Clinical trials: Atrial Fibrillation (AF), open to volunteers
Atrial Fibrillation, Persistent Atrial Fibrillation
Feasibility Study of the FARAFLEX Mapping and PFA System
The objective of this feasibility study is to evaluate the safety and effectiveness of the FARAFLEX mapping and pulsed field ablation (PFA) catheter, a novel catheter in treating persistent atrial fibrillation (PersAF) or…
- Conditions
- Atrial Fibrillation, Persistent Atrial Fibrillation, Paroxysmal AF
- Trial name
- ELEVATE-PF (NCT06510556)
- Testing
- FARAFLEX Ablation Treatment, ELEVATE-COR Sub-study
- Where
- 4 sites in Belgium, Croatia and 2 more
- Volunteers
- 250 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF), Paroxysmal AF
Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
The objective of this clinical investigation is to evaluate the feasibility, safety, and effectiveness of a concomitant procedure involving the Volt PFA System and Amulet 2 device in patients indicated for both AF ablation and…
- Conditions
- Atrial Fibrillation (AF), Paroxysmal AF, Persistent Atrial Fibrillation
- Trial name
- CLEAR (NCT07523620)
- Testing
- PVI Ablation, Left Atrial Appendage Occluder Implant
- Where
- 16 sites in Belgium, Czechia and 8 more
- Volunteers
- 240 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF)
A Global Randomized Trial Evaluating the FARAFLEX™ Mapping and Pulsed Field Ablation System With Electrographic Flow Mapping in Patients Undergoing Repeat Ablation for Atrial Fibrillation
The goal of the ReDEFINE-AF Clinical Study is to evaluate the safety and effectiveness of the FARAFLEX™ Mapping and Pulsed Field Ablation System with electrographic flow mapping in subjects undergoing repeat ablation for atrial…
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation (PersAF), Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- ReDEFINE-AF (NCT07820930)
- Testing
- FARAFLEX Mapping and Pulsed Field Ablation System
- Volunteers
- 650 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA)
Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation
Post-operative atrial fibrillation (POAF) is a frequent complication of surgical aortic valve replacement, affecting 38 to 63% of patients, and increasing risks of stroke, heart failure, and long-term mortality.
- Conditions
- Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA), Heart Failure, Myocardial Infarction (MI)
- Trial name
- VAGASTIMA-PILT (NCT07891390)
- Testing
- tVNS session on the left earlobe
- Where
- 3 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Failure, Coronary Heart Disease (CHD)
Reliability of Multiple-Repetition-Maximum Tests in Patients With Cardiovascular Disease or Risk Factors
Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important.
- Conditions
- Heart Failure, Coronary Heart Disease (CHD), Atrial Fibrillation (AF), Diabetes Mellitus
- Trial name
- NCT06796582
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Atrial Fibrillation (AF)
Assessment of Catheter Tissue Contact in PFA
Pulmonary vein isolation remains the cornerstone of invasive treatment for atrial fibrlllation. Despite recent technological advances in the field of pulsed field ablation (PFA) pulmonary vein isolation durability and arrhythmia…
- Trial name
- ASSESS PFA (NCT07721948)
- Testing
- Electrode tissue contact assessment during pulsed field ablation
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation (AF)
Efficacy and Safety of Individualized Pulsed Field Ablation Guided by Pulmonary Vein Antral Substrate Mapping for Atrial Fibrillation
This study will adopt a prospective, single-center, single-arm research design, enrolling 120 patients with paroxysmal or persistent atrial fibrillation who are scheduled to undergo catheter ablation for the first time.
- Trial name
- NCT07880262
- Testing
- Individualized Pulsed Field Ablation Guided by Pulmonary Vein Antral Substrate Mapping
- Volunteers
- 120 people
- Sponsor
- Xi'an Jiaotong University
Atrial Fibrillation (AF), Atrial Tachycardia
Conduction Breakthrough in the Coronary Sinus Post Endocardial Mitral Isthmus Ablation
The goal of this observational study is to learn more about how doctors can create a complete electrical block in the heart during catheter ablation procedures used to treat certain abnormal heart rhythms.
- Conditions
- Atrial Fibrillation (AF), Atrial Tachycardia, Paroxysmal AF, Persisent Atrial Fibrillation
- Trial name
- COSMIC (NCT07889440)
- Volunteers
- 50 people
- Sponsor
- Sebastien Knecht
Atrial Fibrillation (AF)
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly.
- Trial name
- ROXI-ATLAS (NCT07175428)
- Testing
- REGN7508, REGN9933, Apixaban
- Where
- 89 sites in United States, Argentina and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Regeneron Pharmaceuticals
Atrial Fibrillation (AF), Coronary Artery Disease
Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation
The goal of this clinical trial is to learn whether the antiarrhythmic drug flecainide can be used as safely as standard rhythm-control drugs in people with atrial fibrillation (AF) and stable coronary artery disease (CAD).
- Trial name
- ReCAST AF (NCT07405671)
- Testing
- flecainide, Sotalol or Amiodarone
- Where
- 14 sites in Belgium
- Volunteers
- 988 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atrial Fibrillation (AF)
Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy.
The goal of this clinical trial is to learn if a bundle of three treatments can prevent atrial fibrillation, a heart rhythm disorder often observed in adults following heart surgery.
- Trial name
- PREV-AF (NCT07887022)
- Testing
- Colchicine, Amiodarone, Posterior pericardiotomy
- Where
- 3 sites in France
- Volunteers
- 636 people
- Sponsor
- Elsan
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction
Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
This study is testing two different ways of treating atrial fibrillation (AF) in people who also have heart failure with mildly reduced or preserved heart function.
- Conditions
- Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction (HFPEF), Rate Control
- Trial name
- NCT07272902
- Testing
- Catheter Ablation for Atrial Fibrillation, Rate Control Medications (beta-blockers, calcium channel blockers, digoxin)
- Where
- 4 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Nova Scotia Health Authority
Atrial Fibrillation (AF)
Sex-Based Disparities in the Electrophysiological Substrate for Atrial Fibrillation and Its Impact on Clinical Outcomes
DISPARITY-AF is a prospective, single-center, observational registry designed to characterize the sex-based disparities in the electrophysiological substrate driving Atrial Fibrillation (AF).
- Trial name
- NCT07580547
- Testing
- Identifying extra-PV SRG sites
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Anat Milman
Intracerebral Hemorrhage, Atrial Fibrillation (AF)
Oral Anticoagulation in Patients With Prior Deep Intracerebral Hemorrhage, Atrial Fibrillation, and Ischemic Stroke
This prospective, multicenter, randomized, open-label, blinded-endpoint trial aims to evaluate the efficacy and safety of oral anticoagulation with apixaban in patients with non-valvular atrial fibrillation, ischemic stroke, and…
- Conditions
- Intracerebral Hemorrhage, Atrial Fibrillation (AF), Ischemia Stroke
- Trial name
- OASIS-AF (NCT07609654)
- Testing
- Apixaban, No Oral Anticoagulation Strategy
- Where
- China
- Volunteers
- 852 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation (AF)
BOdygUardian MOnitoriNg for ReCurrencE of AF
The DISRUPT-AF Registry is an observational, prospective, multi-center, non-randomized, real-world registry designed to obtain clinical experience with the FARAPULSE Pulsed Field Ablation (PFA) System for the treatment of atrial…
- Trial name
- BOUNCE-AF (NCT07671677)
- Testing
- BodyGuardian
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Heart Rhythm Clinical and Research Solutions, LLC
AF - Atrial Fibrillation
Comparison of Two Pulse Field Ablation Systems for AF Ablation
This study randomizes patients undergoing PFA for A Fib to one of two standard care PFA systems. The patient will have an ICM placed to continuously monitor their heart rhythm.
- Trial name
- COBRA (NCT07883629)
- Testing
- Pulse Field Ablation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Atrial Fibrillation (AF)
Energy Dose and Cardioversion Outcomes in AF
This multicenter, randomized study will compare two electrical cardioversion energy strategies in adults with atrial fibrillation who are scheduled to undergo cardioversion during atrial fibrillation ablation or within 3 months…
- Trial name
- LE-HI-CV (NCT07884253)
- Testing
- Synchronized Electrical Cardioversion With Different Energy Strategies, Conventional Step-Up Energy Cardioversion
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation (AF), Persistent Atrial Fibrillation
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Conquer-AF is a prospective, multi-center, interventional, non-randomized clinical study that will enroll up to 400 subjects at up to 30 sites across the United States, Europe, and Australia.
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Conquer-AF (NCT07298473)
- Testing
- Sphere-9 Catheter Ablation
- Where
- 30 sites in United States, Australia and 4 more
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation (AF), Atrial Flutter
Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in Japan
The goal of this clinical trial is to compare the yield of clinically actionable arrhythmias through the end of indicated wear duration in Zio monitor and Heartnote patch ECG devices.
- Conditions
- Atrial Fibrillation (AF), Atrial Flutter, Supraventricular Tachycardia (SVT), Ventricular Tachycardia (VT)
- Trial name
- Japan H2H (NCT07870837)
- Testing
- Application of ambulatory cardiac monitor
- Where
- 4 sites in Japan
- Volunteers
- 130 people
- Sponsor
- iRhythm Technologies, Inc.
Ulcerative Colitis, Myocardial Infarction
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI)
Inflammatory bowel diseases (IBD) are progressively increasing their prevalence worldwide. Up to half of patients may also have extraintestinal manifestation and cardiovascular diseases (CVDs) is one of the most relevant, being…
- Conditions
- Ulcerative Colitis, Myocardial Infarction, Stroke, Ischemic Heart Disease
- Trial name
- PROVACI (NCT07095634)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato