Clinical trials: Augmented Renal Clearance
Hemorrhagic Stroke, Augmented Renal Clearance
ARC in Hemorrhagic Stroke
To determine the incidence and predictors of augmented renal clearance (ARC) in patients with hemorrhagic stroke.
- Trial name
- NCT02386202
- Testing
- No intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
PCOS
Insulin and Polycystic Ovary Syndrome
Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women.
- Trial name
- NCT00683774
- Testing
- diazoxide
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Augmented Renal Clearance, Critically Ill
Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance
Evaluation of glomerular filtration rate using iohexol plasma clearance in critically ill patients with augmented renal creatinine clearance
- Trial name
- GFR-ARC (NCT04776486)
- Testing
- Iohexol
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Augmented Renal Clearance, Critical Illness
Fluorescent Probe for Assessment of Renal Elimination
Accurate measures of kidney function is important for precision dosing of many medications. The current methods of determining kidney function largely hinge on the use of equations that use common laboratory values such as serum…
- Trial name
- FLARE (NCT07643467)
- Testing
- Relmapirazin, Iohexol, Medibeacon tGFR monitor
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Aaron Cook
Critical Illness, Augmented Renal Clearance
Detailed Assessment of Augmented Renal Clearance in a Large Mixed Intensive Care Unit Population
This multi-center retrospective cohort study presents a detailed assessment of augmented renal clearance (ARC) in a mixed population of adult critically ill patients.
- Trial name
- NCT03954275
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 10,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Early Ventilator Associated Pneumonia, Acute Brain Injuries
PK/PD Target Attainment of Ceftriaxone for the Prevention of Early Ventilator-associated Pneumonia in Neurologically Injured Patients
Critically ill patients admitted for acute brain injury are exposed to many heath-care associated infections such as ventilator associated pneumoniae (VAP).
- Trial name
- NeuroPKVAP (NCT07450404)
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis
Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance
Critically ill patients with sepsis undergo several physiological alterations that can alter the distribution, metabolism, and elimination of drugs.
- Trial name
- NCT04147221
- Testing
- Imipenem-relebactam
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Hartford Hospital
Polycystic Ovary Syndrome
Effects of Pioglitazone on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome (PCOS)
Our hypothesis is that hyperinsulinemia increases the renal clearance of D-chiro-inositol (DCI) in women with polycystic ovary syndrome (PCOS) and that this leads to a reduction in circulating insulin-stimulated…
- Trial name
- PCOS (NCT00868140)
- Testing
- pioglitazone
- Where
- 2 sites in United States, Venezuela
- Volunteers
- 51 people
- Sponsor
- Virginia Commonwealth University
Augmented Renal Clearance, Critical Illness
Incidence and Associated Risk Factors of ARC in the Trauma Critically Ill Older Than 50 Years Old
This single-center prospective cohort study conducted at the adult trauma ICU of the Montreal General Hospital (MGH) affiliated with the McGill University Health Centre (MUHC) aims to determine the incidence and associated risk…
- Conditions
- Augmented Renal Clearance, Critical Illness, Polytrauma, Traumatic Brain Injury
- Trial name
- NCT04766944
- Testing
- No intervention
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Critical Illness, Pharmacokinetics
Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis
WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine \& ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset
- Trial name
- NCT03560557
- Volunteers
- 116 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Subarachnoid Hemorrhage, Aneurysmal
Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With External Ventricular Drainage
The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs).
- Trial name
- NCT06119061
- Testing
- Telavancin Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Aaron Cook
Pneumonia
Population Pharmacokinetic (PK) Study of Zinforo (Ceftaroline) in Critical Care Patients With Early-onset Pneumonia and Normal or Augmented Renal Clearance
Pneumonia is the most frequent infection in critically ill patients and remains a significant challenge to intensivists world-wide due to persisting high mortality and morbidity.
- Trial name
- CEFTAREA (NCT03025841)
- Testing
- Ceftaroline
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Poitiers University Hospital
Bacterial Meningitis, Augmented Renal Clearance
Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance
The investigator's purpose is to study the population pharmacokinetics of commonly used antimicrobial agents in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility.
- Trial name
- NCT04771884
- Testing
- meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Augmented Renal Clearance (ARC), Systemic Inflammatory Response Syndrome (SIRS)
Pharmacokinetic Study of Ceftaroline Fosamil/Avibactam in Adults With Augmented Renal Clearance
To evaluate the pharmacokinetic (PK) profiles of ceftaroline and avibactam in adults with augmented renal clearance (ARC).
- Trial name
- NCT01624246
- Testing
- Ceftaroline fosamil/Avibactam (CXL)
- Where
- 21 sites in United States, Australia
- Volunteers
- 12 people
- Sponsor
- Forest Laboratories
Drug Clearance After Severe Burn Injury
Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries
Cefiderocol is a powerful, broad spectrum antibiotic approved to treat hospital-acquired or ventilator associated pneumonia and urinary tract infections.
- Trial name
- NCT07465432
- Testing
- Cefiderocol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Tennessee
Subarachnoid Hemorrhage
Effects of Augmented Renal Clearance on Pharmacokinetic and Pharmacodynamic Properties of Levetiracetam in Subarachnoid Hemorrhage
This study evaluates the pharmacokinetic profile of levetiracetam in critically ill patients who have suffered a subarachnoid hemorrhage.
- Trial name
- NCT02866877
- Testing
- Pharmacokinetic modeling
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Surgery
Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients (TAPAS)
In this prospective observational study, the investigators want to document pharmacokinetic/pharmacodynamic (PK/PD) target attainment of frequently used antimicrobials in an adult non critically ill surgery population (abdominal…
- Trial name
- TAPAS (NCT03120663)
- Testing
- amoxicillin-clavulanic acid
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Febrile Neutropenia
Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance
This clinical trial focuses on children with cancer who face infections after receiving chemotherapy. Chemotherapy affects the bone marrow, leading to a decrease in the production of certain white blood cells, particularly those…
- Trial name
- DAR-ARC (NCT06293677)
- Testing
- Dosage Adjustment Rules for Augmented Renal Clearance (DAR-ARC) for piperacillin-tazobactam and meropenem, Standard dosages of piperacillin-tazobactam or meropenem
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Prevalence of Augmented Renal Clearance, Risk Factors for Augmented Renal Clearance
Augmented Renal Clearance in the Adult Non-critically Ill Surgery Patient: a Prospective Point Prevalance Study
This point prevalence study investigates the prevalence of augmented renal clearance (i.e. a measured 8-hour urinary creatinine clearance >= 120 ml/min/1.73m²) in an adult non-critically ill abdominal and trauma surgery…
- Trial name
- ARCPPS (NCT02228551)
- Testing
- Augmented renal clearance Point prevalence study
- Where
- Belgium
- Volunteers
- 279 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven