Clinical trials: Brain Aging
Traumatic Brain Injury, Aging Disorder
Carbon Dioxide Administration and Brain Waste Clearance
The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood.
- Conditions
- Traumatic Brain Injury, Aging Disorder, Magnetic Resonance Imaging (MRI)
- Trial name
- COPETBI (NCT07357090)
- Testing
- Hypercapnia task performed during fMRI
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Andrew Mayer
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Alzheimer Disease, Aging
Vanderbilt Memory and Aging Project
This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults.
- Conditions
- Alzheimer Disease, Aging, Aged, 80 and Over, Biomarkers
- Trial name
- VMAP (NCT05372159)
- Testing
- none, observational study
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
Healthy Aging, Cognitive Benefits
Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences…
- Conditions
- Healthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain Activity
- Trial name
- ExBrain (NCT07727577)
- Testing
- High-Intensity Interval Training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colby-Sawyer College
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Closed-Loop tACS
This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen…
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07722598
- Testing
- Peak Frequency, Phase Lag, Peak Frequency + Phase Lag
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Brain Aging
Synaptic Plasticity Imaging With Diffusion MRI
Diffusion MRI employed in functional imaging has the potential to probe directly brain activation instead of blood changes like the BOLD technique.
- Trial name
- NCT01686516
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Optimal Dosing
This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD).
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07461584
- Testing
- 1-day patterned tACS, 3-day patterned tACS, 5-day patterned tACS
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Aging, Visual Perception
Restructuring the Alpha-Gamma Code in Aging Vision
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on…
- Conditions
- Aging, Visual Perception, Noninvasive Brain Stimulation
- Trial name
- NCT07208318
- Testing
- High definition transcranial electrical current stimulation
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Healthy Aging, Brain Health
Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health
his study investigates whether eating lean beef every day can help support brain health and healthy aging in older adults. As people age, protecting memory and cognitive function becomes increasingly important.
- Conditions
- Healthy Aging, Brain Health, Cardiometabolic Health, Normal Aging
- Trial name
- NCT07623785
- Testing
- Lean Beef, Non-Beef Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Hypoxia, Cerebral Hypoxia
Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional…
- Conditions
- Hypoxia, Cerebral Hypoxia, Brain Diseases, Exercise
- Trial name
- HYPOXAGE (NCT05048680)
- Testing
- Hypoxia and/or Exercise
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
TBI (Traumatic Brain Injury), Stroke
Cognitive Profile of Patients at the Sagol Center for Hyperbaric Medicine and Research
In the investigator's institute there is ongoing treatment of different patients with cognitive deficits using Hyperbaric oxygen therapy (HBOT).
- Conditions
- TBI (Traumatic Brain Injury), Stroke, Fibromyalgia, Aging
- Trial name
- NCT04287283
- Testing
- Hyperbaric Oxygen
- Where
- Israel
- Volunteers
- 2,500 people
- Sponsor
- Assaf-Harofeh Medical Center
Aging, Cognitive Decline
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional product on self-reported cognitive function and health in adults that reside in the…
- Conditions
- Aging, Cognitive Decline, Brain Fog, Cognitive Function
- Trial name
- CLARITY (NCT07060898)
- Testing
- Active Product
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Stroke, Ischemic, Stroke Syndrome
CUHK Brain Health Longitudinal Study
The goal of this study is to develop a large longitudinal cohort of individuals diagnosed with or at high risk for brain diseases (both neurological and psychiatric in nature), in order to identify risk factors that contribute to…
- Conditions
- Stroke, Ischemic, Stroke Syndrome, Stroke, Stroke, Acute
- Trial name
- BHS (NCT03592563)
- Testing
- Neuro-QoL questionnaire
- Where
- 2 sites in Hong Kong
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Mild Cognitive Impairment, Aging
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders.
- Trial name
- NCT03372317
- Testing
- 18F-MK-6240
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yaakov Stern
Cognition, Neurovascular Coupling Mechanism and Cognitive Function
The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults
The goal of this pilot clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular…
- Conditions
- Cognition, Neurovascular Coupling Mechanism and Cognitive Function, Neurovascular Control, Brain Aging
- Trial name
- NCT07209683
- Testing
- transcranial photobiomodulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Brain Aging
Haematococcus Pluvialis Astaxanthin for Brain Aging
We recruit community-dwelling older adults aged 50 and above for a 6-month intervention. Participants are divided into three groups: Placebo Group, Low-Dose Group ( 6 mg/d Haematococcus pluvialis Astaxanthin), High-Dose Group (12…
- Trial name
- NCT07379437
- Testing
- Low-Dose AST, High-Dose AST
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Capital Medical University