Low Bone Mineral DensityBMO-MTPNCT07787143
Bone and Muscle Oxygenation in Military Test Pilots
A study testing Supervised Resistance and Core Stabilization Exercise Program in people with Low Bone Mineral Density and Muscle Oxygenation, run by Emine Merve Ersever.
Trial summary
This prospective, single-group interventional pilot study will evaluate the effects of a 12-week resistance and core stabilization exercise program on bone mineral density and resting muscle oxygenation in male military test pilots with low baseline bone mineral density. Read more about this study
- Who is it for?
- Ages 18 to 50 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Low Bone Mineral Density, Muscle Oxygenation
- What is being tested?
- Supervised Resistance and Core Stabilization Exercise Program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- No sites listed yet
- Study dates
- 15 Sep 2026to 15 Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male military test pilots with previous military aviation experience Low bone mineral density identified by dual-energy X-ray absorptiometry (DXA) Regular participation in flight duties Medical fitness to participate in regular exercise training Willingness to participate in the 12-week supervised resistance and core stabilization exercise program Ability to provide written informed consent
Who cannot join
- Acute musculoskeletal injury Recent orthopedic surgery Neurological disorder Cardiovascular disease Any medical condition that limits participation in physical exercise Subcutaneous adipose tissue thickness greater than 17.5 mm at the NIRS measurement site
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Bone Mineral Density and Resting Muscle Oxygenation Responses to a 12-Week Resistance and Core Stabilization Program in Military Test Pilots: Preliminary Findings
This prospective, single-group interventional pilot study will evaluate the effects of a 12-week resistance and core stabilization exercise program on bone mineral density and resting muscle oxygenation in male military test pilots with low baseline bone mineral density. Participants will complete a supervised exercise program five days per week for 12 weeks while continuing their routine flight duties. Bone mineral density will be assessed using dual-energy X-ray absorptiometry, and resting muscle oxygenation will be evaluated in the vastus lateralis and rectus abdominis using near-infrared spectroscopy before and after the intervention. The study aims to characterize preliminary skeletal and muscle oxygenation responses to structured exercise in this specialized aviation population.
- Conditions
- Low Bone Mineral Density, Muscle Oxygenation
- Being tested
- Supervised Resistance and Core Stabilization Exercise Program
- Keywords
- Military aviation, Low bone mineral density, Near-infrared spectroscopy, Muscle oxygenation, Resistance training
- Medical subject headings
- Bone Diseases, Metabolic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Supervised Resistance and Core Stabilization Exercise ProgramBehavioural
Participants will undergo a 12-week physiotherapist-supervised resistance and core stabilization exercise program performed five days per week for approximately 120 minutes per session. The program will progress through three phases: adaptation (weeks 1-4, approximately 60% of one-repetition maximum [1RM]), strength development (weeks 5-8, 70-75% 1RM), and high-load neuromuscular control (weeks 9-12, 80-85% 1RM). The intervention will include multi-joint lower-extremity exercises (squat and deadlift), core stabilization exercises (plank, side plank, bird-dog, dead bug, and posterior pelvic tilt), and posterior-chain exercises (lunges, hip thrusts, and back extensions). Exercise tempo and rest intervals will be standardized, and training loads will be individually adjusted according to participant performance and tolerance
| Study group | Role | What they receive |
|---|---|---|
| Resistance and Core Stabilization Exercise Program | Experimental | Participants will complete a 12-week supervised resistance and core stabilization exercise program, performed five days per week for approximately 120 minutes per session. The program will progress through three phases: adaptation (weeks 1-4, approximately 60% of one-repetition maximum), strength development (weeks 5-8, 70-75% of one-repetition maximum), and high-load neuromuscular control (weeks 9-12, 80-85% of one-repetition maximum). The intervention will include multi-joint lower-extremity exercises such as squats and deadlifts, core stabilization exercises including planks, side planks, bird-dog, dead bug, and posterior pelvic tilt, and posterior-chain exercises such as lunges, hip thrusts, and back extensions. All sessions will be supervised by a physiotherapist, and training loads will be adjusted according to participant performance and tolerance Receives: Behavioral: Supervised Resistance and Core Stabilization Exercise Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Bone Mineral Density
BMD will be assessed by DXA at lumbar spine and proximal femoral sites and recorded in g/cm². Change from baseline to 12 weeks will be evaluated.
Time Frame: Baseline and 12 weeks
Measured: Baseline and 12 weeks
Change in Resting Muscle Oxygen Saturation (SmO₂)
Resting muscle oxygen saturation will be measured using NIRS in the vastus lateralis and rectus abdominis and reported as percentage (%). Change from baseline to 12 weeks will be evaluated.
Measured: Baseline and 12 weeks
Change in Total Haemoglobin (tHb)
Resting total haemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Measured: Baseline and 12 weeks
Change in Oxyhaemoglobin (O₂Hb)
Resting oxyhaemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Measured: Baseline and 12 weeks
Change in Deoxyhaemoglobin (HHb)
Resting deoxyhaemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Measured: Baseline and 12 weeks
Change in Haemoglobin Difference (HbDiff)
Resting haemoglobin difference will be derived from NIRS measurements in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Measured: Baseline and 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2026
- Study start15 Sep 2026 (estimated)
- Primary completion15 Dec 2026 (estimated)
- Study completion15 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Low Bone Mineral DensityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- All participants will receive the same 12-week supervised resistance and core stabilization exercise program. Outcomes will be assessed before and after the intervention, with no parallel control or comparison group.
- Masking
- None (open label)
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Emine Merve Ersever
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Emine Merve Ersever, Ankara University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07787143
- Sponsor's protocol ID
- E-2406515-169
- Acronym
- BMO-MTP
- Status last verified
- Aug 2026
- First submitted
- 11 Aug 2026
- Last updated
- 26 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Tuesta M, Yanez-Sepulveda R, Verdugo-Marchese H, Mateluna C, Alvear-Ordenes I. Near-Infrared Spectroscopy Used to Assess Physiological Muscle Adaptations in Exercise Clinical Trials: A Systematic Review. Biology (Basel). 2022 Jul 19;11(7):1073. doi: 10.3390/biology11071073.
PubMed 36101451Marshall RA, Mandell JC, Weaver MJ, Ferrone M, Sodickson A, Khurana B. Imaging Features and Management of Stress, Atypical, and Pathologic Fractures. Radiographics. 2018 Nov-Dec;38(7):2173-2192. doi: 10.1148/rg.2018180073.
PubMed 30422769
Study at a glance
From the registry record, last updated by the sponsor on 26 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Bone Mineral Density and Resting Muscle Oxygenation Responses to a 12-Week Resistance and Core Stabilization Program in Military Test Pilots: Preliminary Findings
- ClinicalTrials.gov ID
- NCT07787143
- Acronym / sponsor ID
- BMO-MTP / E-2406515-169
- Conditions
- Low Bone Mineral Density, Muscle Oxygenation
- Keywords
- Military aviation, Low bone mineral density, Near-infrared spectroscopy, Muscle oxygenation, Resistance training
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- Emine Merve ErseverUniversity, hospital or other
- Study start
- 15 Sep 2026 (estimated)
- Primary completion
- 15 Dec 2026 (estimated)
- Study completion
- 15 Feb 2027 (estimated)
- First posted
- 26 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, single-group interventional pilot study will evaluate the effects of a 12-week resistance and core stabilization exercise program on bone mineral density and resting muscle oxygenation in male military test pilots with low baseline bone mineral density. Participants will complete a supervised exercise program five days per week for 12 weeks while continuing their routine flight duties. Bone mineral density will be assessed using dual-energy X-ray absorptiometry, and resting muscle oxygenation will be evaluated in the vastus lateralis and rectus abdominis using near-infrared spectroscopy before and after the intervention. The study aims to characterize preliminary skeletal and muscle oxygenation responses to structured exercise in this specialized aviation population.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- All participants will receive the same 12-week supervised resistance and core stabilization exercise program. Outcomes will be assessed before and after the intervention, with no parallel control or comparison group.
| Arm | Type | Receives |
|---|---|---|
| Resistance and Core Stabilization Exercise Program | Experimental | Behavioral: Supervised Resistance and Core Stabilization Exercise ProgramParticipants will complete a 12-week supervised resistance and core stabilization exercise program, performed five days per week for approximately 120 minutes per session. The program will progress through three phases: adaptation (weeks 1-4, approximately 60% of one-repetition maximum), strength development (weeks 5-8, 70-75% of one-repetition maximum), and high-load neuromuscular control (weeks 9-12, 80-85% of one-repetition maximum). The intervention will include multi-joint lower-extremity exercises such as squats and deadlifts, core stabilization exercises including planks, side planks, bird-dog, dead bug, and posterior pelvic tilt, and posterior-chain exercises such as lunges, hip thrusts, and back extensions. All sessions will be supervised by a physiotherapist, and training loads will be adjusted according to participant performance and tolerance |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Male military test pilots with previous military aviation experience Low bone mineral density identified by dual-energy X-ray absorptiometry (DXA) Regular participation in flight duties Medical fitness to participate in regular exercise training Willingness to participate in the 12-week supervised resistance and core stabilization exercise program Ability to provide written informed consent
Key exclusion criteria (1 listed)
- Acute musculoskeletal injury Recent orthopedic surgery Neurological disorder Cardiovascular disease Any medical condition that limits participation in physical exercise Subcutaneous adipose tissue thickness greater than 17.5 mm at the NIRS measurement site
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Supervised Resistance and Core Stabilization Exercise ProgramParticipants will undergo a 12-week physiotherapist-supervised resistance and core stabilization exercise program performed five days per week for approximately 120 minutes per session. The program will progress through three phases: adaptation (weeks 1-4, approximately 60% of one-repetition maximum [1RM]), strength development (weeks 5-8, 70-75% 1RM), and high-load neuromuscular control (weeks 9-12, 80-85% 1RM). The intervention will include multi-joint lower-extremity exercises (squat and deadlift), core stabilization exercises (plank, side plank, bird-dog, dead bug, and posterior pelvic tilt), and posterior-chain exercises (lunges, hip thrusts, and back extensions). Exercise tempo and rest intervals will be standardized, and training loads will be individually adjusted according to participant performance and tolerance | Behavioural | Resistance and Core Stabilization Exercise Program |
Primary outcome
Change in Bone Mineral Density
Time frame: Baseline and 12 weeks
BMD will be assessed by DXA at lumbar spine and proximal femoral sites and recorded in g/cm². Change from baseline to 12 weeks will be evaluated. Time Frame: Baseline and 12 weeks
Change in Resting Muscle Oxygen Saturation (SmO₂)
Time frame: Baseline and 12 weeks
Resting muscle oxygen saturation will be measured using NIRS in the vastus lateralis and rectus abdominis and reported as percentage (%). Change from baseline to 12 weeks will be evaluated.
Change in Total Haemoglobin (tHb)
Time frame: Baseline and 12 weeks
Resting total haemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Change in Oxyhaemoglobin (O₂Hb)
Time frame: Baseline and 12 weeks
Resting oxyhaemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Change in Deoxyhaemoglobin (HHb)
Time frame: Baseline and 12 weeks
Resting deoxyhaemoglobin concentration will be measured using NIRS in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Change in Haemoglobin Difference (HbDiff)
Time frame: Baseline and 12 weeks
Resting haemoglobin difference will be derived from NIRS measurements in the vastus lateralis and rectus abdominis and reported in μM. Change from baseline to 12 weeks will be evaluated.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Aug 2026.
- Background: PubMed 36101451Tuesta M, Yanez-Sepulveda R, Verdugo-Marchese H, Mateluna C, Alvear-Ordenes I. Near-Infrared Spectroscopy Used to Assess Physiological Muscle Adaptations in Exercise Clinical Trials: A Systematic Review. Biology (Basel). 2022 Jul 19;11(7):1073. doi: 10.3390/biology11071073.
- Background: PubMed 30422769Marshall RA, Mandell JC, Weaver MJ, Ferrone M, Sodickson A, Khurana B. Imaging Features and Management of Stress, Atypical, and Pathologic Fractures. Radiographics. 2018 Nov-Dec;38(7):2173-2192. doi: 10.1148/rg.2018180073.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No
Related trials for Low Bone Mineral Density
Not yet recruitingPhase 2
Melatonin in Posterior Mandible Extraction Socket
Bone Loss
Active, not recruitingObservational study
CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis
Cystic Fibrosis, Bone Loss
Active, not recruiting
AI-Supported Mobile High-Impact and Strengthening Exercise Program in Postmenopausal Women With Low Bone Density
Osteopenia
Active, not recruiting
L-PRF Block vs Composite Graft for Horizontal Ridge Augmentation
Alveolar Ridge Resorption After Extraction, Alveolar Bone Loss
RecruitingObservational study
Observational Study of Bone Complications in People With Post-menopausal Breast Cancer Who Have Stopped Treatment With Denosumab and Aromatase Inhibitors
Breast Cancer
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Supervised Resistance and Core Stabilization Exercise Program in people with Low Bone Mineral Density and Muscle Oxygenation, run by Emine Merve Ersever.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Emine Merve ERSEVER, DR (0905074515481, emersever@ankara.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Bone Mineral Density (time frame: Baseline and 12 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07787143, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Aug 2026.