Clinical trials: Cardiac Complication
Vital Sign Monitoring, Post Operative Complications
Continuous Vital Sign Monitoring Versus Routine Spot-checks in Patients After Non-cardiac Surgery
The "COME ON, NOW!" trial is a randomized, single-center trial in patients recovering from non-cardiac surgery on normal wards investigating whether continuous vital sign monitoring - compared to routine spot-checks by nurses …
- Conditions
- Vital Sign Monitoring, Post Operative Complications, Non-cardiac Surgery, RCT
- Trial name
- COME ON NOW (NCT07385092)
- Testing
- Unblinded continuous vital sign monitoring, Blinded continuous vital sign monitoring
- Where
- Germany
- Volunteers
- 264 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Lupus Nephritis, Diastolic Dysfunction
Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis
This cross-sectional observational study aims to investigate the correlation between echocardiographic parameters of left ventricular diastolic dysfunction (E/A ratio, e', E/e' ratio, LAVI, and LVEF) and systemic inflammatory…
- Conditions
- Lupus Nephritis, Diastolic Dysfunction, Systemic Lupus Erythematosus, Heart Failure, Diastolic
- Trial name
- NCT07837544
- Volunteers
- 90 people
- Sponsor
- Assiut University
Acute Kidney Injury
Neutrophil Gelatinase Associated Liocalin in Predicting AKI in Coronary Artery Disease
The aim of this work is to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI in patients exposed to PCI.
- Trial name
- NCT03266367
- Testing
- Neutrophil gelatinase-associated lipocalin (NAGL)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertension, Chronic Kidney Disease.
Effect of Eplerenone in Elderly Hypertensive Early Stage Chronic Kidney Disease (CKD) Patients
The purpose of this study is to determine whether eplerenone is effective in the treatment of blood pressure, heart function, renal function in elderly hypertensive stage1 (eGFR>=90ml/min/1.73m2) and stage2 (eGFR…
- Trial name
- NCT01302236
- Testing
- Eplerenone
- Sponsor
- Jichi Medical University
Postoperative Pain, Coronary Artery Bypass Grafting
Serratus Anterior Plane and PECS II Blocks After Coronary Artery Bypass Grafting
This prospective randomized placebo-controlled trial was designed to evaluate the effects of ultrasound-guided bilateral pectoralis (PECS II) and serratus anterior plane (SAP) blocks on postoperative recovery in adult patients…
- Trial name
- NCT06793436
- Testing
- Bilateral Serratus Anterior Plane Block, Bilateral PECS II Block
- Where
- Turkey (Türkiye)
- Volunteers
- 243 people
- Sponsor
- Yuzuncu Yil University
Hyperalgesia, Opioid Use
Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy.
- Conditions
- Hyperalgesia, Opioid Use, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT03450161
- Testing
- Fentanyl dosing schemes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Chronic Renal Disease
Biomarkers of Cardiovascular Complications in Chronic Kidney Disease
Identification of new retention solutes associated with cardiovascular (CV) toxicity in Chronic Kidney Disease (CKD) patients will help to better understand the pathophysiological mechanisms at stake and to prevent CKD-associated…
- Trial name
- BioClaCK (NCT03274921)
- Testing
- Biological determination
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Toulouse
Radiation Exposure, Vascular Access Complication
Randomized Comparison of Radiation Exposure in Coronary Angiography Between Right Conventional and Left Distal Radial Artery Approach
Randomized comparison of radiation exposure in coronary angiography between right conventional and left distal radial artery approach
- Conditions
- Radiation Exposure, Vascular Access Complication, Radial Artery Injury
- Trial name
- DOSE (NCT04023838)
- Testing
- artery puncture and coronary angiography
- Volunteers
- 100 people
- Sponsor
- Chonnam National University Hospital
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
The aim of this study is to identify existing definitions and therapeutic approaches for acute right ventricular injury (RVI) in patients receiving extracorporeal membrane oxygenation (ECMO) for respiratory support.
- Conditions
- Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- NCT05948332
- Testing
- Delphi Rounds to generate consensus opinions among Experts
- Where
- United Arab Emirates
- Volunteers
- 52 people
- Sponsor
- Prashant Nasa
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Surgical Site Infection
The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries.
- Trial name
- PREVTAROLINE (NCT02307006)
- Testing
- Ceftaroline, Cefazolin / Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Acute Kidney Injury, IHD
The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography
an interventional study to measure the possible effects of spironolactone ( an aldosterone antagonist) on the incidence of acute kidney injury after coronary angiography
- Conditions
- Acute Kidney Injury, IHD, Contrast-induced Nephropathy
- Trial name
- NCT03329443
- Testing
- Spironolactone
- Where
- Iraq
- Volunteers
- 490 people
- Sponsor
- Alhasan Mujtaba Abdul-Wahid
Postoperative Pain
Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）
This national, multi-center, randomized controlled study, through the study of intravenous injection of estaketamine in elderly patients undergoing surgery, is expected to explore whether estaketamine can improve the acute…
- Trial name
- NCT07063108
- Testing
- Esketamine hydrochloride, Saline
- Volunteers
- 276 people
- Sponsor
- Chinese PLA General Hospital
Complication of Cardiac Defibrillator
Health Economic Evaluation of Remote Follow up for Implantable Cardioverter Defibrillator (ICD) Patients
The purpose of the study is to define the economic value of implantable cardioverter defibrillator (ICD) remote monitoring for hospitals, third payers and patients in Italy.
- Trial name
- TARIFF (NCT01075516)
- Where
- 6 sites in Italy
- Volunteers
- 209 people
- Sponsor
- Abbott Medical Devices
Heart Failure With Preserved Ejection Fraction (HFPEF)
HFpEF Phenotyping With Echo, Clinical, and Biomarkers
The EPIC-HFpEF registry is a nationwide Italian study that follows people with a specific type of heart failure called HFpEF. About 500 patients will be enrolled from several specialized hospitals and monitored for up to two…
- Trial name
- The EPIC-HFpEF (NCT07642921)
- Volunteers
- 500 people
- Sponsor
- University Of Perugia
Coronary Heart Disease, Acute Myocardial Infarction
Twenty-year Follow-up of the Inter99 Cohort
Being born small increases your risk of developing Type 2 diabetes (T2D) with age. Furthermore, data even suggest that some of the diseases ("complications") in the eyes, kidneys, nerves, liver, blood vessels and heart often seen…
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, Cardiovascular Diseases, Type 2 Diabetes
- Trial name
- NCT05166447
- Where
- Denmark
- Volunteers
- 4,000 people
- Sponsor
- Bispebjerg Hospital
Polyvascular Disease, Atherosclerosis
Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis
Аn international, multicenter, non-interventional real-life clinical practice Register studying the Actual therapeutic patient population with Multifocal Atherosclerosis in the Russian Federation and Eurasian countries
- Conditions
- Polyvascular Disease, Atherosclerosis, Atherosclerosis Generalized, Cardiovascular Diseases
- Trial name
- KAMMA (NCT05189847)
- Where
- Russia
- Volunteers
- 3,059 people
- Sponsor
- Eurasian Association of Therapists
Complications Due to Coronary Artery Bypass Graft, Graft Failure
Patency-Coronary Trial
Heart bypass surgery is used to increase blood flow to the heart. This surgery is usually done using a heart-lung machine (on-pump surgery) allowing the surgeon to perform the procedure on a still heart.
- Trial name
- PATENCY (NCT01414049)
- Testing
- On-pump CABG, Off-pump CABG
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Gestational Hypertension, Hypertension in Pregnancy
A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk Reduction in the Postpartum Period of Hypertensive Pregnancies (HP)
This trial is a pilot-scale, single institution randomized, placebo-controlled trial to assess the feasibility, acceptability, and efficacy of administering dapagliflozin for cardiovascular risk reduction in the postpartum…
- Conditions
- Gestational Hypertension, Hypertension in Pregnancy, Pre-Eclampsia, Superimposed Pre-Eclampsia
- Trial name
- DAPA-HP (NCT06785116)
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)
This is a Randomized, Single-blind, Multi-center, Placebo-controlled, Phase 2a clinical trial of BX-001N to prevent patients from Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and subsequent Major Adverse Kidney Events…
- Trial name
- NCT07164833
- Testing
- BX-001N Experimental group 1, BX-001N Experimental group 2
- Where
- 8 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Bilix Co.,Ltd.
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