AgeingCardiacAgingNCT02791139
Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
An observational study of Ageing, run by National Heart Centre Singapore at 1 site in Singapore.
Trial summary
The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and… Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Ageing
- What is being tested?
- Cardiovascular Magnetic Resonance Imaging (MRI), Echocardiography and Tonometry
- How many people
- 800 participants
- Where
- 1 siteSingapore
- Study dates
- Jul 2014to Apr 2017
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: 600 ageing participants randomly chosen from a current pool of about 5290 surviving cohort participants in the Singapore Chinese Health Study will be recruited. 200 Healthy Volunteers control group
Who may be able to join
- Who were younger than 60 years at recruitment
- Had been interviewed at baseline and at the two follow-up interviews
- Had provided biospecimens for research previously before the age of 65 years (2000-2004)
- Who will be 65 years or older by 2013
Who cannot join
- Any known history of heart disease or stroke
- Anticipated life expectancy < 1 year
- Unable to provide written informed consent to participate in the study
- Patients with cancer
- Patients with chronic renal disease
- Any metallic implants
Trial locations and contacts
1 site in 1 country.
Su-Mei Angela Koh, MBBS contact
Singapore1 site, 1 recruiting
- Recruiting
National Heart Centre Singapore
Singapore, Singapore, 169609
Angela Su-Mei Koh, MBBS, angela.koh.s.m@nhcs.com.sg
About this study
The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.
Read the detailed description
This proposal will investigate how midlife factors in diet and lifestyle affect various aspects of cardiac structure and function related to ageing. The investigators plan to conduct the study among a sub-cohort of 600 participants from the Singapore Chinese Health Study. Comprehensive information on diet and lifestyle factors had been collected at recruitment and updated in two subsequent follow-up interviews. Candidate nutrition-related blood biomarkers such as vitamins D, homocysteine, fatty acids (short, medium and long-chain) and lipids (LDL, HDL, triglycerides) will be analyzed from samples obtained between 1999 and 2004. The investigators will study effects of smoking, alcohol consumption, sleep duration, physical activity and diet on cardiac ageing. The investigators will study overall dietary pattern, intake of specific items such as fatty acids, soy food, coffee and tea beverages, from validated food frequency questionnaires (FFQ), and nutrients from questionnaire information from this cohort previously obtained.
These nutrient and lifestyle factors will be studied individually, and for their joint or interactive effects on cardiac ageing measurements. Quantitative cardiac ageing-related outcome parameters describing cardiac mass, systolic and diastolic function, and vessel distensibility will be examined by cardiac magnetic resonance imaging. Maximum oxygen uptake (VO2 max) will be calculated based on age, gender, waist circumference, resting heart rate, and exercise habits. Body composition will be analysed by a body composition analyser machine onto which subjects stand on.
- Conditions
- Ageing
- Being tested
- Cardiovascular Magnetic Resonance Imaging (MRI), Echocardiography, Tonometry, Genetic Testing (Blood), Hand-Grip Strength Measurement
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cardiovascular Magnetic Resonance Imaging (MRI)Other
Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images.
EchocardiographyOther
To measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure.
TonometryOther
Tonometry is a noninvasive method to obtain arterial pressure waveform
Genetic Testing (Blood)Other
The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease.
Hand-Grip Strength MeasurementOther
We will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on.
Body Fat Mass AnalysisOther
Body composition will be analysed by a body composition analyser machine onto which you will have to stand on.
| Study group | Role | What they receive |
|---|---|---|
| Control | Healthy Volunteers will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Hand-Grip Strength Measurement Body Fat Mass Analysis Receives: Other: Cardiovascular Magnetic Resonance Imaging (MRI); Other: Echocardiography; Other: Tonometry; Other: Genetic Testing (Blood); Other: Hand-Grip Strength Measurement; Other: Body Fat Mass Analysis | |
| Ageing | Ageing cohort will undergo the following studying procedures:
Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Body Fat Mass Analysis Receives: Other: Cardiovascular Magnetic Resonance Imaging (MRI); Other: Echocardiography; Other: Tonometry; Other: Genetic Testing (Blood); Other: Body Fat Mass Analysis |
What is being measured
The primary outcome is the main question the study is designed to answer.
First occurrence of cardiovascular event
Measured: 1 Year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jun 2016 (estimated)
- Study startJul 2014
- Primary completionApr 2017 (estimated)
- Study completionApr 2017 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for AgeingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 800 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Heart Centre Singapore
- Sponsor type
- University, hospital or other
- Collaborators
- National University of Singapore
- Responsible party
- Sponsor
- Investigators
- Su-Mei Angela Koh, MBBS, Principal investigator, National Heart Centre Singapore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02791139
- Sponsor's protocol ID
- 2014/628/C
- Acronym
- CardiacAging
- Status last verified
- May 2016
- First submitted
- 31 May 2016
- Last updated
- 16 Jun 2016
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- No
Publications
Tan GHM, Yang E, Tan BZY, Naghshbandi H, Loh J, Zhong X, Liu J, Lim DJ, Gao F, Kovalik JP, Tan RS, Yeo SY, Koh AS. A machine learning approach to conglomerate multi-domain features of cardiac aging. Eur Heart J Digit Health. 2026 Aug 17;7(7):ztag136. doi: 10.1093/ehjdh/ztag136. eCollection 2026 Aug.
PubMed 42644157Wong JJ, Zhang H, Leng S, Gao F, Zhao X, Tan K, Tan RS, Zhong L, Koh AS. Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk. Eur Heart J Imaging Methods Pract. 2025 Jun 4;3(1):qyaf075. doi: 10.1093/ehjimp/qyaf075. eCollection 2025 Jan.
PubMed 40584917Wang LYT, Lim WS, Tan RS, Teo LLY, Tan SY, Ooi CH, Ong ACW, Kovalik JP, Goh J, Gao F, Koh AS. Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging. Sci Rep. 2025 May 5;15(1):15679. doi: 10.1038/s41598-025-00657-4.
PubMed 40325063Chng ACC, Tan HC, Teo LLY, Tan RS, Ewe SH, Leng S, Zhao XD, Zhong L, Koh WP, Kovalik JP, Gao F, Koh AS. Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging. Geroscience. 2025 Apr;47(2):1911-1921. doi: 10.1007/s11357-024-01387-7. Epub 2024 Oct 14.
PubMed 39397221Zhang H, Leng S, Gao F, Kovalik JP, Tan RS, Wee HN, Chua KV, Ching J, Zhao X, Allen J, Wu Q, Leiner T, Zhong L, Koh AS. Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging. Geroscience. 2024 Dec;46(6):5459-5471. doi: 10.1007/s11357-024-01127-x. Epub 2024 Mar 22.
PubMed 38514519Tan YH, Lim JP, Lim WS, Gao F, Teo LLY, Ewe SH, Keng BMH, Tan RS, Koh WP, Koh AS. Obesity in Older Adults and Associations with Cardiovascular Structure and Function. Obes Facts. 2022;15(3):336-343. doi: 10.1159/000521729. Epub 2022 Mar 4.
PubMed 35249039Kovalik JP, Zhao X, Gao F, Leng S, Chow V, Chew H, Teo LLY, Tan RS, Ewe SH, Tan HC, Wee HN, Lee LS, Ching J, Keng BMH, Koh WP, Zhong L, Koh AS. Amino acid differences between diabetic older adults and non-diabetic older adults and their associations with cardiovascular function. J Mol Cell Cardiol. 2021 Sep;158:63-71. doi: 10.1016/j.yjmcc.2021.05.009. Epub 2021 May 24.
PubMed 34033835Koh AS, Velmurugan B, Gao F, Tan RS, Wong JI, Teo LLY, Keng BMH, Chua SJM, Yuan JM, Koh WP, Cheung C. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017 Nov 28;17(1):275. doi: 10.1186/s12877-017-0668-0.
PubMed 29179674
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
- ClinicalTrials.gov ID
- NCT02791139
- Acronym / sponsor ID
- CardiacAging / 2014/628/C
- Conditions
- Ageing
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 800 participants (estimated)
- Lead sponsor
- National Heart Centre SingaporeUniversity, hospital or other
- Collaborators
- National University of Singapore
- Study start
- Jul 2014
- Primary completion
- Apr 2017 (estimated)
- Study completion
- Apr 2017 (estimated)
- First posted
- 6 Jun 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.
Detailed description
This proposal will investigate how midlife factors in diet and lifestyle affect various aspects of cardiac structure and function related to ageing. The investigators plan to conduct the study among a sub-cohort of 600 participants from the Singapore Chinese Health Study. Comprehensive information on diet and lifestyle factors had been collected at recruitment and updated in two subsequent follow-up interviews. Candidate nutrition-related blood biomarkers such as vitamins D, homocysteine, fatty acids (short, medium and long-chain) and lipids (LDL, HDL, triglycerides) will be analyzed from samples obtained between 1999 and 2004. The investigators will study effects of smoking, alcohol consumption, sleep duration, physical activity and diet on cardiac ageing. The investigators will study overall dietary pattern, intake of specific items such as fatty acids, soy food, coffee and tea beverages, from validated food frequency questionnaires (FFQ), and nutrients from questionnaire information from this cohort previously obtained.
These nutrient and lifestyle factors will be studied individually, and for their joint or interactive effects on cardiac ageing measurements. Quantitative cardiac ageing-related outcome parameters describing cardiac mass, systolic and diastolic function, and vessel distensibility will be examined by cardiac magnetic resonance imaging. Maximum oxygen uptake (VO2 max) will be calculated based on age, gender, waist circumference, resting heart rate, and exercise habits. Body composition will be analysed by a body composition analyser machine onto which subjects stand on.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control | – | Other: Cardiovascular Magnetic Resonance Imaging (MRI), Other: Echocardiography, Other: Tonometry, Other: Genetic Testing (Blood), Other: Hand-Grip Strength Measurement, Other: Body Fat Mass AnalysisHealthy Volunteers will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Hand-Grip Strength Measurement Body Fat Mass Analysis |
| Ageing | – | Other: Cardiovascular Magnetic Resonance Imaging (MRI), Other: Echocardiography, Other: Tonometry, Other: Genetic Testing (Blood), Other: Body Fat Mass AnalysisAgeing cohort will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Body Fat Mass Analysis |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- 600 ageing participants randomly chosen from a current pool of about 5290 surviving cohort participants in the Singapore Chinese Health Study will be recruited. 200 Healthy Volunteers control group
Key inclusion criteria (4 listed)
- Who were younger than 60 years at recruitment
- Had been interviewed at baseline and at the two follow-up interviews
- Had provided biospecimens for research previously before the age of 65 years (2000-2004)
- Who will be 65 years or older by 2013
Key exclusion criteria (6 listed)
- Any known history of heart disease or stroke
- Anticipated life expectancy < 1 year
- Unable to provide written informed consent to participate in the study
- Patients with cancer
- Patients with chronic renal disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cardiovascular Magnetic Resonance Imaging (MRI)Cardiovascular MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create heart images. | Other | Ageing, Control |
| EchocardiographyTo measure heart chamber size, heart function, blood vessel size and blood vessel function. These measurements will help us understand the type and severity of heart failure. | Other | Ageing, Control |
| TonometryTonometry is a noninvasive method to obtain arterial pressure waveform | Other | Ageing, Control |
| Genetic Testing (Blood)The blood will be stored for genetic tests and development of cell lines to study genetic risks for aging related diseases and cardiovascular disease. | Other | Ageing, Control |
| Hand-Grip Strength MeasurementWe will measure your hand grip strength using a standard hand dynamometer which is a portable meter that you will use your hands to press on. | Other | Control |
| Body Fat Mass AnalysisBody composition will be analysed by a body composition analyser machine onto which you will have to stand on. | Other | Ageing, Control |
Primary outcome
First occurrence of cardiovascular event
Time frame: 1 Year
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2016.
- Derived from this study: PubMed 42644157Tan GHM, Yang E, Tan BZY, Naghshbandi H, Loh J, Zhong X, Liu J, Lim DJ, Gao F, Kovalik JP, Tan RS, Yeo SY, Koh AS. A machine learning approach to conglomerate multi-domain features of cardiac aging. Eur Heart J Digit Health. 2026 Aug 17;7(7):ztag136. doi: 10.1093/ehjdh/ztag136. eCollection 2026 Aug.
- Derived from this study: PubMed 40584917Wong JJ, Zhang H, Leng S, Gao F, Zhao X, Tan K, Tan RS, Zhong L, Koh AS. Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk. Eur Heart J Imaging Methods Pract. 2025 Jun 4;3(1):qyaf075. doi: 10.1093/ehjimp/qyaf075. eCollection 2025 Jan.
- Derived from this study: PubMed 40325063Wang LYT, Lim WS, Tan RS, Teo LLY, Tan SY, Ooi CH, Ong ACW, Kovalik JP, Goh J, Gao F, Koh AS. Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging. Sci Rep. 2025 May 5;15(1):15679. doi: 10.1038/s41598-025-00657-4.
- Derived from this study: PubMed 39397221Chng ACC, Tan HC, Teo LLY, Tan RS, Ewe SH, Leng S, Zhao XD, Zhong L, Koh WP, Kovalik JP, Gao F, Koh AS. Associations between glycated haemoglobin and multi-modal imaging markers of early cardiac aging. Geroscience. 2025 Apr;47(2):1911-1921. doi: 10.1007/s11357-024-01387-7. Epub 2024 Oct 14.
- Derived from this study: PubMed 38514519Zhang H, Leng S, Gao F, Kovalik JP, Tan RS, Wee HN, Chua KV, Ching J, Zhao X, Allen J, Wu Q, Leiner T, Zhong L, Koh AS. Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging. Geroscience. 2024 Dec;46(6):5459-5471. doi: 10.1007/s11357-024-01127-x. Epub 2024 Mar 22.
- Derived from this study: PubMed 35249039Tan YH, Lim JP, Lim WS, Gao F, Teo LLY, Ewe SH, Keng BMH, Tan RS, Koh WP, Koh AS. Obesity in Older Adults and Associations with Cardiovascular Structure and Function. Obes Facts. 2022;15(3):336-343. doi: 10.1159/000521729. Epub 2022 Mar 4.
- Derived from this study: PubMed 34033835Kovalik JP, Zhao X, Gao F, Leng S, Chow V, Chew H, Teo LLY, Tan RS, Ewe SH, Tan HC, Wee HN, Lee LS, Ching J, Keng BMH, Koh WP, Zhong L, Koh AS. Amino acid differences between diabetic older adults and non-diabetic older adults and their associations with cardiovascular function. J Mol Cell Cardiol. 2021 Sep;158:63-71. doi: 10.1016/j.yjmcc.2021.05.009. Epub 2021 May 24.
- Derived from this study: PubMed 29179674Koh AS, Velmurugan B, Gao F, Tan RS, Wong JI, Teo LLY, Keng BMH, Chua SJM, Yuan JM, Koh WP, Cheung C. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017 Nov 28;17(1):275. doi: 10.1186/s12877-017-0668-0.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Su-Mei Angela Koh, MBBS contact
Su-Mei Angela Koh, MBBS principal investigator
National Heart Centre Singapore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ageing, run by National Heart Centre Singapore at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 16 Jun 2016. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Su-Mei Angela Koh, MBBS (angela.koh.s.m@singhealth.com.sg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
First occurrence of cardiovascular event (time frame: 1 Year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02791139, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2016.