Clinical trials: Bone Remodeling
Osteopenia or Osteoporosis
The Effect of Effervescent Alendronate on Bone Turnover
64 postmenopausal women are randomized to treatment with either effervescent and buffered alendronate or conventional alendronate -both 70mg weekly for 16 weeks to see if bone turnover is suppressed to the same extent as in the…
- Trial name
- NCT05325515
- Testing
- Conventional alendronate, Effervescent and buffered alendronate
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Aarhus University Hospital
Hypoparathyroidism, DiGeorge Syndrome
Effects of PTH Replacement on Bone in Hypoparathyroidism
Hypoparathyroidism is a rare condition associated with a low level of parathyroid hormone (PTH) in the blood. Hypoparathyroidism can be genetic and show up in childhood, or it can occur later in life.
- Trial name
- NCT00395538
- Testing
- PTH 1-34
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Hyperparathyroidism
The Effects of Alendronate After Cure of Primary Hyperparathyroidism
We are investigating whether, after surgical cure of primary hyperparathyroidism, alendronate provides even greater beneficial skeletal effects than parathyroidectomy alone.
- Trial name
- AlenPostPara (NCT00359385)
- Testing
- Alendronate 70mg weekly
- Where
- United States
- Sponsor
- Columbia University
Perimenopausal Bone Loss, Postmenopausal Osteopenia
Prevention of Osteoporosis: Effects of Mini-trampoline Training on the Bone Remodeling
The aim of the project is to study the effects on bone remodeling induced by training carried out with the trampoline in order to evaluate the reduction of the resorption itself and therefore the onset of osteoporosis in women.
- Trial name
- TRAMBONE (NCT04942691)
- Testing
- physical activity
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Palermo
McCune Albright Syndrome, Polyostotic Fibrous Dysplasia
Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome
This study will test the safety and effectiveness of letrozole in treating precocious (early) puberty in girls with McCune-Albright syndrome (MAS).
- Conditions
- McCune Albright Syndrome, Polyostotic Fibrous Dysplasia, Precocious Puberty
- Trial name
- NCT00006174
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Osteoporosis
Effects of Clinical Pilates and Whole Body Vibration Exercises in Postmenopausal Osteoporotic Women
The aim is to compare the effects of clinical pilates and whole body vibration exercises in postmenopausal osteoporotic women on strength, flexibility, balance, bone turnover markers and quality of life.
- Trial name
- NCT04259697
- Testing
- Clinical pilates, Whole body vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Dokuz Eylul University
Bone, Growth
Zinc and Bone Turnover Study in Adolescent Females
The purpose of the study is to determine the effects of zinc supplementation on bone growth over four weeks. Participants will agree to attend two visits to our laboratory and at each will complete blood and urine samples…
- Conditions
- Bone, Growth, Osteoporosis
- Trial name
- NCT01892098
- Testing
- Zinc Sulfate
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Dimensional Alterations
Dimensional Soft and Hard Tissue Alterations Following Single Tooth Extraction in the Anterior Maxilla - A Prospective Clinical Study
Bone modeling after tooth extraction has a major consequence on implant therapy, in particular in the esthetic zone. In esthetic sites, no tissue loss should occur if an optimal esthetic outcome is expected.
- Trial name
- Alterations (NCT02403700)
- Testing
- Cone beam computed tomography (CBCT)
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Bern
Vitamin D Deficiency, Alveolar Bone Loss
Vit D and Post-extractive Bone Turnover
The aims of the study was to correlate the extent of the dimensional alveolar bone changes after tooth extraction and contextual guided bone regeneration with serum vit D levels in 14 patients.
- Conditions
- Vitamin D Deficiency, Alveolar Bone Loss, Alveolar Bone Resorption
- Trial name
- NCT06412705
- Testing
- Tooth extraction, guided bone regeneration and dental implant
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo
Breast Cancer
Anastrozole and Letrozole
Aromatase Inhibitors (AI) are effective for secondary prevention of breast cancer and may soon replace tamoxifen as first-line therapy in the treatment of hormone-sensitive breast cancer.
- Trial name
- NCT00762294
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UConn Health
Osteopenic Women
Effects of Turkish Traditional Dances on Postmenopausal Osteopenic Women
The aim of this study is to evaluate the effects of regular Turkish regional dances, in addition to conventional exercises given with a home program, on the quality of life, balance, aerobic capacity, bone mineral density…
- Trial name
- NCT07068113
- Testing
- DANCE GROUP, EXERCISE GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Ankara Etlik City Hospital
Bone Loss, Age-related
Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture
Gut microbiota regulate metabolism of their human host. Some diseases are associated with variations in gut microbiota diversity and higher fracture risk.
- Trial name
- MICROBONE (NCT04265742)
- Testing
- bone densitometry, High resolution peripheral QCT, Collection of biological samples
- Where
- France
- Volunteers
- 440 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Osteoporosis, Postmenopausal, Statin Therapy
Therapeutic Prospects of HMG-CoA Reductase Inhibitors, Atorvastatin and Rosuvastatin, in Osteoporotic Patients
Osteoporosis is one of the most common chronic skeletal disorders, particularly among postmenopausal women, and is associated with an increased risk of fragility fractures, disability, and reduced quality of life.
- Trial name
- statins on BMD (NCT07717788)
- Testing
- Alendronate 70 mg tablets, Atorvastatin, Rosuvastatin
- Where
- Iraq
- Volunteers
- 65 people
- Sponsor
- Alkufa university\\collage of pharmacy
Bone Remodeling Disorder, Child Development
Clinical and Genetic Markers of Bone Metabolism in Children Under One Year
The study of children under one year of age for molecular genetic testing-VDR (rs1544410, rs2228570), RANKL (rs9594738, rs9594759) with the study of the frequency distribution of alleles and genotypes by polymorphisms, analysis…
- Conditions
- Bone Remodeling Disorder, Child Development, Genetic Change
- Trial name
- NCT05375331
- Where
- Kazakhstan
- Volunteers
- 245 people
- Sponsor
- West Kazakhstan Medical University
Dietary Proteins, Acute Exercise
Protein Ingestion on BMM Response in Endurance Runners
The goal of this clinical trial is to investigate the effects of protein ingestion post-exercise on bone turnover markers. The main questions it aims to answer is: Does protein ingestion independently influence the bone metabolic…
- Conditions
- Dietary Proteins, Acute Exercise, Bone Diseases, Metabolic
- Trial name
- BonePRO (NCT06645119)
- Testing
- Whey Protein Supplement
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McGill University
Osteoporosis, Postmenopausal, Osteopenia
High-Intensity Laser Therapy and Physiotherapy for Bone Health in Postmenopausal Women: A Randomized Trial
The goal of this clinical trial is to learn if adding high-intensity laser therapy (HILT) to a physiotherapy programme helps bone health in women after menopause who have low bone density (osteopenia or osteoporosis).
- Trial name
- NCT07734922
- Testing
- High-Intensity Laser Therapy, Standardised Physiotherapy Programme
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Bone Diseases, Bone Cysts
Safety and Efficacy of Non-Setting Paste in Bone Defect Reconstruction
This study aims to evaluate the safety and efficacy of a novel bone substitute material for the treatment of bone defects in patients requiring defect filling following the excision of benign bone tumors, cysts, or similar…
- Conditions
- Bone Diseases, Bone Cysts, Bone Neoplasm, Enchondromatosis
- Trial name
- NCT07379008
- Testing
- Non-setting paste
- Where
- Poland
- Volunteers
- 29 people
- Sponsor
- Biovico Sp. z o.o.
Postmenopausal Osteopenia
The Effect of Aerobic Exercise on Bone Turnover Markers in Postmenopausal Patients
The aim of the study was to evaluate the effect of light-moderate aerobic exercise on BMD in postmenopausal osteopenic women using bone formation-resorption markers.
- Trial name
- NCT06866561
- Testing
- aerobic exercise, cholecalciferol, calcium carbonate
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Vitamin D Deficiency, Polytrauma
Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients
Although vitamin D is known to play a major role in multiple organ functions in healthy adults, including bone homeostasis, its role in the unique population of orthopaedic polytrauma patients has not been well described.
- Conditions
- Vitamin D Deficiency, Polytrauma, Orthopedic Disorder
- Trial name
- NCT03066817
- Testing
- Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL], Propylene Glycol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York City Health and Hospitals Corporation
Diabetes Complications, Osteoporosis
The Effect of Liraglutide on Bone Turnover, Bone Mass and Bone Cell Function
The purpose of this study is to test whether liraglutide, a drug approved and widely used in the treatment of type 2 diabetes, has an effect on bone mass and bone cell function.
- Trial name
- LIRABONE (NCT02473809)
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus