Clinical trials: Cardiac Arrest, Out-Of-Hospital
Injury
Better First Aid With First Aid Training and Dispatcher Central Instructions?
The study evaluates the effect of a first aid course on first aid skills compared to no training. The study also evaluates the effect of first-aid instructions given by emergency dispatch central over mobile phone on first aid…
- Trial name
- NCT02391922
- Testing
- First aid course, First aid instructions by mobile phone
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tromso
Cardiac Arrest, Out-Of-Hospital, Hypotension and Shock
BCG Biosensor and Non- and Invasive Monitoring During Emergency Medicine Cases, a Prospective Feasibility Study
In a out of hospital emergency medicine study the investigators will measure hemodynamic effects of implemented treatments for patients with cardiac arrest, hypotension, and intensive care transports.
- Trial name
- NCT04891380
- Testing
- LUCAS 2 Active Decompression 2, Hypotension, Intensive care transport
- Where
- Norway
- Volunteers
- 183 people
- Sponsor
- Oslo University Hospital
Out-Of-Hospital Cardiac Arrest
Accuracy of EEG Slow Wave Activity in Predicting Favourable Outcome in Patients With Hypoxic Brain Injury - A Substudy of STEPCARE Trial
This is an observational substudy embedded in the STEPCARE Trial. The study involves EEG analysis, covered by the ethics approval of STEPCARE Trial.
- Trial name
- PROPEASTEPCARE (NCT06564675)
- Testing
- C-Trend Index
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 300 people
- Sponsor
- University of Helsinki
Out-of-hospital Cardiac Arrest (OHCA)
Cerebral Near Infrared Spectroscopy in Out-of-Hospital Cardiac Arrest and Neurological Prognosis
Out-of-hospital cardiac arrest (OHCA) prognosis remains poor : 7% of patients surviving without neurological impairment. 65% of patients dying after hospital admission were neurologically impaired.
- Trial name
- NISOHCA (NCT06972329)
- Testing
- Cerebral Near infrared spectroscopy (NIRSc).
- Where
- 6 sites in France
- Volunteers
- 542 people
- Sponsor
- Central Hospital, Nancy, France
Out-Of-Hospital Cardiac Arrest
AMSA and Amiodarone Study in Cardiac Arrest
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA).
- Trial name
- MOSAIC (NCT04997980)
- Testing
- Amiodarone Injection
- Where
- 4 sites in Italy, Norway and 1 more
- Volunteers
- 629 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Out-of-hospital Cardiac Arrest (OHCA)
Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore.
The goal of this clinical trial is to learn the feasibility of equipping the volunteer community responders (VCR) with the mobile external automated defibrillators (mAEDs) for the management of adults experiencing out-of-hospital…
- Trial name
- NCT07042061
- Testing
- Mobile external automated defibrillator
- Volunteers
- 1,000 people
- Sponsor
- Singapore General Hospital
Healthy Participants, Knowledge Acquisition
Learning Cardiopulmonary Resuscitation in the School Setting: RCP-KNOW Project.
Title: Out-of-hospital cardiorespiratory arrest and learning cardiopulmonary resuscitation in the school setting: evidence synthesis. CPR-KNOW PROYECT.
- Conditions
- Healthy Participants, Knowledge Acquisition, Cardiopulmonary Resuscitation (CPR), Children
- Trial name
- RCP-KNOW (NCT07292532)
- Testing
- Cardiopulmonary Resuscitation Teaching Intervention in Children
- Where
- 2 sites in Spain
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Cardiac Arrest, Cardiopulmonary Resuscitation
Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).
The management of out-of-hospital cardiac arrest is complex and multifactorial. With an incidence between 5 and 15 per 10,000 (46,000 patients per year in France) and a survival rate of only 5% to 15%, the room for improvement…
- Trial name
- CILICA-HS (NCT03817892)
- Testing
- Guidance of the External Chest Compression, Rhythm of a relay 4 minutes
- Where
- 11 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Caen
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.
The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition…
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Positive End-expiratory Pressure (PEEP), Ventilation During Resuscitation
- Trial name
- Lazarus-PEEP (NCT06939335)
- Testing
- Disposable PEEP Valve set at 5 cm H20., Controle
- Where
- 7 sites in Belgium, France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Ghent
Cardiac Arrest, Coma
GLP-1 Analogs for Neuroprotection After Cardiac Arrest
Experimental studies and previous clinical trials suggest neuroprotective effects of GLP-1 analogs in various degenerative neurological diseases, and in hypoxic brain injuries in experimental designs.
- Trial name
- GLIP1 (NCT02442791)
- Testing
- Byetta (Lilly, Exenatide), 20% Human Albumin
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Jesper Kjaergaard
Cardiac Arrest, Sudden
AED Log Analysis of 19 Cases in Out-of-hospital Environment
The study performed to demonstrate a reasonable assurance of safety and effectiveness of the Heart Guardian HR-501 when used in an out-of-hospital environment.
- Trial name
- NCT03969797
- Testing
- RADIAQBIO Heart Guardian HR-501
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- RadianQbio
Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR)
The AIR-CPR Study: AI-Guided Chest Compressions
The AIR-CPR project aims to improve survival rates for patients with Out-of-Hospital Cardiac Arrest (OHCA) by utilizing Artificial Intelligence (AI) to optimize chest compression locations.
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR), Aortic Valve Compression, Precision Resuscitation
- Trial name
- AIR-CPR (NCT07431710)
- Testing
- Device: AI-Enhanced Arterial Waveform Monitor (AIR-CPR App), AI-Guided Chest Compression Repositioning, Transesophageal Echocardiography (TEE)
- Where
- Taiwan
- Volunteers
- 255 people
- Sponsor
- Far Eastern Memorial Hospital
Intubation Complication, Cardiopulmonary Arrest
IntuBrite Versus Macintosh for Endotracheal Intubation in Out of Hospital Cardiac Arrest
a randomized, parallel, non-blinded trial in a single Emergency Mdeical Service in Poland within a group of 34 ground ambulances crews, comparing time and first pass success (FPS) for endotracheal intubation (ETI) in DL using the…
- Trial name
- NCT05607836
- Testing
- IntuBrite intubation, Macintosh laryngoscope
- Where
- Poland
- Volunteers
- 86 people
- Sponsor
- Medical University of Lodz
Out-Of-Hospital Cardiac Arrest
Epidemiology, Management, Prognosis and Medical Cost Analysis of IHCA and OHCA
The study is a retrospective analysis of Taiwan national health insurance in cardiac arrest patients. The factors related to the outcomes of cardiac arrest patients were analyzed.
- Trial name
- NCT03684616
- Testing
- Statin
- Where
- Taiwan
- Volunteers
- 100,000 people
- Sponsor
- National Taiwan University Hospital
Out-Of-Hospital Cardiac Arrest
REmote COnditioning in Out-of-Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia.
- Trial name
- RECO-OHCA (NCT06306625)
- Testing
- Remote ischemic conditioning, No remote ischemic conditioning
- Where
- 14 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Arrest
Effects of Laryngeal Tube Ventilation on no Flow Time During Out of Hospital Cardiac Arrest
International recommendations stress on the importance of no flow time reduction in cardiac arrest management. In fact, no flow time is an independent factor of morbidity and mortality.
- Trial name
- FLOWERS (NCT01295749)
- Testing
- laryngeal tube ventilation and continuous chest compression
- Where
- 2 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble
Cardiac Arrest, Heart Arrest
ECPR for Refractory Out-Of-Hospital Cardiac Arrest
In the U.S. alone, over 300,000 people per year have sudden out-of-hospital cardiac arrest (OHCA), and less than 1 out of 10 survive.
- Conditions
- Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest
- Trial name
- EROCA (NCT03065647)
- Testing
- Expedited Transport With Mechanical CPR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Cardiac Arrest, Ventricular Fibrillation
The OSIRIS ECPR Trial
The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest
- Trial name
- OSIRIS (NCT06805344)
- Testing
- Extracorporeal cardiopulmonary resuscitation based approach, Conventional cardiopulmonary resuscitation
- Volunteers
- 686 people
- Sponsor
- General University Hospital, Prague
Cardiac Arrest With Successful Resuscitation
Hemodynamic Optimization Through Pleth Variability Index for OHCA
Less than half of the patients suffering from sudden cardiac arrest arrive at the hospital alive. Within these survivors less than half will be discharged alive from the hospital without being severely disabled.
- Trial name
- HemOpt-PVI (NCT03841708)
- Testing
- Pleth variability index, Standard non invasive monitoring
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Stefano Malinverni, MD
Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
Compression-Only Versus Standard Basic Life Support Training in Nursing Students
Survival after out-of-hospital cardiac arrest rarely exceeds 10%, and cardiopulmonary resuscitation (CPR) started by bystanders is a key factor for survival.
- Trial name
- NCT07915778
- Testing
- BLS and AED Training With Rescue Breaths, BLS and AED Training Without Rescue Breaths
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya