Clinical trials: Benzodiazepines
Benzodiazepine Withdrawal
Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users
We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients.
- Trial name
- BENZ_HALTE (NCT06446349)
- Testing
- Brief motivational intervention
- Where
- 20 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Grenoble
Anxiety, Insomnia
Augmenting Benzodiazepine Receptor Agonist Deprescribing With Acupuncture and Yoga Among Older Adults
The main purpose of this 12-week study is to see if a new combination of treatments can help older adults reduce benzodiazepine or related medication use.
- Conditions
- Anxiety, Insomnia, Benzodiazepine, Deprescription
- Trial name
- NCT06197243
- Testing
- Acupuncture, Yoga, Deprescribing
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Benzodiazepine Dependence
Effects of Intranasal Oxytocin in the Treatment of Benzodiazepine Withdrawal: A Pilot RCT
The goal of this clinical trial is to learn if oxytocin administered as a nasal spray will reduce withdrawal symptoms in adults during benzodiazepine tapering for 21 days. It will also learn about the safety of oxytocin.
- Trial name
- NCT06757517
- Testing
- Oxytocin nasal spray
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- St. Olavs Hospital
Benzodiazepines Deprescribing, Sleep Problems
Improving Patient Safety by Supporting Older Adults in Managing Sleep Problems.
Among older adults (≥65 years), use of sleeping pills, such as benzodiazepines and other sedative-hypnotics, to treat sleep problems is common.
- Trial name
- BE-SAFE (NCT06584513)
- Testing
- Specific tapering plan for sleep medication, educational and cognitive behavioural therapy elements
- Where
- 6 sites in Belgium, Greece and 4 more
- Volunteers
- 470 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Primary Care, Health Plan Implementation
Effectiveness of a Joint General Practitioner-Pharmacist Intervention on Benzodiazepine Deprescribing in the Elderly
Benzodiazepines or related drug (BZDR) are consumed for hypnotic or anxiolytic purposes in most cases. The consequences of BZDR are multiple with an increased risk of daytime sedation, balance disorders leading to falls and…
- Conditions
- Primary Care, Health Plan Implementation, Benzodiazepine Dependence, Elderly
- Trial name
- BESTOPH-MG (NCT05765656)
- Testing
- GP - pharmacist collaboration and pharmacist motivational interviewing
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
Benzodiazepine Dependence
Baclofen for Improving Benzodiazepine Titration in Benzodiazepine Dependence
Benzodiazepines and related molecules are among the most prescribed psychotropic treatments in France and Europe. 13.4% of the French population had at least one reimbursement of benzodiazepines in 2015, which places France…
- Trial name
- BABET (NCT05935553)
- Testing
- Baclofen 30 mg, Baclofen 60 mg
- Where
- 2 sites in France
- Volunteers
- 93 people
- Sponsor
- Hospices Civils de Lyon
Benzodiazepine Use, Insomnia
Brief Cognitive Behavioral Therapy to Enhance Benzodiazepine Deprescribing
The goal of this clinical trial is to conduct a single-arm pilot trial of a brief cognitive-behavioral therapy-enhanced benzodiazepine deprescribing intervention in 20 older adults (aged ≥55 years) prescribed chronic…
- Conditions
- Benzodiazepine Use, Insomnia, Anxiety
- Trial name
- NCT06119308
- Testing
- Benzodiazepine Medication Taper with Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Beth Israel Deaconess Medical Center
Benzodiazepine Use
Evaluation of a Clinical Support Website for the Management of Common Mental Health Conditions in Primary Care on Compliance With Benzodiazepine Prescribing Recommendations
This cluster-randomized study aims to evaluate the impact of a web-based clinical support tool on adherence to recommended maximum durations for benzodiazepine prescriptions among new users in primary care.
- Trial name
- Psycho-MG (NCT07379073)
- Testing
- Training
- Volunteers
- 100 people
- Sponsor
- MSPU de Pins-Justaret
Taking Benzodiazepines for Any Reason for 3 Months, Benzodiazepine Dependence
Promoting Benzodiazepine Cessation Through an Electronically-delivered Patient Self-management Intervention
Benzodiazepines (e.g., Ativan, Xanax) are widely prescribed medications that are used mainly to treat anxiety and sleeping difficulties.
- Trial name
- EMPOWER-ED (NCT04572750)
- Testing
- EMPOWER-ED
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Opioid Abuse, Benzodiazepine Abuse
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
In this study, the investigators will measure affective, neurocognitive and behavioral outcomes related to chronic use of opioids and benzodiazepines (screening phase), and in response to the administration of the opioid…
- Conditions
- Opioid Abuse, Benzodiazepine Abuse, Polysubstance Abuse
- Trial name
- MAP (NCT05006079)
- Testing
- Morphine, Alprazolam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wayne State University
Benzodiazepine Dependence, Anxiety Disorders
Anxiety Lowering and Deprescribing Through Emotion Regulation
The goal of this clinical trial is to test ALDER (Anxiety Lowering and Deprescribing through Emotion Regulation), an online self-guided positive emotion intervention, in patients over the age of 65 who are candidates for…
- Conditions
- Benzodiazepine Dependence, Anxiety Disorders, Sleep Disturbance
- Trial name
- ALDER (NCT06359314)
- Testing
- ALDER
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Delirium, Critical Illness
Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery
"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care.
- Conditions
- Delirium, Critical Illness, Aged, Cardiopulmonary Bypass
- Trial name
- NCT07265128
- Testing
- Midazolam, Remimazolam
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Benzodiazepines, Bladder Cancer
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer.
- Conditions
- Benzodiazepines, Bladder Cancer, Delirium, Surgery
- Trial name
- NCT04532606
- Testing
- Remimazolam, Propofol
- Where
- 6 sites in China
- Volunteers
- 1,128 people
- Sponsor
- Peking University First Hospital
Benzodiazepine-Related Disorders
Informative Exhibition for Deprescribing Benzodiazepines
The goal of this trial is to determine if an interactive and informative exhibition in the waiting room of a Primary Care Clinic can reduce the use of benzodiazepines in adults.
- Trial name
- ESUB (NCT06467019)
- Testing
- Informative Session
- Where
- Spain
- Volunteers
- 6,410 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Aging, Benzodiazepine Sedative Adverse Reaction
NUDGE-EHR Replication Trial at Mass General Brigham
Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable…
- Conditions
- Aging, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction, Adverse Drug Event
- Trial name
- NUDGE-EHR (NCT05538065)
- Testing
- Follow-up booster Alert, Pre-commitment, Enhanced Alert
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Brigham and Women's Hospital
Benzodiazepine Adverse Reaction, Depression, Anxiety
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers.
- Conditions
- Benzodiazepine Adverse Reaction, Depression, Anxiety, Benzodiazepine Dependence
- Trial name
- NCT06250842
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Deprescription, Benzodiazepine (BZD) and Related Drugs
Multimodal Educative Data Feedback for Deprescribing BZD and Related Drugs in Outpatients: a Cluster RCT
Benzodiazepine (BZD) and related drugs are sedative anxiolytics and hypnotics that should be avoided especially in people aged 65 years and older, given the high risk of falling, fracture, dependence, respiratory depression and…
- Trial name
- NCT05859555
- Testing
- Thematic quality circles - Deprescription
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Réseau de soins Delta
Aging, Benzodiazepine Sedative Adverse Reaction
Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable…
- Conditions
- Aging, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction, Adverse Drug Event
- Trial name
- NUDGE-EHR (NCT04284553)
- Testing
- Order Entry, Open Encounter, Follow-up booster Alert
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Brigham and Women's Hospital
Benzodiazepine Withdrawal
Can Connected Devices Increase the Success Rate of Benzodiazepine Withdrawals in the Elderly?
This is a prospective randomized open study, which aims to evaluate the benefit of a connected watch to help people aged 65 years and older to withdraw from BZD over a six-month period, compared with classical withdrawal (e.g…
- Trial name
- BENZO-E-STOP (NCT04912479)
- Testing
- connected watch
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Benzodiazepine
Effect of Remimazolam Use During Perioperative Period on Brain Waves and Postoperative Cognitive Function
Benzodiazepine sedative hypnotics are commonly used intravenous anesthetics in clinical practice. Remimazolam is a new benzodiazepine with the characteristics of rapid onset, short maintenance and recovery time, no accumulation…
- Trial name
- NCT04601350
- Testing
- remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia, control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Yangzhou University