Clinical trials: Cardiac Death
Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction
Cell Therapy in Diabetic Patients With ST-Segment Elevation Myocardial Infarction(STEMI)
The purpose of this study is to investigate the efficacy and mechanism of bone marrow mononuclear cells (BMMNC) transplantation for diabetic and non-diabetic patients with ST-segment elevation myocardial infarction (STEMI)who…
- Conditions
- Left Ventricular Function Systolic Dysfunction, Left Ventricular Function Diastolic Dysfunction, Death, Myocardial Reperfusion Injury
- Trial name
- NCT01307371
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
Sudden Cardiac Arrest, Sudden Cardiac Death
Tampere Coronary Artery Disease and Sudden Cardiac Arrest Study
The goal of this observational study is to recognize clinical and genetic risk factors for sudden cardiac arrest (SCA) and death (SCD) in patients with coronary artery disease (CAD).
- Conditions
- Sudden Cardiac Arrest, Sudden Cardiac Death, Sudden Cardiac Death Due to Cardiac Arrhythmia, Coronary Arterial Disease (CAD)
- Trial name
- CADSCA (NCT06804499)
- Where
- Finland
- Volunteers
- 4,000 people
- Sponsor
- Tampere Heart Hospital
Sudden Cardiac Death, Cardiac Arrhythmias
Cardiovascular Pre-participation Screening in Children and Adolescents
Sports participation is strongly encouraged in children and adolescents, but intense training at early ages may reveal hidden heart conditions that increase the risk of sudden cardiac death.
- Trial name
- NCT07862504
- Testing
- Pre-participation clinical evaluation, Diagnostic Test: Resting 12-lead electrocardiogram, Diagnostic Test: Step test (Harvard step test)
- Where
- Brazil
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Myocardial Infarction, Ventricular Tachycardia
MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators
Implantable cardioverter-defibrillators (ICD) are currently recommended for the primary prevention of sudden cardiac death (SCD) in patients with a remote (>6 weeks) myocardial infarction (MI) and a low (≤35%) left ventricular…
- Conditions
- Myocardial Infarction, Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death
- Trial name
- SMART-DEF (NCT06269692)
- Testing
- MRI screening, Implantable Loop Recorder, Implantable Cardioverter Defibrillator
- Where
- France
- Volunteers
- 1,812 people
- Sponsor
- Central Hospital, Nancy, France
Decompensation, Heart, Decompensation; Heart, Congestive
Inpatient Mortality Prediction Algorithm Clinical Trial (IMPACT)
Through the mapping of retrospective patient data into a discrete multidimensional space, a novel algorithm for homeostatic analysis, was built to make outcome predictions.
- Conditions
- Decompensation, Heart, Decompensation; Heart, Congestive, Death
- Trial name
- IMPACT (NCT03212534)
- Testing
- Patient mortality prediction
- Where
- United States
- Sponsor
- Dascena
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Ventricular Tachycardia, Ventricular Fibrillation
DF4 Connector System Post-Approval Study
The purpose of this study is to evaluate long-term performance of the DF4 Connector System. This evaluation is based on the number of DF4 lead-related complications occurring during the study compared to the number of leads…
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death, Heart Failure
- Trial name
- NCT01638897
- Where
- 78 sites in United States, Canada and 1 more
- Volunteers
- 1,778 people
- Sponsor
- Medtronic
Arrhythmia, Heart Arrest
Public Access Defibrillation (PAD) Community Trial
To measure survival to hospital discharge of patients with out-of-hospital cardiac arrest in community units (e.g., apartment or office buildings, gated communities, sports venues, senior centers, shopping malls) served by…
- Conditions
- Arrhythmia, Heart Arrest, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00004560
- Testing
- defibrillator
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Death, Sudden, Cardiac
ASSURE WCD Clinical Evaluation - Conversion Efficacy Study
A multicenter single arm open label evaluation of the ASSURE Wearable Cardioverter Defibrillator (WCD) defibrillation waveform in adult cardiac patients
- Trial name
- ACE-CONVERT (NCT04132466)
- Testing
- Defibrillation using the ASSURE wearable cardioverter defibrillator therapy delivered via a waveform delivery test system
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- Kestra Medical Technologies, Inc.
Syncope, Bradycardia
Registry of Device Implantation
The implantable device therapy for cardiac arrhythmias has been an established therapy, and one of the common standard procedures in cardiac clinical practice.
- Conditions
- Syncope, Bradycardia, Tachycardia, Sudden Cardiac Death
- Trial name
- NCT03360227
- Testing
- implantation of cardiac devices
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
The primary objective is to compare the efficacy of the treatment using implantable cardioverter defibrillator (ICD) implantation to that of the treatment using amiodarone in the primary prevention of all-cause mortality in…
- Conditions
- Chagas Cardiomyopathy, Non-sustained Ventricular Tachycardia, At Least 10 Points in Rassi Risk Score for Death
- Trial name
- CHAGASICS (NCT01722942)
- Testing
- ICD implantation, amiodarone hydrochloride
- Where
- 20 sites in Brazil
- Volunteers
- 1,100 people
- Sponsor
- InCor Heart Institute
Death, Sudden, Cardiac, Ventricular Fibrillation
PREVENTION-ACHD Risk Score
Sudden cardiac death (SCD) is one of the major causes of mortality in adults with congenital heart disease (ACHD). Risk stratification for sudden cardiac death in this patient group is challenging and at the current moment there…
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Ventricular Tachycardia, Congenital Heart Disease
- Trial name
- PREVENTIONACHD (NCT03957824)
- Testing
- PREVENTION-ACHD risk score
- Volunteers
- 783 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heart Failure, Sudden Cardiac Death
Longitudinal Surveillance Registry
Boston Scientific CRM's Longitudinal Surveillance Registry (LSR) will serve as an active ongoing source of updated information on the long-term reliability and performance of BSC commercially available leads and LATITUDE-enabled…
- Trial name
- LSR (NCT00636272)
- Volunteers
- 2,500 people
- Sponsor
- Boston Scientific Corporation
Death, Sudden, Cardiac, Ventricular Fibrillation
Automatic External Defibrillation Monitoring in Cardiac Arrest
We propose to randomize automatic external cardioverter/defibrillators (AECD) in patients who are at high risk for life-threatening abnormal heart rhythms (arrhythmias) and are admitted to the telemetry ward, all other treatments…
- Conditions
- Death, Sudden, Cardiac, Ventricular Fibrillation, Tachycardia, Ventricular
- Trial name
- NCT00382928
- Testing
- Defibrillation of pulseless VT/VF by AECD
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Foundation for Atlanta Veterans Education and Research, Inc.
Chronic Heart Failure
Primary Prevention of Sudden Cardiac Death (PREV-DEATH)
The efficacy of implantable cardioverter-defibrillators (ICD) in primary prevention of sudden cardiac death (SCD) is well demonstrated but pivotal studies have been published more than 10 years ago and implantation's conditions…
- Trial name
- PREV-DEATH (NCT02894580)
- Where
- France
- Volunteers
- 336 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Sudden Cardiac Death
S-ICD Implantation: US Based Pilot Study
This trial investigates two key aspects of the S-ICD implantation process. 1) For S-ICD implantation a pre-operative x-ray-based assessment of the anatomy and location of the heart is required.
- Trial name
- SUSTAIN S-ICD (NCT06771700)
- Testing
- Intraoperative PRAETORIAN Score
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Köln
Cardiac Sudden Death, Hypoxia Brain
New Biomarkers of Neurological Outcome After a Sudden Cardiac Death
The aim of the project is to establish the value of circulating microparticles as a new biomarker for neurological prognosis of patients recovered from sudden cardiac death who remain comatose.
- Conditions
- Cardiac Sudden Death, Hypoxia Brain, Cell Membrane Microparticles, Biomarkers
- Trial name
- NCT03962361
- Testing
- Concentration of circulating microparticles.
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Heart Failure, Systolic
Patient and Physician Survey Determinants of Appropriate ICD Utilization
To better understand the reasons for underutilization of defibrillator therapy in selected populations, the investigators propose a study to assess heart failure patient knowledge and attitudes toward device therapy.
- Trial name
- NCT01514773
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Todd M Koelling, MD
Lupus Erythematosus, Systemic, Atrioventricular Block
Systemic Lupus Erythematous and Heart Conduction Disorders
Connective tissue diseases have been related to heart conduction disorders. The anti-Ro/SSA antibodies are thought to have a pathogenic role, and they most prevalent in systemic lupus erythematous (SLE).
- Conditions
- Lupus Erythematosus, Systemic, Atrioventricular Block, Sudden Death
- Trial name
- NCT02162992
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 151 people
- Sponsor
- Germans Trias i Pujol Hospital