Clinical trials: Cardioembolic Stroke
Ischemic Attack, Transient, Stroke
Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke
This study evaluates the use of Colchicine in adults over 40 years of age who have suffered an ischaemic stroke or transient ischaemic attack NOT caused by cardiac embolism or other defined causes.
- Trial name
- CONVINCE (NCT02898610)
- Testing
- Colchicine
- Where
- 145 sites in Belgium, Canada and 12 more
- Volunteers
- 3,154 people
- Sponsor
- University College Dublin
Ischemic Stroke, Transient Ischemic Attack
Eliquis Acute Stroke Safety Evaluation
Study Design: This is an investigator-initiated prospective, open label, single arm phase IV study. Patients with documented non-valvular atrial fibrillation (AF) with acute TIA (defined as acute focal neurological deficits, with…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Atrial Fibrillation
- Trial name
- EASSE (NCT04435418)
- Testing
- Apixaban
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Atrial Fibrillation
Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a prevalence of 1-2%. Without antithrombotic treatment, the annual risk of a cardioembolic event is 5-6%.
- Trial name
- PRAGUE-17 (NCT02426944)
- Testing
- NOAC, Left atrial appendage closure
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic
Cardioembolic Stroke, Multidisciplinary Communication
A Real-world Registry Study of Multidisciplinary Collaborative Diagnosis and Treatment Model for Cardioembolic Stroke
Study Title: A real-world registry of multidisciplinary collaborative diagnosis and treatment models for cardioembolic stroke Research Objectives: ① Main objective: To establish a multidisciplinary assisted diagnosis and…
- Trial name
- CSMDT (NCT05498909)
- Testing
- Multidisciplinary joint diagnosis and treatment mode
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Xiao Huang
Ischemic Stroke
Low-dose Aspirin Therapy in Patients With Ischemic Stroke and Microbleeds
The purpose of this study is to investigate the safety and efficacy of low-dose (50mg) aspirin as a secondary prevention drug in patients with Non-Cardioembolic Ischemic Stroke accompanied by cerebral microbleeds.
- Trial name
- AIM (NCT04504864)
- Testing
- low-dose aspirin, conventional-does aspirin
- Where
- 6 sites in China
- Volunteers
- 400 people
- Sponsor
- Xijing Hospital
Ischemic Stroke
Cardio-embolic Stroke and Blood Bio-markers
Brain is a productive source of variety of enzymes and any brain injury like stroke to brain tissue could similarly result in an increase in these enzymes in cerebrospinal fluid and serum.
- Trial name
- NCT03927872
- Testing
- blood biomarkers
- Volunteers
- 96 people
- Sponsor
- Wafaa Samir
Ischemic Stroke, Atrial Fibrillation
Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting up to 10% of the elderly. Ischemic stroke is the main complication of AF and cardioembolism is one of the leading causes of ischemic stroke…
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Cerebrovascular Disorders, Brain Diseases
- Trial name
- CARE-AF (NCT06954610)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke
Long-term Cardiac Monitoring After Cryptogenic Stroke (CMACS)
Atrial fibrillation (AF) is a common and treatable cause of ischemic stroke, but it can be paroxysmal and asymptomatic, and therefore difficult to detect.
- Trial name
- CMACS (NCT00932425)
- Testing
- Cardionet Mobile Cardiac Outpatient Telemetry (MCOT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Stroke, Atrial Fibrillation (AF)
Clinical Relevance of Microbleeds In Stroke
Study I: CROMIS-2 (AF) Prospective cohort study of patients anticoagulated after cardioembolic stroke An observational inception cohort study (n=1425) of patients throughout the United Kingdom (UK) - (79 hospitals) started on…
- Conditions
- Stroke, Atrial Fibrillation (AF), Intracerebral Haemorrhage (ICH)
- Trial name
- CROMIS-2 (NCT02513316)
- Where
- United Kingdom
- Volunteers
- 2,490 people
- Sponsor
- University College, London
Ischemic Stroke, Cardioembolic Stroke
Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography
Rationale: Cardiac CT acquired during the acute stroke imaging protocol (acute cardiac CT) has recently been shown to have a superior diagnostic yield than transthoracic echocardiography, which is currently the most commonly used…
- Conditions
- Ischemic Stroke, Cardioembolic Stroke, Thrombus; Embolism, Left Atrial Thrombosis
- Trial name
- MtH-DETECT (NCT06585228)
- Testing
- Cardiac Computed Tomography, Transesophageal echocardiography, Repeated Cardiac Computed Tomography
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ischemic Stroke, Atrial Fibrillation
Lixiana Acute Stroke Evaluation Registry
Study Design: Lixiana Acute Stroke Evaluation Registry (LASER) is a randomized controlled trial with an associated registry. Patients with previously known or newly diagnosed atrial fibrillation (AF) and acute ischemic stroke…
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Hemorrhagic Transformation Stroke
- Trial name
- LASER (NCT03494530)
- Testing
- Edoxaban 60 MG, Edoxaban 30 mg
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Cardioembolic Stroke, Atrial Fibrillation
Left Atrial Appendage Closure With SentreHeart Lariat® Device
The study cohort will consist of up to 50 patients who are candidates for Left Atrial Appendage (LAA) closure in whom oral anticoagulation is contraindicated.
- Trial name
- Lariat (NCT02681042)
- Testing
- Left atrial appendage closure, SentreHeart Lariat®
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor Research Institute
Stroke, Cerebral Infarction
Antiplatelet Therapy to Prevent Stroke in African Americans
The African-American Antiplatelet Stroke Prevention Study is designed to prevent recurrent strokes by administration of aspirin or ticlopidine.
- Trial name
- NCT00004727
- Testing
- aspirin, ticlopidine
- Where
- United States
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Prevention of Thromboembolic Events, Atrial Fibrillation
A Study to Learn How the Study Treatment Asundexian Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body in Participants With Mild or Moderate Reduction of Liver Function Compared to Participants With Normal Liver Function
Researchers are looking for a better way to prevent the formation of blood clots in people who have or have had: an irregular and often rapid heartbeat a blocked blood flow to the heart a blocked or reduced blood flow to a part…
- Conditions
- Prevention of Thromboembolic Events, Atrial Fibrillation, Acute Myocardial Infarction, Non-cardioembolic Ischemic Stroke
- Trial name
- NCT05419635
- Testing
- Asundexian (BAY2433334)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayer
Ischemic Stroke
A Study to Evaluate the Efficacy and Safety of Renexin CR in Patients With Acute Non-cardioembolic Ischemic Stroke
A study to Evaluate the Efficacy and Safety of Renexin CR in patients with Acute Non-cardioembolic Ischemic Stroke
- Trial name
- NCT05445895
- Testing
- Renexin CR 200/160mg, Plavix 75mg
- Where
- South Korea
- Volunteers
- 483 people
- Sponsor
- SK Chemicals Co., Ltd.
Cerebral Microbleeds, Stroke
Cilostazol vs. Aspirin in Acute Non-cardioembolic Stroke With Cerebral mIcrobleeds
The purpose of this clinical trial is to demonstrate that cilostazol is non-inferior to aspirin in terms of efficacy and safety for the secondary prevention of stroke in patients with acute non-cardioembolic ischemic stroke who…
- Trial name
- NCT06530537
- Testing
- Cilostazol, Aspirin
- Where
- China
- Volunteers
- 848 people
- Sponsor
- Zhejiang Provincial People's Hospital
Ischemic Stroke
The Diagnosis Value of Serum Marker in Stroke Associated With Nonvalvular Atrial Fibrillation.
The purpose of this study is to evaluate the diagnostic value of serum NT - proBNP in stroke associated with nonvalvular atrial fibrilltion.
- Trial name
- CE (NCT02181374)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke
A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a blood clot travelled to the brain in people who within the last 72 hours had: an acute stroke due to a blood clot that formed outside the…
- Conditions
- Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack
- Trial name
- OCEANIC-STROKE (NCT05686070)
- Testing
- Asundexian (BAY2433334)
- Where
- 741 sites in United States, Argentina and 35 more
- Volunteers
- 12,327 people
- Sponsor
- Bayer