Clinical trials: Bone Mass, active
Hematologic Diseases, Chronic Myeloid Leukemia
Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant
PURPOSE: To investigate the effect of the disease and HSCT on muscle dysfunction and to investigate the prognostic role of muscle dysfunction at critical decision points in patients with hematological diseases referred to…
- Conditions
- Hematologic Diseases, Chronic Myeloid Leukemia, Acute Myeloid Leukemia, Acute Lymphoid Leukemia
- Trial name
- NCT04167683
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 144 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bone Density, Bone Health
VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone (VITAL)
Vitamin D supplements are widely promoted for bone health. Both vitamin D and vitamin K are important for deposition of calcium in bone, but little is known about the relationship of vitamin K status and bone health.
- Conditions
- Bone Density, Bone Health, Fractures
- Trial name
- NCT04573946
- Testing
- Omega-3 fatty acids (fish oil), Vitamin D3
- Where
- United States
- Volunteers
- 25,871 people
- Sponsor
- Brigham and Women's Hospital
Osteoporosis
The Effect of Factors Affecting Bone Mineral Density Measurement Results on Osteoporosis Diagnosis and Treatment Decision
This is a single-center prospective cross-sectional study with a follow-up period of 6 months. All patients met the inclusion criteria and requested DXA at the outpatient clinics of Ankara Etlik City Hospital Physical Therapy and…
- Trial name
- NCT07812402
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Osteoporosis, Osteopenia
Serum Myostatin and Irisin Levels in Postmenopausal Women: Association With Bone Mineral Density and Muscle Strength
This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women.
- Trial name
- MYOIRISIN (NCT07519551)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Chronic Stroke, CONUT Score
Evaluation Of The Relationship Between The Conut Score And Balance And Functional Status In Patients With Chronic Stroke
The primary aim of this study is to evaluate the relationship between the CONUT score, which reflects nutritional status, and balance performance in patients with chronic stroke.
- Conditions
- Chronic Stroke, CONUT Score, Balance Assessment, Functional Status
- Trial name
- NCT07468110
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Marmara University
Low Bone Mineral Density, Muscle Oxygenation
Bone and Muscle Oxygenation in Military Test Pilots
This prospective, single-group interventional pilot study will evaluate the effects of a 12-week resistance and core stabilization exercise program on bone mineral density and resting muscle oxygenation in male military test…
- Trial name
- BMO-MTP (NCT07787143)
- Testing
- Supervised Resistance and Core Stabilization Exercise Program
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emine Merve Ersever
Osteoporosis
The Effect of Denosumab on Muscle and Strength and Insulin Sensitivity
Randomized, placebo controlled prospective trial evaluating the effect of denosumab on insulin sensitivity and muscle strength.
- Trial name
- DENMUSIN (NCT07271771)
- Testing
- Denosumab, Saline (0.9% NaCl)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
Body Composition, Muscle Function
GLP-1RA Effects on Lean Mass and Bone Health in Midlife Women
This study is designed with the interest to learn on the effects of estrogen levels and how it affects body compositions and muscle function in midlife women who are taking a GLP-1RA for weight loss.
- Conditions
- Body Composition, Muscle Function, GLP-1, Estrogen Level
- Trial name
- GLOW (NCT07422987)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Osteopenia
AI-Supported Mobile High-Impact and Strengthening Exercise Program in Postmenopausal Women With Low Bone Density
Low bone mineral density after menopause increases the risk of osteoporosis and fractures, and regular exercise can help preserve bone health. However, adherence to home exercise programs is often low.
- Trial name
- NCT07918716
- Testing
- AI-Supported Mobile Health Application, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Istanbul University
Immediate Implant Placement, Melatonin Production
Effectiveness of Topical Application of Melatonin On Bone Density and Implant Stability In Immediate Implantation
Dental implants have revolutionized the replacement of missing teeth, offering predictable and long-lasting rehabilitation for both fully and partially edentulous patients.
- Trial name
- NCT07003243
- Testing
- Local melatonin powder
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Calcium, Osteoporosis
A Study of Amorphous Calcium Carbonate in Postmenopausal Women
Using the FREEDOM substudy as a benchmark, evaluate the effects of amorphous calcium carbonate (ACC) on bone mineral density (BMD) in postmenopausal women, both with and without the combination of Denosumab treatment.
- Conditions
- Calcium, Osteoporosis, Bone Mineral Density, Bone Turnover Marker
- Trial name
- NCT06728462
- Testing
- Amorphous calcium carbonate
- Where
- Taiwan
- Volunteers
- 205 people
- Sponsor
- Universal Integrated Corp.
Marfan Syndrome
Marfan Syndrome Moderate Exercise Trial II
Marfan syndrome (MFS) is a distinctive connective tissue disorder that affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection.
- Trial name
- NCT05809323
- Testing
- Exercise Intervention Group, Control Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Osteoporosis, Postmenopausal Osteoporosis
Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?
Osteoporosis is a major cause of morbidity and fragility fractures in postmenopausal women. Bone mineral density (BMD) alone may not fully reflect fracture risk and skeletal fragility.
- Conditions
- Osteoporosis, Postmenopausal Osteoporosis, Frailty, Fragility Fractures
- Trial name
- LUMINOS (NCT07677072)
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Non-small Cell Lung Cancer
Efficacy and Safety of HGXJT in Bone Metastatic NSCLC Patients
This is a double-blind, randomized controlled study evaluating the efficacy and safety of HGXJT in combination with ICI-based standard treatment in lung cancer patients with bone metastases.
- Trial name
- NCT05378334
- Testing
- ICI, Chemotherapy, Bone-protecting and Mass-dispersesing Decoction
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Weight Loss, Bone Density
Metabolic Health, Bones and Nuts During Weight Loss in Adults
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group.
- Conditions
- Weight Loss, Bone Density, Obesity and Overweight
- Trial name
- BERN (NCT06949280)
- Testing
- Peanut Snack Experimental, Nut-free Snack
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Osteoporosis in Post-menopausal Women
Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause.
- Trial name
- BEAT-OP (NCT07267325)
- Testing
- EXERCISE TRAINING, Antiresorptive medication (routine clinical care)
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Healthy, Indicated for EOSedge Imaging
Bone Mineral Density Agreement Study Between EOSedge™ Versus Traditional DXA
The purpose of this research is to collect medical imaging data to allow for the comparison of bone mineral density measurements from two different types of low-dose x-ray exams, EOSedge and conventional DXA.
- Trial name
- NCT06659055
- Testing
- DXA Imaging, EOSedge imaging
- Where
- 4 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Alphatec Spine, Inc.
Osteoporosis
Calibr-Ì: Comparative Evaluation of Phantomless Calibration Methods to Quantify Bone Mineral Density for Opportunistic Analysis of CT Scans
Osteoporosis is a systemic disease characterized by a reduction in bone mineral density (BMD) and qualitative alteration of the skeleton, resulting in increased bone fragility and fracture risk.
- Trial name
- Calibr-Ì (NCT06454617)
- Testing
- Phantom
- Where
- 2 sites in Italy, New Zealand
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli