Clinical trials: Bronchiectasis Adult, active
Bronchiectasis Adult
The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping
Bronchiectasis is a complex heterogeneous disorder. Treatment is challenging and many recent randomized controlled trials have been negative.
- Trial name
- BRIDGE (NCT03791086)
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Dundee
Bronchiectasis Adult
A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong
Bronchiectasis is associated with repeated exacerbations which occurs at rates of 1.5-6.5 per patients per year, and are associated with an increased risk of admission and readmission to hospital, and high health care costs.
- Trial name
- NCT04538859
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Cystic Fibrosis (CF), Bronchiectasis Adult
Novel Sensors and Artificial Intelligence for Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis and Bronchiectasis
The goal of this observational study is to learn about new sensors that measure changes in the body that happen during a chest infection, such as breathing rate and heart rate.
- Trial name
- NOVEL (NCT07289100)
- Testing
- Non-Interventional Study
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Bronchiectasis with Acute Exacerbation
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and…
- Trial name
- NCT06726356
- Testing
- Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
Exploring How Viral Infections Affect People With Chronic Lung Disease
Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger.
- Conditions
- Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation, COPD (Chronic Obstructive Pulmonary Disease), Respiratory Infection Virus
- Trial name
- PRIVILEGE (NCT06625944)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Imperial College London
Bronchiectasis Adult
Long-term Impact of Inhaled Tobramycin for Pseudomonas Aeruginosa Eradication in Bronchiectasis (ERASE II)
The ERASE II study is a prospective follow-up study designed to assess the long-term impact of successful eradication of Pseudomonas aeruginosa (PA) in patients with bronchiectasis.
- Trial name
- NCT06760273
- Testing
- No Intervention: Observational Cohort
- Where
- 58 sites in China
- Volunteers
- 364 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bronchiectasis Adult
REGEND001 Autologous Basal Layer Stem Cell Transplantation for Bronchiectasis: A Translational Application Study
This clinical trial aims to evaluate the safety and efficacy of REGEND001, an autologous basal layer stem cell transplantation therapy, in patients with chronic structural lung disease (bronchiectasis).
- Trial name
- NCT06987214
- Testing
- REGEND001 Autologous Basal Layer Stem Cell Suspension
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Bronchiectasis Adult
Combined Effects of Resonant Breathing and Qigong Exercises in Bronchiectasis
Bronchiectasis is a chronic lung disease characterized by permanent dilation of the bronchi, leading to persistent cough, mucus overproduction, dyspnea and frequent respiratory infections.
- Trial name
- NCT07725991
- Testing
- Resonant breathing and Qigong Exercise., Resonant breathing exercise
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Bronchiectasis Adult
The C-BRIDGE Study: China Bronchiectasis Research Involving Databases, Genomics, and Endotyping
Bronchiectasis is a heterogeneous airway disease with diverse causes, making precise diagnosis, prognosis, and treatment response prediction challenging.
- Trial name
- NCT06900062
- Where
- 9 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Idiopathic Bronchiectasis
Primary Ciliary Dyskinesia in Adult Bronchiectasis
The purpose of this study is to help determine how often primary ciliary dyskinesia (PCD) is present but undiagnosed in adults with bronchiectasis.
- Trial name
- NCT07566611
- Testing
- Nasal Nitric Oxide Measurement, Nasopharyngeal (Nasal) Samples
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Bronchiectasis Adult
Respiratory Physiotherapy for Patients With Bronchiectasis
Study design: observational, retrospective Population: 270 patients diagnosed with bronchiectasis (BX) treated at the Respiratory Physiotherapy Unit of the Rehabilitation Service of the A Coruña and Cee Health Area.
- Trial name
- PhysioBX (NCT07733323)
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- Yolanda Sanesteban Hermida
Non-cystic Fibrosis Bronchiectasis
Dose Range Finding, Efficacy, and Safety Study of Nebulized CSL787 in Adults With Non-cystic Fibrosis Bronchiectasis (NCFB)
This study is a proof-of-concept phase 2b, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose selection study designed to explore the efficacy, safety, and tolerability of 2 active treatment regimens…
- Trial name
- NCT07048262
- Testing
- CSL787, Nebulizer
- Where
- 13 sites in Australia, Japan
- Volunteers
- 180 people
- Sponsor
- CSL Behring
Non-cystic Fibrosis Bronchiectasis
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Adult Study Participants With Non-Cystic Fibrosis Bronchiectasis
The purpose of the study is to investigate the efficacy of galvokimig versus placebo on the time to the first pulmonary exacerbation in study participants with non-cystic fibrosis bronchiectasis (NCFB)
- Trial name
- ATMOS (NCT07720375)
- Testing
- Galvokimig
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- UCB Biopharma SRL
Bronchiectasis Adult
Study on Doses of Inhaled ALX1 in Adults With Bronchiectasis
This study will evaluate the safety and effects of ALX1, an inhaled investigational treatment, in adults with bronchiectasis. Participants will receive either ALX1 or a placebo (a treatment with no active medicine) for 14 days.
- Trial name
- NCT07731919
- Testing
- ALX1
- Volunteers
- 28 people
- Sponsor
- Vast Therapeutics
Bronchiectasis
Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis
Chronic airways infection with Pseudomonas aeruginosa (PA) is associated with increased frequency of exacerbations, deterioration in quality of life and increased mortality in adult patients with bronchiectasis.
- Trial name
- ANTEIPA (NCT06368804)
- Testing
- Antibiotic monotherapy treatment and follow-up, Antibiotic bitherapy treatment and follow-up
- Where
- 18 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Bronchiectasis Adult
Benefits of Inhalation of Hypertonic Saline Solution Prior to Physiotherapy ELTGOL Technique in Bronchiectasis
Bronchiectasis is a chronic bronchial disease in which the usual capacity to remove secretions does not function correctly, causing mucus retention that leads to chronic infection.
- Trial name
- NCT06443658
- Testing
- Hypertonic saline, Isotonic saline, ELTGOL
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Chronic Obstructive Pulmonary Disease, Bronchiectasis
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
Background: Some health conditions make breathing difficult and uncomfortable. When this happens every day, it is called chronic breathlessness.
- Conditions
- Chronic Obstructive Pulmonary Disease, Bronchiectasis, Interstitial Lung Disease, Lung Cancer
- Trial name
- SELF-BREATHE (NCT06326957)
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 246 people
- Sponsor
- King's College Hospital NHS Trust
Bronchiectasis, Bronchiectasis Adult
Compare Oral Itraconazole and Standard Care Versus Standard Care Alone in Patients With Non-cystic Fibrosis Related Bronchiectasis With Chronic Aspergillus Infection in Reducing Bronchiectasis Exacerbations
There is an intricate link between bronchiectasis and fungi. Patients with cystic fibrosis frequently manifest fungal sensitization and fungal colonization with Aspergillus fumigatus.6 Aspergillus species also has a…
- Trial name
- BAIT (NCT06160713)
- Testing
- Itraconazole 65 MG, Standard care
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Bronchiectasis With Acute Exacerbation
Efficacy and Safety of Bronchoscopic Local Amikacin Instillation for Acute Exacerbations of Bronchiectasis in Adults: A Multicenter, Blinded, Randomized Controlled Trial
Bronchiectasis is a chronic respiratory system disease characterized by irreversible structural dilation of the bronchi, persistent cough, and alternating periods of stability and acute exacerbation during the clinical course.
- Trial name
- NCT07813299
- Testing
- Bronchoalveolar Lavage and Local Amikacin Injection, Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 186 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Non-cystic Fibrosis Bronchiectasis, Bronchiectasis Adult
Azithromycin to Modify Bronchiectasis Exacerbation Risk
The Azithromycin to Modify Bronchiectasis Exacerbation Risk (AMBER) trial is a prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial in adults with clinically and radiologically confirmed…
- Conditions
- Non-cystic Fibrosis Bronchiectasis, Bronchiectasis Adult, Bronchiectasis, Bronchiectasis With Acute Exacerbation
- Trial name
- AMBER (NCT07608328)
- Testing
- Standard Bronchiectasis Care, Azithromycin
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Assiut University