Clinical trials: Calcifications Vascular
Coronary Artery Disease
BM Shockwave Devices Clinical Study in Coronary Calcified Lesions
This clinical trial is a prospective, multicenter, single-arm, target-value study to verify the safety and efficacy of BM coronary shockwave devices for the treatment of coronary calcification lesions.
- Trial name
- NCT07010094
- Testing
- BM shockwave devices
- Where
- China
- Volunteers
- 198 people
- Sponsor
- BrosMed Medical Co., Ltd
Hypertension, Atherosclerosis
Renal Artery Calcium and Hypertension
CT of the abdomen is a very common examination performed for various indications.One of the common findings is vascular calcifications including calcifications of the renal arteries.Calcifications in the carotid arteries and…
- Trial name
- NCT00388869
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Coronary Stenosis, Calcific Coronary Arteriosclerosis
CT in Calcified Coronary Arteries With Photon Counting Detector
Coronary CT angiography is challenging in patients with more than mildly calcified coronary vessels, because of calcium artefacts that prevents evaluation of the lumen.
- Trial name
- CCT-PCD-1 (NCT05551351)
- Testing
- Cardiac CT with photon counting detector
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Region Örebro County
Coronary Artery Calcification, Left Main Coronary Artery Disease
Intravascular Balloon Lithotripsy in Left Main Stem Percutaneous Coronary Intervention
The IVL Left Main study is a prospective non-randomised pilot study to investigate the mechanical and procedural outcomes and safety of distal left main stenting with coronary lithotripsy in addition to standard techniques in…
- Trial name
- NCT04319666
- Testing
- Left main stenting with intravascular lithotripsy
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
Shockwave IVL + DES
The objective of this clinical investigation is to evaluate, in a controlled setting, the 12 months safety and efficacy of the combination of Shockwave Intravascular Lithotripsy and a polymer coated Drug Eluting Stent device, for…
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Calcifications Vascular
- Trial name
- Shockwave DES (NCT05291247)
- Testing
- Peripheral lithotripsy system (Shockwave Medical)
- Where
- 6 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Marc Bosiers, MD
Calcifications, Vascular
Ultrasound Assessment of Arterial Medial Calcification in Endurance Athletes: A Prevalence Study
Medial arterial calcification (MAC) is an under-recognized vascular condition that remains poorly characterized from an epidemiological perspective.
- Trial name
- EMASE (NCT07419126)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hemodialysis
Use of ETElcalcetidefor pReserving vitamiN K-dependent proteIn activiTY ITAlian Study
The goal of this Prospective Observational Study of comparative effectiveness is to provide real world evidence of the effect of Etelcalcetide in increasing actives form VKDPs levels such as BGP and MGP at 3, 9 and 18 months from…
- Trial name
- ETERNITY-ITA (NCT06352957)
- Volunteers
- 160 people
- Sponsor
- Istituto di Fisiologia Clinica CNR
Coronary Artery Disease
The Effects of Vitamin K2 Supplementation on the Progression of Coronary Artery Calcification
Both Coronary Artery Calcification (CAC)and its annual progression are a strong predictors of cardiovascular events. The development of arterial calcification results from imbalance between calcification promoting and inhibiting…
- Trial name
- VitaK-CAC (NCT01002157)
- Testing
- Menaquinone-7 (Vitamin K2)
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
Feasibility of Orbital Atherectomy System in Calcified Bifurcation Lesion
ORBID-OA is a single-center, observational study in 30 patients with stable coronary artery disease. The aim of the study is to analyze the outcomes of main vessel stenting on side branch in calcified bifurcation lesion and…
- Trial name
- ORBID-OA (NCT03058510)
- Testing
- Frequency domain optical coherence tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atrial Fibrillation or Pulmonary Embolism, Need of Long Term Oral Anticoagulation Therapy (OAT)
Rivaroxaban Compared to Vitamin K Antagonist Upon Development of Cardiovascular Calcification
The following trial hypothesis will be proved: In patients with atrial fibrillation and/ or pulmonary embolism standard anticoagulant treatment with coumadin/phenprocoumon is associated with accelerated coronary or valvular…
- Conditions
- Atrial Fibrillation or Pulmonary Embolism, Need of Long Term Oral Anticoagulation Therapy (OAT), Existent Coronary or Valvular Calcification, or Both and Agatston Score > 50 in at Least One Location
- Trial name
- NCT02066662
- Testing
- Rivaroxaban or Marcumar
- Where
- 3 sites in Germany
- Volunteers
- 192 people
- Sponsor
- RWTH Aachen University
Cardiovascular Diseases
ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score on Computed Tomography
The primary objective of the ASA-3C trial is to evaluate the role of aspirin and high-intensity statin therapy, respectively, in individuals with severe coronary calcification (coronary calcium score ≥300) to prevent…
- Trial name
- ASA-3C (NCT06676280)
- Testing
- Aspirin, High-intensity statin, Guideline-directed statin therapy
- Where
- 32 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Jung-min Ahn
Diabetic Vascular Diseases, Arteriosclerosis Obliterans
Arterial Calcification in the Diabetes
The blood concentration of the protein RANKL could be predictive of the calcification of the leg arteries, which is a major complication occurring during diabetes.
- Conditions
- Diabetic Vascular Diseases, Arteriosclerosis Obliterans, Monckeberg Medial Calcific Sclerosis
- Trial name
- DIACART (NCT02431234)
- Testing
- serum RANKL
- Where
- France
- Volunteers
- 169 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Diseases, Coronary Artery Calcification
Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients
Vessel calcification is a recognised cardiovascular morbidity risk factor in patients with chronic kidney disease (CKD). Recent reports indicate a significant role of Matrix Gla-protein (MGP) in decreasing calcification…
- Trial name
- CACSK2 (NCT01101698)
- Testing
- Vitamin K2+10μg cholecalciferol, Vitamin D
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Peripheral Arterial Disease, Calcifications Vascular
SOLUTION Trial in China
This is a prospective, multicenter, single arm study, to support the safety and effectiveness assessment of the Shockwave Medical Peripheral IVL System applied to Chinese patients
- Trial name
- NCT05434676
- Testing
- Shockwave Medical Peripheral Intravascular Lithotripsy (IVL) System M5 & S4
- Where
- 5 sites in China
- Volunteers
- 20 people
- Sponsor
- Genesis Medtech Corporation
Generalized Arterial Calcification of Infancy, Autosomal Recessive Hypophosphatemic Rickets Type2
Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)
Background: Generalized Arterial Calcification of Infancy (GACI) is a very rare disorder. It can be fatal before birth or by age 6 months. Anumber of people with GACI survive into adulthood.
- Trial name
- NCT03478839
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Chronic Limb Threatening Ischemia, Chronic Limb-Threatening Ischemia
REsorbable SCaffolds With everolimUs-Elution for the Treatment of Infrapopliteal Artery Disease in Patients With Chronic Limb-threatening Ischemia
RESCUE is a Europe-wide study that will follow 400 people with critical limb-threatening ischemia (CLTI). It aims to see how well Esprit BTK™ Everolimus Eluting Resorbable Scaffolds work in real-life medical settings.
- Trial name
- RESCUE (NCT07270575)
- Testing
- Esprit BTK™ Everolimus Eluting Resorbable Scaffold from Abbott
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Cardiovascular and Interventional Radiological Society of Europe
Femoropopliteal Artery Occlusion
Outcome of Endovascular Therapies in Chronic Femoropopliteal Occlusive Disease With Severe Calcification
This study is a prospective, multicenter, real world, observational study, which aims at evaluating the safety, efficacy and economic cost of endovascular treatments for endovascular therapies in chronic femoropopliteal occlusive…
- Trial name
- NCT04716361
- Where
- China
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Coronary Artery Disease
Study to Evaluate the Association of Testosterone Levels With Coronary Artery Calcification
Coronary artery calcification (CAC) is a pandemic condition in elderly patients with coronary artery disease (CAD) and associated with worse prognosis.
- Trial name
- NCT02310659
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang University
Peripheral Arterial Disease
The Jetstream G3™ Calcium Study
To investigate the treatment effects with the Jetstream G3 System in moderate to severely calcified peripheral artery disease in the common femoral, superficial femoral or popliteal arteries using intravascular ultrasound (IVUS).
- Trial name
- NCT01273623
- Testing
- Jetstream Atherectomy System
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Boston Scientific Corporation
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry