Clinical trials: Bronchiectasis, active
Bronchiectasis Adult
The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping
Bronchiectasis is a complex heterogeneous disorder. Treatment is challenging and many recent randomized controlled trials have been negative.
- Trial name
- BRIDGE (NCT03791086)
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Dundee
Bronchiectasis Adult
A Prospective Study of Factors Related to Exacerbation and Mortality of Non-cystic Fibrosis Bronchiectasis in Hong Kong
Bronchiectasis is associated with repeated exacerbations which occurs at rates of 1.5-6.5 per patients per year, and are associated with an increased risk of admission and readmission to hospital, and high health care costs.
- Trial name
- NCT04538859
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Cystic Fibrosis (CF), Bronchiectasis Adult
Novel Sensors and Artificial Intelligence for Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis and Bronchiectasis
The goal of this observational study is to learn about new sensors that measure changes in the body that happen during a chest infection, such as breathing rate and heart rate.
- Trial name
- NOVEL (NCT07289100)
- Testing
- Non-Interventional Study
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Chronic Lymphocytic Leukemia
Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk
Chronic Lymphocytic Leukemia (CLL) is the most common adult leukemia in western countries. CLL is most often discovered incidentally when a blood test carried out for another reason highlights an increase of subpopulation of…
- Trial name
- NCT06475469
- Testing
- Blood sampling & Chest CT without injection
- Where
- France
- Volunteers
- 75 people
- Sponsor
- CHU de Reims
Bronchiectasis with Acute Exacerbation
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and…
- Trial name
- NCT06726356
- Testing
- Bronchoalveolar Lavage
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Asthma, COPD (Chronic Obstructive Pulmonary Disease)
T2AIR: Real-World Efficacy and Safety of Biologics Targeting Type 2 Inflammation in Asthma and COPD
This prospective, real-world observational study (T2AIR Study) evaluates the long-term efficacy and safety of six biologics targeting Type 2 inflammation - omalizumab, mepolizumab, benralizumab, dupilumab, tezepelumab, and…
- Trial name
- T2AIR (NCT07823842)
- Testing
- Biologics targeting Type 2 inflammation, Patients with asthma and copd who received standard of care
- Where
- China
- Volunteers
- 538 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
COPD, ILD
SWEEP: Shuttle Walking Test for Exercise Evaluation in Pulmonary Resection
This is a prospective observational study that evaluates whether the Shuttle Walking Test (SWT) can predict postoperative symptoms, particularly dyspnea, in patients with chronic respiratory diseases undergoing lung resection.
- Conditions
- COPD, ILD, Bronchiectasis, Lung Cancer NOS
- Trial name
- SWEEP (NCT07102589)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Cystic Fibrosis, Non-CF Bronchiectasis
Regional Phenotyping of CF and Non-CF Bronchiectasis
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy…
- Trial name
- NCT04793867
- Testing
- Xenon
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bronchiectasis
Development of an Interactive Digital Respiratory Game and Device and Investigation of Its Effectiveness in Children With Bronchiectasis
Our study aims to develop a personalized interactive digital breathing game and device that can be produced in our country and to provide daily airway cleaning treatment at home via mobile phone or computer without the need for a…
- Trial name
- NCT06897761
- Testing
- Interactive Digital Respiratory Game, home-based exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Atlas University
Bronchiectasis, Quality of Life
Evaluation of the Quality of Life of Patients With DBB With the Installation of OPEP
To carry out an assessment of compliance and quality of life in a population (children and adults) with DDB before and after the use of an oscillating PEP.
- Conditions
- Bronchiectasis, Quality of Life, Physiotherapy
- Trial name
- EQOPEP (NCT06820983)
- Testing
- adult questionnary for parents of children aged 8 to 13, Quality of life questionnaire for children aged 8 to 13, Quality of life questionnaire for adolescents aged 14 to 17
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bronchiectasis
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had flare-ups (also called exacerbations).
- Trial name
- NCT06872892
- Testing
- BI 1291583
- Where
- 478 sites in United States, Argentina and 44 more
- Volunteers
- 1,755 people
- Sponsor
- Boehringer Ingelheim
Bronchiectasis, Non-Cystic Fibrosis
Long-Term Safety and Efficacy of Moxifloxacin in Bronchiectasis Patients
Bronchiectasis is a chronic respiratory disease characterized by recurrent infections, inflammation, and progressive lung damage.
- Trial name
- NCT07274020
- Testing
- Intermittent Moxifloxacin + Standard Care, Standard Care (in control arm)
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Assiut University
Bronchiectasis
The Clinical Significance of CT-based Biomarkers in the Classification and Prognosis of Bronchiectasis
As the third major chronic airway disease in China, bronchiectasis has a wide range of patients. However, the involved sites, morphological features and airway obstruction of bronchiectasis are varied, and clinical heterogeneity…
- Trial name
- NCT06346938
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Post-Lung Transplantation Bronchiectasis
Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients
This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.
- Trial name
- NCT04582279
- Testing
- Lung ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acute Exacerbations of Bronchiectasis
A Clinical Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Inhaled H057 in the Treatment of Acute Exacerbations of Bronchiectasis
This is a multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of inhaled H057 in the treatment of acute exacerbations of bronchiectasis.
- Trial name
- NCT06958861
- Testing
- Low-dose H057+standard-of-care, High-dose H057+standard-of-care
- Where
- 19 sites in China
- Volunteers
- 180 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Bronchiectasis, Cystic Fibrosis
Natural History of Bronchiectasis
Bronchiectasis is a chronic inflammatory and muco-obstructive condition that results in abnormal dilation of the airways, decline in lung function, frequent exacerbations, and chronic respiratory tract infections.
- Conditions
- Bronchiectasis, Cystic Fibrosis, Autoimmune Disease, Common Variable Immunodeficiency
- Trial name
- NCT00943514
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bronchiectasis
Effects of Energy Conservation Techniques With Pursed Lip Breathing on Quality of Life in Bronchiectasis
Bronchiectasis is the abnormal dilatation of the bronchi. Due to airway dilatation patient is unable to clear the mucus and risk of infection is increased.
- Trial name
- NCT06995989
- Testing
- energy conservation techniques with pursed lip breathing, pursed lip breathing
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Bronchiectasis, Bronchiectasis With Acute Exacerbation
Comparing Active Cycle of Breathing Techniques (ACBT) and Aerobika in Treating Bronchiectasis in Korea
Title: Comparison of Effectiveness Between Active Cycle of Breathing Techniques (ACBT) and Oscillating Positive Expiratory Pressure (OPEP, Aerobika) Device Assisted Treatment in Patients With Bronchiectasis in Korea: A Randomized…
- Trial name
- NCT07037303
- Testing
- Active Cycle of Breathing Technique (ACBT) and Oscillatory Positive Expiratory Pressure (OPEP) group, Active Cycle of Breathing Technique (ACBT) group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chungbuk National University Hospital
Bronchiectasis, Functional Inspiratory Muscle Training
Functional Inspiratory Training in Bronchiectasis
Bronchiectasis is a chronic respiratory disease clinically characterized by recurrent pulmonary exacerbations, chronic cough, and sputum production, and is associated with an increase in the airway-artery ratio and permanent…
- Trial name
- NCT07188675
- Testing
- Functional Inspiratory Muscle Training (FIMT), Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Elif Kabasakal
Bronchiectasis, Mucus; Plug
Simeox 200 US Study
The purpose of this single arm post-market observational study is to evaluate the short-term effectiveness of the Simeox 200 airway clearance device in improving airway clearance in adult patients aged 18 to 85 with…
- Trial name
- IMPACT (NCT07443124)
- Testing
- Intermittent intrapulmonary deflation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Inogen Inc.