Clinical trials: Biological Maturation
Digestive Cancer, Gynecologic Cancer
Development of Clinical and Biological Database
The BCB is a tool: for research in analytical and public health epidemiology, biological research and for the development of data useful for clinical research and therapeutic trials; to help scientists understand and explain…
- Conditions
- Digestive Cancer, Gynecologic Cancer, Breast Cancer, Sarcoma
- Trial name
- BCBInstitut (NCT03449264)
- Testing
- biological collection
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Laboratory Procedure Development and Validation
Specimen Collection Study for Development and Validation of Laboratory Procedures
Biologic samples are necessary for development and validation of laboratory procedures (e.g. novel biological and analytical assays, explant tissue models, validation of specimen collection and transport) to support future…
- Trial name
- NCT01236027
- Testing
- no intervention
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
Development of a Cinical and Biological Database in Ovarian, Fallopian Tube and Peritoneal Cancers
A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical datas to improve knowledge about cancer and help to develope new cancer treatments.
- Conditions
- Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Peritoneal Neoplasms
- Trial name
- BCBOvaire (NCT03976999)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Infectious Disease, Tropical Disease
Collection of Human Biological Samples for the Development and Validation of New Methods of Diagnosis and for the Realization of Expertises Diagnostics in the Field of Infectious Diseases and Tropical
Direct constitution of collections from various samples taken on a prospective cohort of healthy volunteers, to prepare human biological samples of known characteristics (biochemical and serological in particular) and quality…
- Trial name
- Diagmicoll (NCT03912246)
- Testing
- biological samples, lumbar puncture
- Where
- 2 sites in France
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Autism Spectrum Disorder
Cerebellar tDCS in Children With Autism Spectrum Disorder
The purpose of this research study is to investigate whether tDCS to the cerebellum (specifically, the right crus I/II area of the cerebellum) of children and young adults with autism spectrum disorders (ASD) is safe and to…
- Trial name
- NCT04446442
- Testing
- tDCS
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Anterior Cruciate Ligament Rupture, Donor Site Complication
BTB Graft Harvest and Donor Site Morbidity After ACL Reconstruction
The aim of this observational study is to examine the connection between bone-tendinous defects after BTB graft harvest and the development of anterior knee pain.
- Trial name
- NCT06030791
- Testing
- MRI
- Where
- Serbia
- Volunteers
- 60 people
- Sponsor
- Clinical Center of Vojvodina
Autism Spectrum Disorder
Fatty Acid Supplementation in Children With ASD
The purpose of this study is to examine how fatty acid supplementation alters biological signatures in children with ASD
- Trial name
- Omega Heroes (NCT03550209)
- Testing
- LCPUFA Oil Supplement
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Sarah Keim
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors
Population ageing is one of the main factors responsible for the global increase in the prevalence of dementia. Recent evidence suggests that modifiable risk factors, such as cardiovascular disease and lifestyle, may increase the…
- Trial name
- PrevAl (NCT07731191)
- Testing
- Digital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Biological Maturation
Biological Maturation and Plyometric Exercise
Plyometric training comprises one of the most widely used training methods in both individual and team sports, and is widely used by coaches as one of the main training in both adults, and children.
- Trial name
- BiMaPlEx (NCT05442593)
- Testing
- Plyometric training
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Schizophrenia, Autism Spectrum Disorder
Biological Implications of the Overlapping Phenomenon Between Childhood Schizophrenia and Autism Spectrum Disorders-Heterogeneity Approach Rather Than Diagnostic Boundary
Complex diseases such as schizophrenia and autism are heterogeneous in clinical presentation and etiology. This high heterogeneity constitutes the challenges for the clinical diagnosis and etiological research, resulting in that…
- Trial name
- NCT06063525
- Testing
- Structural anatomy
- Volunteers
- 230 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorders
Developmental Trajectories in ASD Until Adulthood: A 15 Years Follow-up Study
Epidemiological studies have shown that a wide range of outcome trajectories exist in ASD, but little is known about their determinant in a long-term perspective.
- Trial name
- EpiTED (NCT02828332)
- Testing
- Vineland II (VABS -II), Quality of life
- Volunteers
- 106 people
- Sponsor
- University Hospital, Montpellier
Cancer, Peritoneal Carcinosis
Development of a Clinical and Biological Database in Peritoneal Carcinosis (BCB CARCINOSE)
The creation of a prospective clinical-biological base dedicated to peritoneal carcinosis must therefore be able to serve as a support for this essential search for transfer.
- Trial name
- BCB (NCT04221464)
- Testing
- biological collection, Tissues collections
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Autism Spectrum Disorder
The Validation and Biological Index Studies on the Improved Social Function of ASD by 40 Hz tACS
In this proposed study, tACS will be used to intervene in the autism spectrum disorders of children and adolescents, and the efficacy of this intervention method will be evaluated, as well as the internal mechanism of…
- Trial name
- NCT06362200
- Testing
- 40 Hz tACS intervention
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Central South University
Vasculopathy, Heart Transplant Failure
The Role of CD34 + Stem Cells and Biomarkers in the Development of CAV in HTX Patients
Coronary allograft vasculopathy represents one of the major limiting factors of long-term survival in heart transplant recipients.
- Trial name
- NCT05485467
- Testing
- coronary CT angiography
- Where
- Slovenia
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Healthy, Malaria
A Phase I Clinical Trial Immunizing Healthy Adults With the NMRC-M3V-Ad-PfCA Vaccine to Generate Biologic Reagents
This is an open label Phase 1 study of the Ad-PfCA vaccine designed to 1) provide reagents for the development and refinement of cell-mediated immunoassays for measuring the human immune response to candidate malaria vaccines…
- Trial name
- AdBa (NCT01843491)
- Testing
- Ad-PfCA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Smoking Cessation, Smoking Cessation Intervention
Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies
This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets.
- Conditions
- Smoking Cessation, Smoking Cessation Intervention, Nicotine Addiction, Epigenetics
- Trial name
- NicoGen (NCT06471387)
- Testing
- Flexiquit Smoking Cessation Intervention
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Acute Kidney Injury
Development of an Innovative Clinico-biological Score for the Early Detection of Acute Renal Failure Associated With Cardiac Surgery.
The prediction and early detection of acute renal failure associated with cardiac surgery (ARF-CS) are desirable in order to try to reduce its magnitude.
- Trial name
- DETECT-AKI (NCT05283213)
- Testing
- Early biomarkers of acute kidney injury
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
Rubinstein-Taybi Syndrome
Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic Trial
An exploratory phase 2 therapeutic trial in children from 6 to 21, RTS carriers, randomized to be treated either with sodium valproate with the usual pediatric dosage (30 mg/kg/j), or by placebo for one year.
- Trial name
- RUBIVAL (NCT01619644)
- Testing
- sodium valproate
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Bordeaux
Coronavirus Infections, Vaccine
Observational Program, Study the Preventive Efficacy of the BiVac Polio Vaccine Against the Incidence of Acute Respiratory Infections, Including COVID-19
Observational program, double-blind, placebo-controlled to study the preventive efficacy of the BiVac polio (Oral polio vaccine, divalent, live attenuated of types 1 and 3 vaccine against the incidence of acute respiratory…
- Conditions
- Coronavirus Infections, Vaccine, Polio
- Trial name
- NCT05083039
- Where
- Russia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products