Clinical trials: Bronchiectasis Adult
Bronchiectasis, Bronchiectasis Adult
Compare Oral Itraconazole and Standard Care Versus Standard Care Alone in Patients With Non-cystic Fibrosis Related Bronchiectasis With Chronic Aspergillus Infection in Reducing Bronchiectasis Exacerbations
There is an intricate link between bronchiectasis and fungi. Patients with cystic fibrosis frequently manifest fungal sensitization and fungal colonization with Aspergillus fumigatus.6 Aspergillus species also has a…
- Trial name
- BAIT (NCT06160713)
- Testing
- Itraconazole 65 MG, Standard care
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Non-cystic Fibrosis Bronchiectasis, Bronchiectasis Adult
Azithromycin to Modify Bronchiectasis Exacerbation Risk
The Azithromycin to Modify Bronchiectasis Exacerbation Risk (AMBER) trial is a prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial in adults with clinically and radiologically confirmed…
- Conditions
- Non-cystic Fibrosis Bronchiectasis, Bronchiectasis Adult, Bronchiectasis, Bronchiectasis With Acute Exacerbation
- Trial name
- AMBER (NCT07608328)
- Testing
- Standard Bronchiectasis Care, Azithromycin
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Assiut University
COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation
Tele-Pulmonary Rehabilitation For Patients With Chronic Lung Diseases
Pulmonary rehabilitation is a key treatment for lung diseases, but many patients struggle to attend sessions due to travel distances, physical limitations, or logistical barriers.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation, Bronchiectasis Adult, Pulmonary Arterial Hypertension (PAH)
- Trial name
- TELE-PRIME (NCT07666841)
- Testing
- Tele-Rehabilitation
- Where
- 2 sites in Israel
- Volunteers
- 90 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Bronchiectasis Adult
Respiratory Physiotherapy for Patients With Bronchiectasis
Study design: observational, retrospective Population: 270 patients diagnosed with bronchiectasis (BX) treated at the Respiratory Physiotherapy Unit of the Rehabilitation Service of the A Coruña and Cee Health Area.
- Trial name
- PhysioBX (NCT07733323)
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- Yolanda Sanesteban Hermida
Bronchiectasis Adult
REGEND001 Autologous Basal Layer Stem Cell Transplantation for Bronchiectasis: A Translational Application Study
This clinical trial aims to evaluate the safety and efficacy of REGEND001, an autologous basal layer stem cell transplantation therapy, in patients with chronic structural lung disease (bronchiectasis).
- Trial name
- NCT06987214
- Testing
- REGEND001 Autologous Basal Layer Stem Cell Suspension
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Bronchiectasis Adult
Study on Doses of Inhaled ALX1 in Adults With Bronchiectasis
This study will evaluate the safety and effects of ALX1, an inhaled investigational treatment, in adults with bronchiectasis. Participants will receive either ALX1 or a placebo (a treatment with no active medicine) for 14 days.
- Trial name
- NCT07731919
- Testing
- ALX1
- Volunteers
- 28 people
- Sponsor
- Vast Therapeutics
Bronchiectasis Adult
Combined Effects of Resonant Breathing and Qigong Exercises in Bronchiectasis
Bronchiectasis is a chronic lung disease characterized by permanent dilation of the bronchi, leading to persistent cough, mucus overproduction, dyspnea and frequent respiratory infections.
- Trial name
- NCT07725991
- Testing
- Resonant breathing and Qigong Exercise., Resonant breathing exercise
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Bronchiectasis Adult, Bronchiectasis With Pseudomonas Aeruginosa Colonization
First in Human Trial of CTX-187 in Healthy Volunteers and Chronically Infected Patients
The primary objective of this trial is to assess the safety and tolerability of single and multiple ascending intravenously (IV) infused doses of CTX-187 when administered to healthy adult male and female participants and…
- Conditions
- Bronchiectasis Adult, Bronchiectasis With Pseudomonas Aeruginosa Colonization, Bacterial Infections
- Trial name
- NCT07708116
- Testing
- CTX-187
- Where
- Netherlands
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centauri Therapeutics Limited
Bronchiectasis Adult, Healthy Controls Group - Age and Sex-matched
Cardiopulmonary Responses to 6-Minute Stepper Test in Bronchiectasis Versus Healthy Controls
Individuals with bronchiectasis exhibit productive cough and recurrent lung infections as well as reduced exercise capacity, physical activity level, and respiratory and peripheral muscle strength.
- Trial name
- NCT06631261
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Bronchiectasis Adult
Role of BARriers in IgG-Pathogen Interactions at the Mucosal Surface in Human Airways
Context. Non cystic fibrosis bronchiectasis (NCFB) is a group of suppurative chronic airway diseases of multiple causes. Bronchiectasis is characterized by an abnormal, irreversible dilatation of the bronchi, airway obstruction…
- Trial name
- BARRIG (NCT06670937)
- Testing
- Induced sputum, Blood sample
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Bronchiectasis Adult, Yoga
Effects of an Online Yoga Program on Exercise Capacity and Quality of Life in Bronchiectasis Patients
Bronchiectasis is a chronic lung disease characterized by persistent cough, sputum production, shortness of breath, and recurrent infections, which can reduce physical capacity and quality of life.
- Trial name
- YOGA-BR (NCT07540936)
- Testing
- Yoga Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Medipol University Hospital
Bronchiectasis Adult, Pseudomonas Aeruginosa Infection
Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Bronchiectasis
People with bronchiectasis are prone to Pseudomonas aeruginosa (PA) infections, which can become chronic and lead to increased death rates and disease severity.
- Trial name
- ERASE (NCT06093191)
- Testing
- Tobramycin Inhalant Product, Ciprofloxacin 750 MG, Natural saline inhalation
- Where
- 60 sites in China
- Volunteers
- 371 people
- Sponsor
- Jin-Fu Xu
Bronchiectasis Adult
Real Life Evaluation of the LibAirty Airway Clearance System in Adults With Bronchiectasis (RELACS)
The purpose of this study is to collect data to assess the use of the LibAirty™ System for improving bronchiectasis symptoms and healthcare resource utilization when it is used at home.
- Trial name
- NCT07135284
- Testing
- Airway clearance system
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Synchrony-Medical, Ltd
Bronchiectasis Adult
Comparison Between Conventional Respiratory Physiotherapy and the Simeox Device in Patients With Bronchiectasis
Physiotherapy is a key treatment for patients with bronchiectasis. An evaluation of the parameters indicative of respiratory health in patients treated with two different respiratory physiotherapy techniques (conventional versus…
- Trial name
- FISIOBRONCHI (NCT06801327)
- Testing
- Simeox
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bronchiectasis Adult
Value of Inhaled Treatment With Aztreonam Lysine in Bronchiectasis
A randomised controlled trial of the safety, tolerability and effectiveness of Cayston Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis.
- Trial name
- VitalBE (NCT03696290)
- Testing
- Aztreonam lysine
- Where
- 14 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Dundee
Bronchiectasis Adult, Expiratory Muscle Training
Effects of Expiratory Muscle Training Added to Pulmonary Rehabilitation in Patients With Bronchiectasis
This randomized, single-blind, parallel-group controlled trial aims to investigate the effects of expiratory muscle training added to standard pulmonary rehabilitation on respiratory muscle strength, pulmonary function, cough…
- Conditions
- Bronchiectasis Adult, Expiratory Muscle Training, Pulmonary Rehabilitation, Lung Function Tests
- Trial name
- NCT07317531
- Testing
- pulmonary rehabilitation, Expiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Demiroglu Bilim University
Cystic Fibrosis (CF), Bronchiectasis Adult
Novel Sensors and Artificial Intelligence for Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis and Bronchiectasis
The goal of this observational study is to learn about new sensors that measure changes in the body that happen during a chest infection, such as breathing rate and heart rate.
- Trial name
- NOVEL (NCT07289100)
- Testing
- Non-Interventional Study
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Bronchiectasis Adult, Radiomics
Multicenter Cohort Study on Predicting Bronchiectasis Progression, Complications, and Prognosis Using Multi-omics
Bronchiectasis is a heterogeneous condition with diverse etiologies and clinical manifestations. Its progression involves a vicious cycle of airway inflammation, recurrent infection, and structural damage, leading to persistent…
- Trial name
- NCT07263373
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Bronchiectasis Adult
The C-BRIDGE Study: China Bronchiectasis Research Involving Databases, Genomics, and Endotyping
Bronchiectasis is a heterogeneous airway disease with diverse causes, making precise diagnosis, prognosis, and treatment response prediction challenging.
- Trial name
- NCT06900062
- Where
- 9 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Bronchiectasis Adult
Evaluation of the Effect of Yoga Training on Functional Capacity and Quality of Life in Patients With Bronchiectasis
Evaluation of the Effect of Yoga Training on Functional Capacity and Quality of Life in Patients with Bronchiectasis between the ages of 30-55
- Trial name
- NCT04744220
- Testing
- Yoga Training Program (exercises)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital