospective, single-arm, multi-center format.
- Trial name
- NCT01200160
- Testing
- Niacin
- Where
- 22 sites in Colombia, Mexico and 1 more
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Abbott
Dyslipidemia
Resveratrol and Serum Apo A-I
Although much effort has been done to lower LDL-cholesterol concentrations, there is still a substantial risk for cardiovascular disease (CVD). Another strategy to lower the risk for CVD is elevating the HDL-cholesterol (HDL-C).
- Trial name
- NCT01364961
- Testing
- Resveratrol capsules
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cholesterol, HDL, Lipid Metabolism, Inborn Errors
Mendelian Reverse Cholesterol Transport Study
The purpose of this study is to investigate the use of radiolabeled particulate cholesterol administered intravenously in association with albumin, as a method to study reverse cholesterol transport (RCT) in people carrying…
- Conditions
- Cholesterol, HDL, Lipid Metabolism, Inborn Errors, Tangier Disease, LCAT Deficiency
- Trial name
- NCT01782027
- Testing
- 3H-cholesterol bound to albumin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cardiovascular Diseases, Lipid Disorder
SRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic Outcomes
Dairy consumption has shown associations with decreased incidence of cardiometabolic diseases. With the growing interest in plant-based eating, and the mounting evidence for the cardiovascular benefits of plant forward diets…
- Conditions
- Cardiovascular Diseases, Lipid Disorder, Metabolic Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT05637866
- Testing
- Soy milk
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Secondary Hypogonadism
The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups
The study is designed to answer the following questions: 1. Is there any difference between the compositions of the HDL cholesterol subpopulations of patients with hypogonadism and the healthy controls. 2.
- Trial name
- NCT01454011
- Testing
- Testosteron 250mg injection, Testosterone 50mg transdermal application
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Lipids
Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects
In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week…
- Trial name
- NCT02549144
- Testing
- Low fat/cholesterol diet, High fat/cholesterol diet
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Hypercholesterolemia, Cardiovascular Risk Factor
The Effect of Psyllium Fibre on LDL-C, Non-HDL-C, and Apolioprotein-B: A Systematic Review and Meta-analysis
Serum cholesterol is a major modifiable risk factor for cardiovascular disease, which despite considerable reduction in prevalence, remains the leading cause of premature mortality worldwide.
- Trial name
- NCT03346733
- Testing
- Psyllium Fibre
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HDL Cholesterol, Preeclampsia
Identifying HDL Composition and Function in Preeclamptic and Normal Pregnancies
The study is design to assess if there is a correlation between diagnosis of preeclampsia and its severity to changes in HDL quality, in terms of composition and function and to determine whether preeclampsia-induced changes in…
- Conditions
- HDL Cholesterol, Preeclampsia, Saliva
- Trial name
- NCT02554604
- Where
- 2 sites in Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Cardiovascular Diseases
Effect of the Antioxidant Micronutrients of Rapeseed Oil on the Prevention of Cardiovascular Diseases (Optim'Oils)
The purpose of this study is to assess the effect of optimized oil (enriched with micronutriments) on the prevention on cardiovascular diseases.
- Trial name
- NCT00852735
- Testing
- Rapeseed Oil (prevention of cardiovascular diseases)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand