Clinical trials: Cardiac Ageing
HIV
Strength Training and Endurance Exercise for LIFE
Research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with HIV. This problem is of great importance to the VA.
- Trial name
- STEEL (NCT02101060)
- Testing
- exercise
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Chronic Heart Failure, Aging
Comparing the Effects of Combining Cognitive and Physical Exercise Training on Cognition, and Cerebral Blood Flow Regulation in Men and Women With Chronic Heart Failure
The objective of this project is to assess the effects of combined physical exercise and cognitive training interventions on cognitive and brain health in patients with heart failure (HF).
- Trial name
- ReCARDIO (NCT04970888)
- Testing
- Cognitive training, Exercise training, Usual care
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Montreal Heart Institute
Cardiomyopathy, Coronary Artery Disease
Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly
The overall aim of this trial is to study the safety and efficacy of ICD implantation as a primary prevention strategy of sudden cardiac death in patients 70 years and older.
- Conditions
- Cardiomyopathy, Coronary Artery Disease, Congestive Heart Failure, Myocardial Infarction
- Trial name
- I-70 (NCT02121158)
- Testing
- Implantable Cardioverter Defibrillator, Optimal Medical Therapy
- Where
- 5 sites in United States
- Volunteers
- 167 people
- Sponsor
- VA Office of Research and Development
Healthy
Japan Central Aortic Pressure Prospective Study
Purpose of the study 1. The predictive value of central aortic pressure and aortic pulse wave velocity (PWV) in a Japanese population is not known.
- Trial name
- J-CARP (NCT01243840)
- Where
- Japan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Yoshio Matsui
Atherosclerosis, Cardiovascular Disease
Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)
The prevalence, incidence, and severity of atherosclerotic disease all markedly increase with age. Basic experimental and observational data demonstrate that aging magnifies the pathologic and clinical consequences of established…
- Conditions
- Atherosclerosis, Cardiovascular Disease, Vascular Diseases
- Trial name
- NCT00246493
- Where
- 2 sites in United States
- Volunteers
- 495 people
- Sponsor
- National Institute on Aging (NIA)
Aging, CAD
Exercise and Low-Dose Rapamycin in Older Adults With CAD:Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial
The investigators will do the study in two phases. The first phase will be a pilot study on up to 18 participants [patients 60 years or older with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI)…
- Trial name
- CARE (NCT01649960)
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Alzheimer Disease, Aging
Vanderbilt Memory and Aging Project
This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults.
- Conditions
- Alzheimer Disease, Aging, Aged, 80 and Over, Biomarkers
- Trial name
- VMAP (NCT05372159)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
Aging, Alzheimer Disease
Heart Rate and Breathing Effects on Attention and Memory
In the current study, we will examine how daily paced breathing affects plasma amyloid beta levels and the rate of learning in older adults.
- Conditions
- Aging, Alzheimer Disease, Age-related Cognitive Decline
- Trial name
- HeartBEAM (NCT05602220)
- Testing
- Brain training, Paced breathing
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Ageing
Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly.
- Trial name
- CardiacAging (NCT02791139)
- Testing
- Cardiovascular Magnetic Resonance Imaging (MRI), Echocardiography, Tonometry
- Where
- Singapore
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Chronic Obstructive Pulmonary Disease, Heart Failure
Health in Smart Rurality: Impact on Coordination of Care of Telemonitoring and Data Centralization of Frailty Patients
Chronic diseases are frequent (around 10% of the total population and 30% after 60 years) and accelerate age-related functional decline.
- Trial name
- HIS2R (NCT04866550)
- Testing
- Data collection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Université de Reims Champagne-Ardenne
Aging, Heart Failure
Stair Descending vs. Stair Ascending Exercise
The aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.
- Conditions
- Aging, Heart Failure, Sarcopenia
- Trial name
- NCT01673958
- Testing
- Exercise
- Where
- Cyprus
- Volunteers
- 12 people
- Sponsor
- European University Cyprus
Aortic Valve Stenosis
OUTcomes Evaluation of Current Therapeutic STrategies for Severe Aortic Valve steNosis anD the agING Population in ITALY
In 2015 the Italian Ministry of Health invited the Cardiac Research Hospitals of Italy to constitute a Cardiac Network. The aim of the network is to facilitate and promote scientific and technological research in the setting of…
- Trial name
- OUTSTANDING (NCT05778773)
- Testing
- TAVR (Transcatheter Aortic Valve Replacement), AVR (Aortic Valve Replacement)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Policlinico S. Donato
Aging
Effect of a Motivational Intervention on Exercise Adherence After Cardiac Rehabilitation
The Canadian Physical Activity Guidelines recommend that adults should exercise for at least 150 minutes per week. Incorporating 150 minutes of moderate-to-vigorous intensity physical activity (MVPA) a week has been associated…
- Trial name
- IMREADAP (NCT04806841)
- Testing
- Motivational intervention, Control intervention
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Louis Bherer
HIV Associated Polyneuropathy
Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in…
- Trial name
- NCT07822932
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Bivalirudin in Elderly Patients Undergoing Elective Percutaneous Coronary Intervention.
The study is an investigator-sponsored, prospective, multicenter, randomized, open-label study designed to compare efficacy and safety between bivalirudin and heparin in elderly patients with acute coronary syndrome undergoing…
- Conditions
- Acute Coronary Syndrome, Percutaneous Coronary Intervention, Aging, Anticoagulants and Bleeding Disorders
- Trial name
- NCT04046029
- Testing
- Bivalirudin, Heparin
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Cardiovascular Diseases, Non-communicable Disease
Effects of Primary Prevention in Elderly People-The Healthy Aging Initiative
The number of elderly will increase rapidly in Europe in the next 30 years, which affects the country's economic and social development, welfare, health care, and also the individuals.
- Trial name
- HAI (NCT03312439)
- Testing
- Given advice
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Aging
The Effect of Long Duration Exercise on the Diastolic Function of the Heart
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for 2 years in sedentary middle aged men and women (ages 45-64) will improve cardiac and vascular compliance to a degree equivalent to…
- Trial name
- PEP (NCT02039154)
- Testing
- Aerobic and strength training group, Balance and flexibility group
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Aging, Premature, Congenital Heart Disease
White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
The study aims at investigating the role of cyanotic congenital heart disease (cCHD) on brain aging. The investigators assume that due to congenital and acquired cardiovascular abnormalities, cCHD patients could show radiologic…
- Conditions
- Aging, Premature, Congenital Heart Disease, White Matter Hyperintensities
- Trial name
- NCT03487302
- Testing
- Brain MRI, Neuropsychological test battery
- Where
- Italy
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Atrial Fibrillation Recurrent, Aging
Investigating the Effects of a Museum Intervention on the Psychological and Cardiac Health of Older Adults
In a recent report, the World Organization for Health provided some evidence that artistic and cultural activities can support the health and well-being of the population.
- Trial name
- HeART-BRAIN (NCT06130358)
- Testing
- Experimental: Well-being intervention followed by classic intervention, Experimental: Classic intervention followed by well-being intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Myocardial Infarction, Aging
Physical Activity Intervention in ELderly Patients With Myocardial INfarction
Elderly patients presenting with myocardial infarction (MI) are the highest risk population with the worst prognosis. No trial has ever been designed to optimize their outcome through a systematic improvement of their physical…
- Trial name
- PIpELINe (NCT04183465)
- Testing
- Health Education, Multi-domain lifestyle intervention
- Where
- 7 sites in Italy
- Volunteers
- 512 people
- Sponsor
- University Hospital of Ferrara