Alveolar Ridge ResorptionCGFNCT07514871
Clinical and Radiographic Evaluation of CGF and Alloplastic Grafting in Participants Undergoing the Socket Shield Technique for Immediate Anterior Maxillary Implant Placement. This Study Assesses Bone Healing and Stability When Managing the Crestal Gap in the Esthetic Zone.
A study testing Socket Shield Technique with CGF and Alloplastic Graft. in people with Alveolar Ridge Resorption and Bone Loss in the Esthetic Zone, run by Cairo University at 1 site in Egypt.
Trial summary
The goal of this clinical trial is to evaluate the clinical and radiographic effectiveness of the socket shield technique combined with concentrated growth factor (CGF) and alloplastic graft in promoting bone healing and achieving successful immediate implant placement in the esthetic zone. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone, Socket Shield Technique
- What is being tested?
- Socket Shield Technique with CGF and Alloplastic Graft.
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 7 participants
- Where
- 1 siteEgypt
- Study dates
- 25 Apr 2026to 1 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants must be 18 years of age or older.
- Both male and female patients.
- Maxillary, anterior and premolar segments.
Who cannot join
- A medical history that contraindicates oral surgical treatment (uncontrolled/untreated diabetes mellitus, immuno-compromised status, radio/chemotherapy of the oral and maxillofacial region, treatment with oral and/or intravenous amino-bisphosponates).
- Untreated periodontal disease.
- Vertical root fractures on the buccal aspect.
- Tooth /teeth with horizontal fractures below bone level.
- Tooth /teeth with external or internal resorptions.
- Patients with any oral destructive habits such as smoking, chewing tobacco, bruxism, etcetera.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Faculty of Dentistry
Cairo, Cairo Governorate, 12613
Ibrahim Ahmad Anas Jadoo
About this study
Official title: Clinical and Radiographic Evaluation of Bone Grafting Using CGF and Alloplastic Graft With Simultaneous Immediate Implant Placement in Socket Shield Technique (Case Series Study).
The goal of this clinical trial is to evaluate the clinical and radiographic effectiveness of the socket shield technique combined with concentrated growth factor (CGF) and alloplastic graft in promoting bone healing and achieving successful immediate implant placement in the esthetic zone.
This prospective case series involves both male and female participants aged 18 years or older who require immediate implant placement in the maxillary anterior segments. The main questions it aims to answer are :
Read more
Does the combined use of CGF and alloplastic grafting materials with the socket shield technique improve crestal bone levels as measured by CBCT?
How does this intervention affect secondary outcomes such as primary implant stability measured via the Osstell implant stability quotient?
Participants will: Undergo a socket shield procedure (partial extraction therapy) where the labial root fragment is retained to preserve the buccal bone. Provide a blood sample for the preparation of autologous CGF. Receive simultaneous immediate implant placement. Have a "sticky bone" mixture of CGF and alloplastic graft packed into the jumping gap around the implant. Attend follow-up appointments for clinical assessments and CBCT imaging at 2 weeks and 6 months post-operatively.
Read the detailed description
This prospective case series investigates the synergistic effect of Concentrated Growth Factor (CGF) and alloplastic bone substitutes within the Socket Shield Technique. The primary clinical challenge addressed is the "jumping distance" or crestal gap that naturally forms between an implant and the extraction socket wall. While SST is designed to prevent the resorption of the buccal bundle bone by retaining a root fragment, this study explores whether the biological enhancement of CGF can further optimize the regenerative environment .Technical Procedure and Biological Rationale The surgical protocol utilizes a Partial Extraction Therapy approach where the tooth crown is decapitated and the root is sectioned mesiodistally. A labial shield is maintained to provide structural support to the labial bone plate. Following a standard osteotomy, the "sticky bone" complex is prepared .The Concentrated Growth Factor (CGF) is produced using a specialized centrifuge with a variable spin-speed protocol, which results in a denser fibrin network compared to first or second-generation platelet concentrates. This matrix allows for the sustained release of essential signaling molecules to promote osteogenesis and soft tissue regeneration. Regenerative Synergy The intervention combines the biological activity of the autologous CGF with the osteoconductive properties of an alloplastic graft. While the alloplastic material provides a stable, predictable scaffold to maintain space and volume within the jumping gap, the CGF accelerates the early stages of healing and bone formation. This combination is hypothesized to provide superior mechanical and biological properties for long-term stability in the esthetic zone .Clinical Monitoring Following immediate temporization, participants enter a strict plaque control regimen. Longitudinal evaluation is performed using limited-field Cone-Beam Computed Tomography (CBCT) to quantify changes in bone volume and integration. These scans are conducted at specific intervals to monitor the transition from early healing to the final bone remodeling phase prior to definitive prosthetic loading.
- Conditions
- Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone, Socket Shield Technique, Partial Extraction Therapy, Immediate Dental Implant Placement, Bone Regeneration Using Concentrated Growth Factor
- Being tested
- Socket Shield Technique with CGF and Alloplastic Graft.
- Keywords
- Socket Shield Technique, Partial Extraction Therapy, Concentrated Growth Factor (CGF), Alloplastic Bone Graft, Sticky Bone
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Socket Shield Technique with CGF and Alloplastic Graft.Procedure or surgery
The intervention consists of a specialized surgical and regenerative protocol that combines the Socket Shield Technique with the application of a "sticky bone" complex for simultaneous immediate implant placement. Unlike conventional extraction, this partial extraction therapy involves decapitating the tooth crown and sectioning the root mesiodistally to retain a labial segment, which is remains firmly attached to the buccal bone to provide structural support. Following the immediate insertion of the dental implant, a third-generation platelet concentrate known as Concentrated Growth Factor (CGF) is prepared from the patient's blood using a variable spin-speed centrifuge to create a dense fibrin network rich in growth factors. This autologous CGF is then combined with a synthetic alloplastic bone graft to form the "sticky bone" mixture, which is carefully packed into the "jumping gap" between the implant periphery and the retained labial shield to facilitate enhanced bone regeneration
| Study group | Role | What they receive |
|---|---|---|
| Socket Shield Technique with CGF and Alloplastic Graft | Experimental | In this single-group prospective case series, participants undergo the Socket Shield Technique (partial extraction therapy) for simultaneous immediate implant placement in the maxillary anterior segments. The surgical intervention involves decapitating the tooth crown and sectioning the root mesiodistally to retain a labial segment that is remains firmly attached to the buccal bone. After the implant is inserted into the prepared site, a "sticky bone" complex is prepared by centrifuging a 10 mL sample of the patient's blood to extract autologous Concentrated Growth Factor (CGF). This CGF fibrin matrix is combined with an alloplastic bone graft and carefully packed into the "jumping gap" between the implant periphery and the surrounding bone to facilitate enhanced bone regeneration and healing. Follow-up includes immediate temporization and longitudinal monitoring of crestal bone levels and implant stability via CBCT and Osstell. Receives: Procedure: Socket Shield Technique with CGF and Alloplastic Graft. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Crestal Bone Level
The primary outcome is the radiographic assessment of the Change in Crestal Bone Level, measured in millimeters using Limited-field Cone-Beam Computed Tomography (CBCT). This evaluation focuses on the vertical bone dimensions surrounding the dental implant.
Measured: From 2 weeks post-operatively to 6 months post-operatively.
Secondary outcomes (1)
Primary Implant Stability
This outcome measures the stability of the dental implant using Resonance Frequency Analysis via the Osstell device. The stability is quantified as an ISQ value on a scale of 1 to 100. Higher values indicate greater implant stability and better osseointegration. Measurements are taken to evaluate primary stability (at the time of implant placement) , providing a clinical assessment of how effectively the "sticky bone" (CGF and alloplastic graft) and the socket shield have supported the integration of the implant within the maxillary bone.
Measured: From the time of implant placement (Day 0) to 6 months post-operatively.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Apr 2026
- Study start25 Apr 2026 (estimated)
- Primary completion1 Oct 2026 (estimated)
- Study completion1 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Ridge ResorptionStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 7 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, IBRAHIM AHMAD ANAS JADOO, Cairo University
- Investigators
- Tarek El-Ghareeb, professor, Study chair, Cairo UniversityAbdelmoez Mohamed El-Sharkawy, Associate Professor, Study director, Cairo UniversityIbrahim Ahmad Anas Jadoo, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07514871
- Sponsor's protocol ID
- 3-3-20
- Acronym
- CGF
- Status last verified
- Jul 2025
- First submitted
- 31 Mar 2026
- Last updated
- 7 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Radiographic Evaluation of Bone Grafting Using CGF and Alloplastic Graft With Simultaneous Immediate Implant Placement in Socket Shield Technique (Case Series Study).
- ClinicalTrials.gov ID
- NCT07514871
- Acronym / sponsor ID
- CGF / 3-3-20
- Conditions
- Alveolar Ridge Resorption, Bone Loss in the Esthetic Zone, Socket Shield Technique, Partial Extraction Therapy, Immediate Dental Implant Placement, Bone Regeneration Using Concentrated Growth Factor
- Keywords
- Socket Shield Technique, Partial Extraction Therapy, Concentrated Growth Factor (CGF), Alloplastic Bone Graft, Sticky Bone
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 7 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 25 Apr 2026 (estimated)
- Primary completion
- 1 Oct 2026 (estimated)
- Study completion
- 1 Nov 2026 (estimated)
- First posted
- 7 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate the clinical and radiographic effectiveness of the socket shield technique combined with concentrated growth factor (CGF) and alloplastic graft in promoting bone healing and achieving successful immediate implant placement in the esthetic zone.
This prospective case series involves both male and female participants aged 18 years or older who require immediate implant placement in the maxillary anterior segments. The main questions it aims to answer are :
Does the combined use of CGF and alloplastic grafting materials with the socket shield technique improve crestal bone levels as measured by CBCT?
How does this intervention affect secondary outcomes such as primary implant stability measured via the Osstell implant stability quotient?
Participants will: Undergo a socket shield procedure (partial extraction therapy) where the labial root fragment is retained to preserve the buccal bone. Provide a blood sample for the preparation of autologous CGF. Receive simultaneous immediate implant placement. Have a "sticky bone" mixture of CGF and alloplastic graft packed into the jumping gap around the implant. Attend follow-up appointments for clinical assessments and CBCT imaging at 2 weeks and 6 months post-operatively.
Detailed description
This prospective case series investigates the synergistic effect of Concentrated Growth Factor (CGF) and alloplastic bone substitutes within the Socket Shield Technique. The primary clinical challenge addressed is the "jumping distance" or crestal gap that naturally forms between an implant and the extraction socket wall. While SST is designed to prevent the resorption of the buccal bundle bone by retaining a root fragment, this study explores whether the biological enhancement of CGF can further optimize the regenerative environment .Technical Procedure and Biological Rationale The surgical protocol utilizes a Partial Extraction Therapy approach where the tooth crown is decapitated and the root is sectioned mesiodistally. A labial shield is maintained to provide structural support to the labial bone plate. Following a standard osteotomy, the "sticky bone" complex is prepared .The Concentrated Growth Factor (CGF) is produced using a specialized centrifuge with a variable spin-speed protocol, which results in a denser fibrin network compared to first or second-generation platelet concentrates. This matrix allows for the sustained release of essential signaling molecules to promote osteogenesis and soft tissue regeneration. Regenerative Synergy The intervention combines the biological activity of the autologous CGF with the osteoconductive properties of an alloplastic graft. While the alloplastic material provides a stable, predictable scaffold to maintain space and volume within the jumping gap, the CGF accelerates the early stages of healing and bone formation. This combination is hypothesized to provide superior mechanical and biological properties for long-term stability in the esthetic zone .Clinical Monitoring Following immediate temporization, participants enter a strict plaque control regimen. Longitudinal evaluation is performed using limited-field Cone-Beam Computed Tomography (CBCT) to quantify changes in bone volume and integration. These scans are conducted at specific intervals to monitor the transition from early healing to the final bone remodeling phase prior to definitive prosthetic loading.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Socket Shield Technique with CGF and Alloplastic Graft | Experimental | Procedure: Socket Shield Technique with CGF and Alloplastic Graft.In this single-group prospective case series, participants undergo the Socket Shield Technique (partial extraction therapy) for simultaneous immediate implant placement in the maxillary anterior segments. The surgical intervention involves decapitating the tooth crown and sectioning the root mesiodistally to retain a labial segment that is remains firmly attached to the buccal bone. After the implant is inserted into the prepared site, a "sticky bone" complex is prepared by centrifuging a 10 mL sample of the patient's blood to extract autologous Concentrated Growth Factor (CGF). This CGF fibrin matrix is combined with an alloplastic bone graft and carefully packed into the "jumping gap" between the implant periphery and the surrounding bone to facilitate enhanced bone regeneration and healing. Follow-up includes immediate temporization and longitudinal monitoring of crestal bone levels and implant stability via CBCT and Osstell. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Participants must be 18 years of age or older.
- Both male and female patients.
- Maxillary, anterior and premolar segments.
Key exclusion criteria (6 listed)
- A medical history that contraindicates oral surgical treatment (uncontrolled/untreated diabetes mellitus, immuno-compromised status, radio/chemotherapy of the oral and maxillofacial region, treatment with oral and/or intravenous amino-bisphosponates).
- Untreated periodontal disease.
- Vertical root fractures on the buccal aspect.
- Tooth /teeth with horizontal fractures below bone level.
- Tooth /teeth with external or internal resorptions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Socket Shield Technique with CGF and Alloplastic Graft.The intervention consists of a specialized surgical and regenerative protocol that combines the Socket Shield Technique with the application of a "sticky bone" complex for simultaneous immediate implant placement. Unlike conventional extraction, this partial extraction therapy involves decapitating the tooth crown and sectioning the root mesiodistally to retain a labial segment, which is remains firmly attached to the buccal bone to provide structural support. Following the immediate insertion of the dental implant, a third-generation platelet concentrate known as Concentrated Growth Factor (CGF) is prepared from the patient's blood using a variable spin-speed centrifuge to create a dense fibrin network rich in growth factors. This autologous CGF is then combined with a synthetic alloplastic bone graft to form the "sticky bone" mixture, which is carefully packed into the "jumping gap" between the implant periphery and the retained labial shield to facilitate enhanced bone regeneration | Procedure or surgery | Socket Shield Technique with CGF and Alloplastic Graft |
Primary outcome
Change in Crestal Bone Level
Time frame: From 2 weeks post-operatively to 6 months post-operatively.
The primary outcome is the radiographic assessment of the Change in Crestal Bone Level, measured in millimeters using Limited-field Cone-Beam Computed Tomography (CBCT). This evaluation focuses on the vertical bone dimensions surrounding the dental implant.
1 secondary outcome
Primary Implant Stability
Time frame: From the time of implant placement (Day 0) to 6 months post-operatively.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Apr 2026.
Related trials for Alveolar Ridge Resorption
Active, not recruiting
L-PRF Block vs Composite Graft for Horizontal Ridge Augmentation
Alveolar Ridge Resorption After Extraction, Alveolar Bone Loss
Not yet recruitingPhase 1/2
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
Alveolar Ridge Augmentation, Bone Substitutes
Recruiting
Different Approaches for Alveolar Ridge Preservation
Alveolar Ridge Resorption
Recruiting
Volumetric Efficacy of Alveolar Ridge Preservation
Alveolar Ridge Preservation, Tooth Loss
Recruiting
THBC/CGF for Alveolar Bone Regeneration: A Real-World Study
Alveolar Bone Loss, Alveolar Ridge Resorption After Extraction
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Tarek El-Ghareeb, professor study chair
Cairo University
Abdelmoez Mohamed El-Sharkawy, Associate Professor study director
Cairo University
Ibrahim Ahmad Anas Jadoo principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Socket Shield Technique with CGF and Alloplastic Graft. in people with Alveolar Ridge Resorption and Bone Loss in the Esthetic Zone, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ibrahim Ahmad Anas Jadoo (+201094027357, ibrahim.jadoo@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Crestal Bone Level (time frame: From 2 weeks post-operatively to 6 months post-operatively.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Apr 2026; AzTrials last refreshed its copy on 8 Nov 2026.