Clinical trials: Bronchiectasis
Bronchiectasis
The Prevalence and Impact of Depression and Anxiety Symptoms in Patients With Non-CF Bronchiectasis
Patients with chronic diseases are at great risk of depression and anxiety.It is known that depression and anxiety are one of the most common comorbidities associated with chronic lung diseases such as asthma and chronic…
- Trial name
- NCT01688180
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease, Non-cystic Fibrosis Bronchiectasis
A Study to Evaluate the Effect of Probiotic Supplement on Quality of Life
This study aims to evaluate the impact of a specific oral probiotic blend on the quality of life of adults with respiratory conditions.
- Trial name
- NCT05523180
- Testing
- Probiotic
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- ResBiotic Nutrition, Inc.
Hay Fever, Asthma
Evaluating the Potential of Large Language Models for Respiratory Disease Consultations
The clinical trial aimes to evaluate multiple large language models in respiratory disease consultations by comparing their performance to that of human doctors across three major medical consultation scenarios.
- Conditions
- Hay Fever, Asthma, Acute Upper Respiratory Infection, Pulmonary Embolism
- Trial name
- EPLLMMRDC (NCT06457269)
- Testing
- Diagnosis by three human doctors, Diagnosis by ChatGPT-3.5 (with search capabilities), Diagnosis by ChatGPT-3.5 (without search capabilities)
- Where
- China
- Volunteers
- 703 people
- Sponsor
- North Sichuan Medical College
Bronchiectasis, Sleep-Disordered Breathing
Sleep Quality in Patients With Non-cystic Fibrosis Bronchiectasis
Non-cystic fibrosis (non-CF) bronchiectasis is a chronic, heterogeneous airway disease characterized by irreversible bronchial dilatation, persistent airway infection, and neutrophilic inflammation that together drive daily…
- Trial name
- NCT07147803
- Testing
- Pittsburgh Sleep Quality Index
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Bronchiectasis
Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?
Oscillatory positive expiratory pressure (OPEP) devices such as Flutter®, Aerobika® or Shaker ® are commonly prescribed in the clinical practice for airway clearance in children with chronic lung diseases including…
- Trial name
- NCT05034900
- Testing
- Chest physiotherapy, Oscillatory Positive Expiratory Pressure (OPEP) device
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Bakircay University
Bronchiectasis Adult
Inhaled A1AT in Adult Stable Bronchiectasis
Aim: to investigate the influence of alpha1-antitrypsin (A1-AT) nebulization on levels of A1-AT in BAL and plasma in patients with stable bronchiectasis. Method: single-blind placebo-controlled randomised clinical trial.
- Trial name
- NCT03383939
- Testing
- Group A, Group B
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Pulmonary Infection, Pulmonary Nodule
COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing fiberoptic bronchoscopy with propofol.
- Conditions
- Pulmonary Infection, Pulmonary Nodule, Endotracheal Tumour, Bronchiectasis
- Trial name
- NCT07063290
- Testing
- the COMBO Endoscopy Oropharyngeal Airway
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zhejiang University
Bronchiectasis
A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis
ACT18018 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 2 study with 3 treatment groups.
- Trial name
- NCT06280391
- Testing
- Itepekimab (SAR440340)
- Where
- 117 sites in United States, Argentina and 18 more
- Volunteers
- 314 people
- Sponsor
- Sanofi
Pediatric Patients With Bronchiectasis
Determination of Physical Fitness Level in Bronchiectasis
The aim of this study is to assess the physical fitness level of children with bronchiectasis. To determine your physical fitness level, we will conduct some game-like tests.
- Trial name
- NCT07121218
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Melis Usul
Bronchiectasis
Effects of Inspiratory Muscle Training in Patients With Bronchiectasis
The purpose of this study is to determine whether inspiratory muscle training could improve and/or prevent the deterioration of inspiratory muscle strength, clinical cardiopulmonary outcome, systemic immunologic responses and…
- Trial name
- NCT00952718
- Testing
- Inspiratory muscle training
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- Chang Gung Memorial Hospital
Bronchiectasis
Clinical Effectiveness Of High Frequency Chest Wall Oscillation (HFCWO) In A Bronchiectasis Population
The primary objective is to compare the patient's baseline QoL prior to HFCWO use against the patient's QoL at various study timepoints over a one-year period of HFCWO use.
- Trial name
- HFCWO (NCT04271969)
- Testing
- SmartVest Airway Clearance System
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Electromed, Inc.
Bronchiectasis
Long-term Prognosis of Children With Bronchiectasis Treated With Low-dose Erythromycin Intervention
According to their compliance, the children were divided into two groups: low dose erythromycin treated group (erythromycin 3-5mg/kg.d orally for 6 months) and non-erythromycin treatment group.
- Trial name
- NCT03966066
- Testing
- erythromycin
- Volunteers
- 70 people
- Sponsor
- Beijing Children's Hospital
Bronchiectasis
Autologous Bronchial Basal Cells Transplantation for Treatment of Bronchiectasis
Bronchiectasis is a result of chronic inflammation compounded by an inability to clear mucoid secretions. Inflammation results in progressive destruction of the normal lung architecture, in particular the elastic fibers of…
- Trial name
- NCT02722642
- Testing
- Bronchial basal cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Regend Therapeutics
Chronic Respiratory Disease, Cystic Fibrosis
The Effect of Proprioceptive Neuromuscular Facilitation (PNF) Technique for Children With Chronic Pulmonary Diseases.
Cystic fibrosis and bronchiectasis are the most seen problems in children with chronic pulmonary diseases. İt is a genetic, chronic system disease that reduces life expectancy, and life quality as well.
- Conditions
- Chronic Respiratory Disease, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT03420209
- Testing
- Group applying PNF technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Bronchiectasis
Effects of Energy Conservation Techniques With Pursed Lip Breathing on Quality of Life in Bronchiectasis
Bronchiectasis is the abnormal dilatation of the bronchi. Due to airway dilatation patient is unable to clear the mucus and risk of infection is increased.
- Trial name
- NCT06995989
- Testing
- energy conservation techniques with pursed lip breathing, pursed lip breathing
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Non-cystic Fibrosis Bronchiectasis
Phase 2a, 28-day Investigational Use Study of ARINA-1 in Non-Cystic Fibrosis Bronchiectasis (NCFBE) With Excess Mucus and Cough
This is a randomized, Phase 2a, double-blind, placebo-controlled study to evaluate the safety and efficacy of ARINA-1 compared to placebo (isotonic saline, 0.9%) in participants with NCFBE.
- Trial name
- NCT05495243
- Testing
- ARINA-1
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- Renovion, Inc.
Bronchiectasis With Acute Exacerbation
Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis…
- Trial name
- NCT06209047
- Testing
- Local instillation of gentamicin and Budesonide, Local instillation of Levofloxacin and Budesonide, Bronchoscopic mechanical secretion suction and lavage
- Where
- Egypt
- Volunteers
- 315 people
- Sponsor
- Assiut University
Bronchiectasis
Expiratory Muscle Training in Bronchiectasis
Reduced exercise tolerance is commonly reported in patients with bronchiectasis. The purpose of this study is to evaluate the effects of expiratory muscle training (EMT) and sham EMT (control) on exercise capacity, respiratory…
- Trial name
- NCT05408455
- Testing
- EMST150 (Expiratory muscle training)
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability
The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01241942
- Testing
- Steen Solution™, Conventional Lung Transplant
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill