Clinical trials: Cardiac Ageing
Copd, Aging
Evaluation of Cardiac Variability After a Vitamine D Protocol and Whole Body Vibration
Evaluation of heart rate variability in time and frequency domains, in Chronic Obstructive Pulmonary Disease (COPD) after 03 months of vitamine D supplementation and whole body vibration (WBV) training
- Trial name
- NCT03679325
- Testing
- vitamine D, whole body vibration (WBV)
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Maíra F Pessoa
Osteoarthritis, Knee, Myocardial Infarction, Acute
Algarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR)
This study aims to develop, implement, and determines the effectiveness of a personalized medicine approach to each individual's phenotype, based on an innovative physical exercise program to promote the treatment of pain and…
- Conditions
- Osteoarthritis, Knee, Myocardial Infarction, Acute, Hypertension, Dyslipidemias
- Trial name
- A3-COR (NCT05999110)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv
Menopause, Depression
Depression, Aging, Stress and Heart Health Study
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women.
- Conditions
- Menopause, Depression, Heart Disease in Women, Stress
- Trial name
- DASHH (NCT05570721)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Acute Kidney Injury Cardiac Surgery, Postoperative Complications
Vascular Aging and Acute Kidney Injury After Cardiac Surgery
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
- Conditions
- Acute Kidney Injury Cardiac Surgery, Postoperative Complications, Vascular Aging
- Trial name
- NCT07727772
- Testing
- Multidimensional Vascular Aging Assessment
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cardiac Ageing, Physical Activity
The Cardio-Sarcopenia Study
The use of surrogate markers such as body mass index (BMI) as a target outcome of physical activity may not be appropriate in older adults who are at risk of muscle sarcopenia.
- Conditions
- Cardiac Ageing, Physical Activity, Older Adults, Sarcopenia
- Trial name
- NCT05203406
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Ventricular Function
The Effect of Exercise and Alagebrium on the Diastolic Function of the Heart
The purpose of this study is to determine whether an investigational drug (Alagebrium (generic: ALT-711), a type of medication referred to as an advanced glycaton end-product clever) can be combined with exercise training to…
- Trial name
- AGE (NCT01014572)
- Testing
- Aerobic Exercise Training, Alagebrium (generic: ALT-711), Tai Chi and/or Yoga Training
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Healthy, Vascular Stiffness
Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC)
The conduit arteries exhibit a viscoelastic behavior. Visco-elasticity is partially regulated by endothelium and contributes to the optimization of the heart-vessel coupling.
- Conditions
- Healthy, Vascular Stiffness, Aging
- Trial name
- BRADYVASC (NCT02584439)
- Testing
- ivabradine
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Cardiovascular Diseases, Heart Diseases
Epidemiology of Depression and Heart Failure in Aging
To understand how depression leads to congestive heart failure (CHF) in older adults.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Heart Failure, Congestive
- Trial name
- NCT00241761
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aging, Heart Failure
The COmPLETE Study
The project is designed as a large scale, cross-sectional study. This research seeks to identify physical fitness and cardiovascular parameters that best resemble underlying cardiovascular risk with age.
- Trial name
- COmPLETE (NCT03986892)
- Testing
- Physical Activity
- Where
- Switzerland
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Arno Schmidt-Trucksäss
Heart Failure With Normal Ejection Fraction
The Heart Failure With Preserved Ejection Fraction (HFpEF) Pathophysiology Study.
The study addresses the hypothesis that a gradual build-up in arterial resistance and microvascular endothelial dysfunction due to common comorbidities such as hypertension and diabetes mellitus, on top of age related vascular…
- Trial name
- IDENTIFY-HF (NCT03186833)
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Cardiovascular Diseases, Coronary Artery Disease
Senescence in Myocardial Infarction
The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Aging, Atherosclerosis
- Trial name
- SMI (NCT07693712)
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Acute Myocardial Infarction
SILVER-AMI: Outcomes in Older Persons With Heart Attacks
SILVER-AMI is a research study of older persons who are admitted to the hospital with a heart attack. Patients will be interviewed in the hospital and again 6 months later.
- Trial name
- SILVER-AMI (NCT01755052)
- Where
- 81 sites in United States
- Volunteers
- 3,042 people
- Sponsor
- Yale University
HIV Infections, Coronary Disease
HIV-HEART Aging Study
The HIV/HEART Aging study (HIVH) is an ongoing, prospective, multicentre trial that was conducted to assess the incidence, the prevalence and the clinical course of cardiovascular diseases (CVD) in HIV-infected patients.
- Conditions
- HIV Infections, Coronary Disease, Myocardial Infarction, HIV Encephalopathy
- Trial name
- HIVH (NCT04330287)
- Where
- 5 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Essen
Heart Failure, Aging
DNA Methylation Trajectories in Aging
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in…
- Trial name
- EPI-GERAS (NCT06582992)
- Testing
- RRBS
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Heart Disease (Coronary Artery Disease, Ischemic Heart Disease, Hypertensive Heart Disease), Uncontrolled Diabetes (HBA1c ≥ 10)
Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline
Conduct a pilot randomized control to assess the preliminary efficacy of IPROACTIF, an occupational therapist-delivered primary care intervention for aging and chronic disease management.
- Trial name
- NCT04682977
- Testing
- IPROACTIF (Integrated PRimary Care and Occupational Therapy for Aging and Chronic Disease Treatment to preserve Independence and Functioning), Usual primary care services
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Illinois at Chicago
Cardiovascular Disease, Obesity
Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population
The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed.
- Conditions
- Cardiovascular Disease, Obesity, Atherosclerosis, Heart; Disease, Activity
- Trial name
- ExAMIN AGE (NCT02796976)
- Testing
- Training or control condition
- Where
- Switzerland
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Basel
Amyloid Cardiomyopathy, Transthyretin-Related
Screening for Cardiac Amyloidosis With Nuclear Imaging for Minority Populations
In this study, the investigators recruited a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood…
- Trial name
- SCAN-MP (NCT03812172)
- Testing
- 99mTc-PYP or 99m Tc-HDP
- Where
- 4 sites in United States
- Volunteers
- 646 people
- Sponsor
- Mathew S. Maurer, MD
Coronary Disease, Cardiovascular Diseases
Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect…
- Trial name
- CHAS (NCT00626379)
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Northwestern University