Clinical trials: Brain Death
Epilepsy
Cardiac Rhythm Disturbances in Hard-to-treat Epilepsy Patients Using Loop ECG Recorders
Seizure-related cardiac arrhythmias are one of the possible causes of sudden unexpected death in epilepsy (SUDEP). Identification of these patients is challenging because cardiac rhythm disturbances could emerge only during…
- Trial name
- Epi-Loop-Rec (NCT03376087)
- Volunteers
- 193 people
- Sponsor
- National Research Center for Preventive Medicine
Polyvascular Disease, Atherosclerosis
Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis
Аn international, multicenter, non-interventional real-life clinical practice Register studying the Actual therapeutic patient population with Multifocal Atherosclerosis in the Russian Federation and Eurasian countries
- Conditions
- Polyvascular Disease, Atherosclerosis, Atherosclerosis Generalized, Cardiovascular Diseases
- Trial name
- KAMMA (NCT05189847)
- Where
- Russia
- Volunteers
- 3,059 people
- Sponsor
- Eurasian Association of Therapists
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Cerebrovascular Event, Stent Stenosis
Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
APICES trial is an investigator-initiated, multicenter, multicenter, randomized, double-blind, placebo-controlled clinical trial that plans to enroll 396 patients with a 1-year follow-up, including a neurovascular imaging…
- Conditions
- Cerebrovascular Event, Stent Stenosis, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT06308952
- Testing
- Atorvastatin 20mg
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Duan Chuanzhi
Dementia
Animal-Assisted Therapy for People With Dementia
This study is a qualitative anthropological research that explores the effects of Animal-Assisted Therapy (AAT) for people with moderate and severe dementia living in a care facility.
- Trial name
- AATPD (NCT03946696)
- Testing
- Interactions with therapy-animals
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Cardiac Sudden Death, Hypoxia Brain
New Biomarkers of Neurological Outcome After a Sudden Cardiac Death
The aim of the project is to establish the value of circulating microparticles as a new biomarker for neurological prognosis of patients recovered from sudden cardiac death who remain comatose.
- Conditions
- Cardiac Sudden Death, Hypoxia Brain, Cell Membrane Microparticles, Biomarkers
- Trial name
- NCT03962361
- Testing
- Concentration of circulating microparticles.
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
ANCA-associated Primary Necrotizing Vasculitides
Multicenter, Prospective, Randomized, Controlled, Double-blind Trial on the Impact of Rosuvastatin on Subclinical Markers of Atherosclerosis in Patients With Primary Necrotizing Vasculitides
The purpose of this study is to assess whether rosuvastatin could reduce the subclinical markers of atherosclerosis and the incidence of major cardiovascular events in patients with primary necrotizing vasculitides.
- Trial name
- STATVAS (NCT02117453)
- Testing
- Rosuvastatin
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Death, Organ Donor
The Effect of Nebulized Albuterol on Donor Oxygenation
The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation…
- Conditions
- Brain Death, Organ Donor, Pulmonary Edema
- Trial name
- NCT00310401
- Testing
- Albuterol, Saline
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Vanderbilt University Medical Center
Fabry Disease
Arrhythmia Burden, Risk of Sudden Cardiac Death and Stroke in Patients With Fabry Disease
Fabry disease (FD) is a genetic disorder that leads to progressive accumulation of fat or 'sphingolipid' within the tissues, including the heart muscle and conductive tissue.
- Trial name
- RaILRoAD (NCT03305250)
- Testing
- Implantable Loop Recorder
- Where
- 7 sites in Australia, United Kingdom
- Volunteers
- 169 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Mental Illness, Stress
HEAlth Dialogues for Patients With Mental Illness in Primary Care
In the current project, primary health care patients with mental illness such as anxiety, depression, fatigue or sleep disorders will be followed.
- Conditions
- Mental Illness, Stress, Fatigue, Sleep Disorder
- Trial name
- HEAD-MIP (NCT05181254)
- Testing
- health dialogue
- Where
- Sweden
- Volunteers
- 167 people
- Sponsor
- Region Skane
Myocardial Infarction, Cardiac Arrest
Troponin-T for Detection of Perioperative Cardiovascular Events
We will conduct a prospective cohort study evaluating the incidence of and optimal risk estimation model for major perioperative cardiovascular events in consecutive patients undergoing noncardiac surgery at the 'Herlev…
- Trial name
- VISION-pilot (NCT00443989)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Kidney Failure
CINRYZE as a Donor Pre-treatment Strategy in Kidney Recipients of KDPI>60%
Limiting brain death-induced organ injury through a systemic anti- inflammatory medical management should allow for improvement in the quality of transplanted organs, and as a result, clinical improvement in post-transplant…
- Trial name
- NCT02435732
- Testing
- Heparin, CINRYZE
- Volunteers
- 72 people
- Sponsor
- University of Wisconsin, Madison
Death, Myocardial Infarction
A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients
This study evaluates whether achieving 25-hydroxyvitamin D (25[OH] Vit D) levels (>40 ng/mL) among myocardial infarction patients will result in a reduction of cardiovascular-related adverse events.
- Conditions
- Death, Myocardial Infarction, Cerebral Vascular Accident, Heart Failure Hospitalization
- Trial name
- TARGET-D (NCT02996721)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 634 people
- Sponsor
- Intermountain Health Care, Inc.
Brain Death, Liver Disease
Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors
This study's objective is to obtain preliminary data to test the hypotheses that percutaneous liver biopsy in brain death donors is safe and provides reliable histological information.
- Trial name
- PPB (NCT01810640)
- Testing
- Percutaneous Liver Biopsy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Brain Death
Electrical Impedance Tomography Measurements During Apnea Test in Patients With Suspected Brain Death
Apnea testing is the final decisive examination in the strictly regulated process of brain death assessment. There is no standardized method found in the literature for apnea testing except for the inspection of possible…
- Trial name
- NCT04857242
- Testing
- Apnea test, alveolar recruitment
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Cardiology, Critical Care Medicine, Emergency Medical Service
TIMECARD(TaIwan Network of Post-arrest ManagEment for CARDiac Arrest)IIRegistry
This study aims to collect the post-cardiac arrest patients with ICU admission.
- Trial name
- TIMECARDII (NCT06218329)
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Clinical Trial Center
Organ Donation After Circulatory Death
Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death
The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be…
- Trial name
- NeuroDCD (NCT07698262)
- Where
- 11 sites in Canada
- Volunteers
- 102 people
- Sponsor
- University of British Columbia