Clinical trials: Borrelia Infections
Nervous System Lyme Borreliosis
Study on Early Lyme Neuroborreliosis
The purpose of this study is to determine clinical course and the sequelae of early Lyme neuroborreliosis after treatment with ceftriaxone.
- Trial name
- NCT00910533
- Testing
- ceftriaxone
- Where
- Slovenia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Relapsing Fever, Tick-borne, Jarisch Herxheimer Reaction
Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever
Abstract Background Tick-Borne Relapsing Fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks.
- Trial name
- NCT00237016
- Testing
- doxycycline treatment
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Lyme Borreliosis
Immunogenicity and Safety Study of a Vaccine Against Lyme Borreliosis, in Healthy Adults Aged 18 to 65 Years. Randomized, Controlled, Observer-blind Phase 2 Study.
This is a randomized, observer-blind, placebo controlled, multicenter Phase 2 study conducted in two study phases: a run-in phase and a main study phase.
- Trial name
- NCT03769194
- Testing
- VLA15
- Where
- 9 sites in United States, Belgium and 1 more
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Pfizer
Leishmaniasis, Leptospirosis
Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases
Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments).
- Conditions
- Leishmaniasis, Leptospirosis, Brucellosis, Q Fever
- Trial name
- SEZAM (NCT06859619)
- Testing
- Peripheral venous blood sample
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Montpellier
Lyme Arthritis, Lyme Disease
Symptomatic Management of Lyme Arthritis
Lyme arthritis resolves with appropriate antimicrobial treatment in a majority of patients, but 10-20% of patients develop antibiotic-refractory Lyme arthritis with prolonged arthritis symptoms and treatment courses.
- Conditions
- Lyme Arthritis, Lyme Disease, Arthritis
- Trial name
- NCT04038346
- Testing
- Naproxen, Acetaminophen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Desiree Neville, MD
Post-Lyme Disease Syndrome (PLDS)
Treating Post-Lyme Disease Syndrome With Acetogenins
To access the effectiveness of Acetogenins in treating Post-Lyme Disease Syndrome (PLDS).
- Trial name
- NCT04078841
- Testing
- ReaLife+ (RLP), Inert Brown powder
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Optimal Health Research
Lyme Disease
Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation
IXODES GmbH intends to develop SHB001, an azithromycin dermal formulation in order to prevent Lyme disease at early stages of infection after tick bite.
- Trial name
- IXO-01 (NCT01243008)
- Testing
- Application of SHB001
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lyme Disease
Peripheral Facial Paralysis Sequelae in Lyme Disease Among Children
Neuroborreliosis (NB) is the second most frequent manifestation of Lyme disease. Painful meningoradiculitis is the most common neurologic manifestation in adults while facial nerve palsy (FP) and lymphocytic meningitis is…
- Trial name
- LYMEPED (NCT03981874)
- Testing
- telephonic interview
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Lyme Disease, Lyme Neuroborreliosis
Brain Imaging and Retreatment Study of Persistent Lyme Disease
The purpose of this study is to determine whether patients with persistent memory problems after Lyme disease benefit from an additional longer course of IV antibiotic therapy; to use modern brain imaging technology to determine…
- Trial name
- NCT00037479
- Testing
- ceftriaxone
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Erythema Migrans of Lyme Disease
Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))
The aim of this study is to assess the effect of Saccharomyces boulardii CNCM I-745 on gut microbiota in patients undergoing antibiotic therapy (in the context of erythema migrans (early skin form of Lyme borreliosis)).
- Trial name
- SUBLYME (NCT06451913)
- Testing
- Amoxicillin + Saccharomyces boulardii CNCM I-745, Stool samples, BSFS : Bristol Stool Form Scale
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- Biocodex
Borrelia Burgdorferi Neuroborreliosis
64Cu-DOTATATE-PET for Lyme Neuroborreliosis
The aim of the study is to investigate the applicability and performance of 64Cu-DOTATATE PET/CT/MR for diagnosis in patients with Lyme neuroborreliosis (LNB).
- Trial name
- DOTA-LYME (NCT06392815)
- Testing
- Cu DOTATATE PET
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Facial Palsy, Facial Nerve Diseases
Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy
Acute facial nerve palsy occur in 10-20/100 000 children/year in Sweden. About 20 % of these children will have persistent symptoms with excessive tear secretion, drooling and social problems due to asymmetry in the face.
- Conditions
- Facial Palsy, Facial Nerve Diseases, Borrelia Infection of Central Nervous System, Bell Palsy
- Trial name
- FACE (NCT03781700)
- Testing
- Prednisolone
- Where
- 15 sites in Sweden
- Volunteers
- 343 people
- Sponsor
- Dalarna County Council, Sweden
Chronic Fatigue Syndrome
Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health
Background: Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS) refers to long-lasting and disabling fatigue or malaise, inability to recover after exercise, and physical and emotional discomfort that…
- Trial name
- NCT02669212
- Testing
- Cardiopulmonary Exercise Test (CPET)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Erythema Migrans, Erythema Chronicum Migrans
Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice
Tick borne diseases are increasing in Norway. Lyme borreliosis is the most common infection. Erythema migrans is mainly diagnosed and treated in general practice.
- Conditions
- Erythema Migrans, Erythema Chronicum Migrans, Borreliosis, Lyme Disease
- Trial name
- NorTick_EM (NCT01368341)
- Testing
- Doxycycline, Phenoxymethylpenicillin, Amoxicillin
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Morten Lindbaek
Lyme Disease, Lyme Disease, Chronic
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Lyme Disease
- Trial name
- NCT04148222
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders
Background: Trisomy 8 mosaicism is a genetic disorder that can increase inflammation in the body. Symptoms include fevers; sores or ulcers in the mouth, digestive tract, or genital area; skin rashes; problems in organs or…
- Conditions
- Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease, Mucosal Ulcerations
- Trial name
- NCT07683104
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Facial Paralysis
Microbiologic Findings of Acute Facial Palsy in Children
Objective: Microbiologic etiologies of facial palsy in children were investigated. Study design: Prospective clinical study. Methods: Forty-six children aged 0-16 years with facial palsy comprised the study group.
- Trial name
- NCT01537952
- Volunteers
- 46 people
- Sponsor
- University of Helsinki
Lyme Arthritis
Characteristics of Lyme Arthritis
Lyme disease is due to Borrelia burgdorferi sensu lato and is transmitted by a tick vector of the genus Ixodes. One of the clinical forms of this disease in the disseminated phase is the appearance of arthritis, classically mono…
- Trial name
- ArthLyme (NCT03510507)
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Strasbourg, France
Lyme Disease
A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine
The purpose of this study is to learn about the safety effects of the Lyme disease vaccine (called VLA15), and its ability to protect people from Lyme disease after a 5th dose of the vaccine.
- Trial name
- NCT07500506
- Testing
- VLA15
- Where
- 22 sites in United States, Canada
- Volunteers
- 1,712 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease
Novel Diagnostics for Early Lyme Disease
There are more than 300,000 new cases of Lyme disease every year in the US. Lyme disease is a dangerous bacterial infection transmitted by tick bites and it becomes increasingly severe as the infection progresses.
- Trial name
- NCT03963635
- Testing
- MicroB-plex Lyme Immunoassay
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- MicroB-plex, Inc.