Clinical trials: Bone Regeneration, active
Bone Loss, Jaw, Edentulous
Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration
The objective of this study is to test the bone formation capacity of a 3D printed scaffold with a plastic material called Polycaprolactone (PCL), compared to the use of synthetic bone grafts, for bone formation in the maxilla or…
- Conditions
- Bone Loss, Jaw, Edentulous, Edentulous Mouth, Jaw Fractures
- Trial name
- OSTEOPRINT (NCT06773923)
- Testing
- PCL Scaffold, PTFE + Bio-Oss®
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Bone Resorption
Guided Bone Regeneration Using Fixed vs Non-Fixed Resorbable Collagen Membranes
The aim of this clinical trial is to compare the horizontal bone gain when grafting a bone substitute with non fixed resorbable collagen membranes (control group), versus fixed resorbable collagen membranes (test group) in…
- Trial name
- NCT06334159
- Testing
- Horizontal GBR with the use of non-resorbable pins for the stabilization of the collagen membrane, Horizontal GBR without the use of non-resorbable pins for the stabilization of the collagen membrane
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Bone Regeneration, Safety Issues
Evaluation of Performance, Safety and Benefit of the Wishbone HA as Bone Graft Substitute, a Pre-market Clinical Investigation
This investigation is a pre-market, prospective, multi-center, randomized, single blinded, parallel controlled clinical investigation performed in at least 5 clinical centers for confirmatory purposes of the use of WHA as…
- Trial name
- NCT06383377
- Testing
- Tooth extraction and bone graft procedure
- Where
- 5 sites in Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Wishbone SA
Intra-Bony Defects in Periodontitis Patients
The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects
The aim of this study will be to evaluate clinically, radiographically and biochemically the efficacy of exosomes combined with synthetic bone graft for the treatment of periodontal intra-bony defects.
- Trial name
- NCT07897292
- Testing
- single flap approach, single flap approach combined with nanocrystalline hydroxyapatite bone substitute, Exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khoshoe Al-mokhtar Mohammed
Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone
Clinical and Radiographic Evaluation of CGF and Alloplastic Grafting in Participants Undergoing the Socket Shield Technique for Immediate Anterior Maxillary Implant Placement. This Study Assesses Bone Healing and Stability When Managing the Crestal Gap in the Esthetic Zone.
The goal of this clinical trial is to evaluate the clinical and radiographic effectiveness of the socket shield technique combined with concentrated growth factor (CGF) and alloplastic graft in promoting bone healing and…
- Conditions
- Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone, Socket Shield Technique, Partial Extraction Therapy
- Trial name
- CGF (NCT07514871)
- Testing
- Socket Shield Technique with CGF and Alloplastic Graft.
- Where
- Egypt
- Volunteers
- 7 people
- Sponsor
- Cairo University
Dental Implants, Single-tooth, Alveolar Ridge Preservation
Alveolar Ridge Preservation Versus Spontaneous Healing
Rationale: To determine the effect of alveolar ridge preservation (ARP) versus spontaneous healing (SH) in large buccal bone defects in the posterior mandible.
- Conditions
- Dental Implants, Single-tooth, Alveolar Ridge Preservation, Guided Bone Regeneration
- Trial name
- ARP versus SH (NCT07001345)
- Testing
- Alveolar Ridge Reconstruction
- Where
- Netherlands
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Horizontal Alveolar Ridge Deficiency
Comparison of Three Autogenous Bone and Xenograft Ratios for Horizontal Ridge Augmentation
This study will compare three different ratios of autogenous bone and xenograft used for horizontal alveolar ridge augmentation in patients with insufficient bone width for dental implant placement.
- Trial name
- NCT07869485
- Testing
- 50:50 Autogenous Bone-Xenograft, 75:25 Autogenous Bone-Xenograft, 25:75 Autogenous Bone-Xenograft
- Volunteers
- 45 people
- Sponsor
- Eslam hisham mohamed
Guided Bone Regeneration, Bone Resorption
The Effect of IPD on Lateral Bone Augmentation
Guided Bone Regeneration (GBR) is a widely used technique during dental implant surgery to help rebuild bone around the implant and improve its long-term appearance and stability.
- Conditions
- Guided Bone Regeneration, Bone Resorption, Diagnostic Imaging
- Trial name
- NCT06999915
- Testing
- Group 1 (Test Group): IP and GBR as an over-contour augmentation beyond IPD, Group 2 (Control Group): IP and GBR as a contour augmentation up to IPD
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Queen Mary University of London
Jaw Cysts, Metformin
Osteogenic Potential of Topical Metformin Gel on Cystic Jaw Defects
Evaluate the osteogenic effect of locally applied 1% metformin gel on bone volume formation after jaw cystic defects enucleation
- Conditions
- Jaw Cysts, Metformin, Inflammatory Cyst, Cyst Enucleation
- Trial name
- NCT07867236
- Testing
- For the Experimental Arm: 1% Metformin Gel
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Alveolar Bone Deficiency
Long-Term Stability of Soft and Hard Tissues After Guided Bone Regeneration in the Maxillary Anterior Region
This study examines the long-term condition of bone and gum tissues around dental implants in the upper front jaw after guided bone regeneration (GBR), a procedure used to rebuild bone at implant sites.
- Trial name
- NCT07893873
- Testing
- Guided Bone Regeneration
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fuming He
Immediate Dental Implant Placement, Connective Tissue Graft
Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study
This clinical trial investigates the biological and clinical outcomes of immediate implant placement in aesthetic areas presenting with buccal bone dehiscence.
- Conditions
- Immediate Dental Implant Placement, Connective Tissue Graft, Connective Tissue Graft Harvesting, Soft Tissue Management in Subcrestal Dental Implants
- Trial name
- GBR / RCT (NCT07415486)
- Testing
- immediate implant placement with DBBM-C and connective tissue graft, immediate implant placement with DBBM-C with collagen membrane
- Volunteers
- 24 people
- Sponsor
- Universitat Internacional de Catalunya
Alveolar Bone Loss* / Therapy
Study on Silk Fibroin-Reinforced Collagen-Based Composite Membrane for Periodontal Bone Tissue Regeneration
Based on the mechanism of intramembranous ossification of the alveolar bone, it is necessary to design a biomimetic membrane material based on the principle of GBR (Guided Bone Regeneration) to simulate the biological…
- Trial name
- NCT07574853
- Testing
- Silk Fibroin-Reinforced Collagen-Based Composite Membrane
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Horizontal Ridge Deficiency
Implant Phenotype Modification Via GBR and ADM
Single implant sites with bone loss can often be managed by bone grafting alone. The purpose of this study is to determine whether putting a soft tissue graft substitute over the bone graft will provide an increased benefit for…
- Trial name
- NCT07082244
- Testing
- Dental implant placement, Guided bone regeneration with collagen membrane, Guided bone regeneration with acellular dermal matrix.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Tooth Extraction, Tooth Replacement
Comparison of Two Collagen Membranes for Bone Augmentation Around Dental Implants Restored with Monolithic Zirconia Single Crowns
The goal of this randomized controlled clinical trial is to compare the use of two covering collagen membranes in a bone augmentation procedure around single implants and to assess three different veneering approaches on crowns…
- Trial name
- BioGide-Compr (NCT06724783)
- Testing
- Collagen membrane
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- Dr. med. dent. Malin Strasding
Alveolar Bone Regeneration, Advanced Platelet-Rich Fibrin
Alveolar Bone Regeneration Using Advanced Platelet-Rich Fibrin Combined With Strontium-Doped Hydroxyapatite
This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with…
- Conditions
- Alveolar Bone Regeneration, Advanced Platelet-Rich Fibrin, Strontium-Doped Hydroxyapatite
- Trial name
- NCT07918014
- Testing
- Advanced Platelet-Rich Fibrin, Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite, Heal spontaneously without placement of any grafting material
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kafrelsheikh University
Bone Defect
FlexiOss® - Efficacy, Safety and Long-term (Radiological and Clinical) Outcomes During Comprehensive Care Continuum of Implanted Biocomposite for Bone Regeneration.
The aim of this clinical study is to evaluate the efficacy, safety and long-term (radiological and clinical) outcomes during comprehensive care continuum of implanted biocomposite for bone regeneration FlexiOss® compared to the…
- Trial name
- FlexiOssOT (NCT07209033)
- Testing
- FlexiOss®, Allogenic human bone grafting
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- Medical Inventi S.A.
Insufficient Bone Volume Prior to Implant Surgery
The Tooth Collar Technique
The aim of this study is to evaluate wound healing after the application of the Tooth Collar Technique (TCT) for bone augmentation in the upper or lower jaw.
- Trial name
- TCTechnique (NCT07753525)
- Testing
- Tooth Collar Technique
- Where
- 4 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Periapical Lesions
Evaluation of Bone Regeneration After Apical Surgery Using Advanced Platelet-rich Fibrin: Utilization of Ultrasound for the Assessment of Periapical Lesions
The study examines the impact of advanced platelet-rich fibrin (A-PRF) on bone regeneration in apical surgery compared to standard methods.
- Trial name
- EBRAAPUU (NCT06734962)
- Testing
- Apical surgery procedure using A-PRF, Apical surgery without using A-PRF
- Where
- Latvia
- Volunteers
- 44 people
- Sponsor
- Riga Stradins University
Horizontal Alveolar Ridge Deficiency
Comparison of Two Autogenous Bone and Xenograft Ratios for Horizontal Ridge Augmentation
This pilot randomized controlled clinical study will evaluate horizontal bone gain in patients with deficient alveolar ridges requiring horizontal ridge augmentation.
- Trial name
- NCT07865624
- Testing
- 50:50 Autogenous Bone-Xenograft, 75:25 Autogenous Bone-Xenograft
- Volunteers
- 30 people
- Sponsor
- Eslam hisham mohamed
Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use
Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative
The goal of this clinical trial is to radiographically assess the effectiveness of minimally invasive non-surgical technique (MINST) combined with local administration of sodium hypochlorite gel (Perisolv®) and 1.6% cross-linked…
- Conditions
- Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy, Hyaluronic Acid* / Therapeutic Use
- Trial name
- NCT07339605
- Testing
- Flapless instrumentation of the defect following MINST in conjuction with NaOCl and hyaluronic acid application, Flapless instrumentation of the defect following MINST, root conditioning with EDTA and EMD application, Flapless instrumentation of the defect and product application simulation
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia