Clinical trials: Atrial Fibrillation (AF)
Persistent Atrial Fibrillation
Cryoballon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation
A randomized trial has recently demonstrated non-inferiority of cryoballoon vs. radiofrequency (RF) catheter ablation in patients with drug-refractory paroxysmal atrial fibrillation (AF).
- Trial name
- IRON-ICE (NCT03365700)
- Testing
- Radiofrequency Ablation, Cryoballoon ablation
- Where
- 3 sites in Italy
- Volunteers
- 303 people
- Sponsor
- Luigi Sacco University Hospital
Atrial Fibrillation
Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF
The study is a prospective, multi-center, non-randomized, unblinded worldwide pre-market clinical study. The purpose of the study is to provide data demonstrating the safety and effectiveness of the PulseSelect™ PFA System for…
- Trial name
- PULSED AF (NCT04198701)
- Testing
- Medtronic PulseSelect Pulsed Field Ablation (PFA) System
- Where
- 41 sites in United States, Australia and 7 more
- Volunteers
- 421 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation, Arrhythmias, Cardiac
Accuracy of LAA Occluder Size Selection: CT vs. DSA During Combined AF Ablation and LAA Occlusion
This study is a prospective, multi-center, randomized controlled trial. The subjects are patients scheduled to undergo a combined procedure of atrial fibrillation (AF) ablation and left atrial appendage (LAA) occlusion.
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT06455644
- Testing
- CT group, DSA group
- Where
- 5 sites in China
- Volunteers
- 238 people
- Sponsor
- First Affiliated Hospital of Shantou University Medical College
Atrial Fibrillation (AF)
Deep Sedation vs. General Anesthesia for Pulsed Field Ablation in Atrial Fibrillation
1. Research Title: A Study on the Safety and Efficacy of Deep Sedation With Dexmedetomidine Combined With Remimazolam and Remifentanil Versus General Anaesthesia for Radiofrequency Ablation of Atrial Fibrillation 2.
- Trial name
- SAFE-PFA (NCT07621432)
- Testing
- Standardized Deep Sedation Protocol, Standard General Anesthesia
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Atrial Fibrillation
Radiofrequency vs Cryoballoon Ablation for Atrial Fibrillation Assessed by Implantable Cardiac Monitor
The study is a prospective randomized comparison of two methods of catheter ablation of atrial fibrillation: Radiofrequency ablation which is the standard of care will be compared to Cryoballoon ablation to perform pulmonary vein…
- Trial name
- RACE-AF (NCT03805555)
- Testing
- Radiofrequency ablation, Cryoballoon ablation
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Iron-deficiency, Atrial Fibrillation
Prevalence and Clinical Associates of Iron Deficiency in Patients With Atrial Fibrillation
To estimate the prevalence of iron deficiency (ID) in patients with atrial fibrillation
- Trial name
- AID-AF (NCT03957187)
- Testing
- Ferritin, iron and iron binding capacity, high sensitive C-reactive protein (CRP) measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Koç University
Congestive Heart Failure, Atrial Fibrillation
Ventricular Rate Regularization for Improved Quality of Life in Patients With CHF and AF
Single center investigator initiated sponsored by Guidant Boston Scientific Corp. to evaluate the benefit of ventricular rate regularization (VRR) in patients with congestive heart failure (CHF) and significant atrial…
- Trial name
- VRR (NCT00583921)
- Sponsor
- University of California, Davis
Atrial Fibrillation
FLorida Puerto Rico Atrial Fibrillation Stroke Study (FLiPER-AF)
In this study, FL-PR Stroke Registry will be used to determine novel data on disparities in stroke care and outcomes for patients with Atrial Fibrillation (AF) in 'real life' hospital setting.
- Trial name
- FLiPER-AF (NCT03627806)
- Where
- United States
- Volunteers
- 104,308 people
- Sponsor
- University of Miami
Atrial Fibrillation (AF)
Electroporation Treatment for Early AF Management in Heart Failure With Preserved Ejection Fraction (HFpEF) Pilot Study
The proposed pilot study is a prospective, randomized, single-center feasibility study, enrolling 200 patients with symptomatic paroxysmal AF.
- Trial name
- E-TEAM (NCT07385417)
- Testing
- AF Ablation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
Atrial Fibrillation
AtriCure Bipolar Radiofrequency Ablation of Permanent Atrial Fibrillation
ABLATE is a prospective, non-randomized multi-center clinical trial to demonstrate the safety and effectiveness of the AtriCure Bipolar System for treating permanent atrial fibrillation during concomitant on-pump cardiac surgery.
- Trial name
- ABLATE (NCT00560885)
- Testing
- AtriCure Bipolar System
- Where
- 9 sites in United States
- Volunteers
- 55 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation (AF)
Noninvasive Mapping Before Surgical Ablation
The purpose of this study is to assess the electrophysiological mechanism of atrial fibrillation by means of a beat-to-beat noninvasive 3D mapping method in patients with concomitant persistent and long-standing persistent atrial…
- Trial name
- NIMSA (NCT06803615)
- Testing
- Electrocardiographic imaging
- Where
- Austria
- Volunteers
- 51 people
- Sponsor
- Medical University of Vienna
Atrial Fibrillation
Tailored Treatment of Permanent Atrial Fibrillation
The purpose of this trial is to evaluate the safety and efficacy of the Medtronic Cardiac Ablation System compared to medical therapy in the persistent and long-standing persistent atrial fibrillation population.
- Trial name
- TTOP-AF (NCT00514735)
- Testing
- Medtronic Cardiac Ablation System, Class I or III Antiarrhythmic Medications
- Where
- 24 sites in United States, Netherlands
- Volunteers
- 210 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Atrial Fibrillation
Concomitant Treatment of Permanent Atrial Fibrillation
RESTORE-SR study is a multi-center, prospective, nonrandomized study with case matched concurrent controls to evaluate the safety and efficacy of the AtriCure Bipolar System
- Trial name
- RESTORE SR (NCT00566787)
- Testing
- Surgical bipolar radiofrequency ablation using the AtriCure Bipolar System
- Where
- 10 sites in United States
- Volunteers
- 39 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Comparison of Anticoagulation With Left Atrial Appendage Closure After AF Ablation
The primary objective of this study is to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to oral anticoagulation following percutaneous catheter ablation for high risk patients…
- Trial name
- OPTION (NCT03795298)
- Testing
- WATCHMAN FLX Implant, Market-approved OAC
- Where
- 114 sites in United States, Australia and 8 more
- Volunteers
- 1,600 people
- Sponsor
- Boston Scientific Corporation
Non-valvular Atrial Fibrillation
Registry to Evaluate Chinese Real-World Clinical Outcomes in Patients With AF Using the WATCHMAN Left Atrial Appendage Closure Technology
The aim of the registry is to evaluate Chinese real-World clinical outcomes in patients With AF using the WATCHMAN left Atrial appendage closure technology
- Trial name
- RECORD (NCT03917563)
- Testing
- WATCHMAN LAA occluder
- Where
- China
- Volunteers
- 1,050 people
- Sponsor
- Xijing Hospital
AFib
Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial Fibrillation
The purpose of this study is to accurately determine, using an implantable rhythm monitor, the long-term incidence of new atrial fibrillation after ablation of atrial flutter in those treated with spironolactone compared with…
- Trial name
- NCT03929718
- Testing
- Spironolactone, No Spironolactone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Piedmont Healthcare
Atrial Fibrillation (AF)
Safety and Efficacy of Pulmonary Vein Isolation Using Pulsed-field Ablation (PFA) Combined with Either PFA-based Left Atrial Posterior Wall Isolation or Vein of Marshall Ethanol Ablation in Patients with Persistent Atrial Fibrillation
This study is designed to directly compare the safety and efficacy of PFA-based PVI+PWI vs PFA-based PVI+ VoM alcohol ablation in patients with Persistent AF.
- Trial name
- SAVIOR (NCT06878924)
- Volunteers
- 162 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation, Persistent Atrial Fibrillation
CatHeter Ablation of perSistEnd Atrial Fibrillation: Pulmonary Vein Isolation Versus Defragmentation. The CHASE-AF Study
Study design: Randomized prospective comparison of pulmonary vein isolation alone versus a strategy aiming for atrial fibrillation termination by using a stepwise approach consisting of pulmonary vein isolation, biatrial…
- Trial name
- CHASE-AF (NCT01580124)
- Testing
- PVI alone, PVI + Defragmentation + linear lesions
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation
Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)
The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF II) is a multicenter, prospective outpatient disease registry to evaluate the utilization of target-specific antithrombotic agents, such as FXa…
- Trial name
- ORBIT-AF II (NCT01701817)
- Testing
- Patients with Atrial Fibrillation
- Where
- 219 sites in United States, Puerto Rico and 1 more
- Volunteers
- 13,769 people
- Sponsor
- Janssen Scientific Affairs, LLC
Atrial Fibrillation, Percutaneous Coronary Intervention
LAAO Versus NOAC in Patients with AF and PCI
Atrial fibrillation (AF) coincides with coronary artery disease (CAD) shared common risk factors and pathophysiologic pathways. CAD affects approximately 25% of AF patient according to the trial Atrial Fibrillation Follow-up…
- Trial name
- NCT05353140
- Testing
- The WATCHMAN/WATCHMAN FLX device, Rivaroxaban + Clopidogre, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 1,386 people
- Sponsor
- Xijing Hospital
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