Clinical trials: Aphasia
Alzheimer Disease, Early Onset, Alzheimer Disease
Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks
This study attempts to identify two types of AD by using clinical and cognitive tasks and brain imaging. The subtypes of AD are separated into a "typical" group (memory loss) and a "variant" group (language, visuospatial, and…
- Conditions
- Alzheimer Disease, Early Onset, Alzheimer Disease, Alzheimer Disease, Late Onset, Dementia, Alzheimer Type
- Trial name
- EOAD-Subtype (NCT03153371)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Aphasia, Stroke
Escitalopram and Language Intervention for Subacute Aphasia
In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and…
- Trial name
- ELISA (NCT03843463)
- Testing
- Escitalopram 10mg, Computer-delivered naming treatment
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Johns Hopkins University
Stroke, Aphasia
Effects of rTMS Based on Brain Activation During Language Performance in Stroke Patients With Non-fluent Aphasia
The aim of this study is to assess the safety and clinical efficacy of high or low-frequency repetitive transcranial magnetic stimulation based on brain activation with functional near infrared spectroscopy in poststroke…
- Trial name
- NCT02556385
- Testing
- High frequency rTMS, Low frequency rTMS
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Bundang Hospital
Stroke, Aphasia
Adjustment With Aphasia After Stroke: SUPERB
Aims: This exploratory trial will: 1. Explore the feasibility of a definitive/phase III RCT on clinical and cost-effectiveness of peer-befriending for people with aphasia post-stroke. 2.
- Trial name
- SUPERB (NCT02947776)
- Testing
- PEER, USUAL
- Where
- 5 sites in United Kingdom
- Volunteers
- 62 people
- Sponsor
- City, University of London
Stroke, Aphasia
Studying Language With Brain Stimulation in Aphasia
The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.
- Trial name
- NCT05660304
- Testing
- Cortico-cortical paired associative stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Primary Progressive Aphasia
Stimulating the Aging Brain Using Brain and Sensory Stimulation
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA).
- Trial name
- StAB (NCT07650188)
- Testing
- tACS or multisensory stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Aphasia, Stroke
Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke
The aim of this work is to study the effect of transcranial direct current stimulation combined with naming therapy in acute and post-acute stroke comparing four bihemispheric positioning electrodes to a sham condition.
- Trial name
- NCT02101398
- Testing
- eldith DC-stimulator, configuration F7A, eldith DC-stimulator, configuration F7C, eldith DC-stimulator, configuration T5A
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke
Speech Therapy for Aphasia: Comparing Two Treatments
This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking.
- Trial name
- PMvSFA (NCT02153710)
- Testing
- Semantic Feature Analysis therapy, Phonomotor Therapy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Aphasia
Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia
We hypothesize patients who have difficulty with word recall (naming pictures) due to a stroke will experience greater benefit in word recall after receiving a combination of transcranial direct current stimulation (tDCS) and…
- Trial name
- NCT02226796
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Primary Progressive Aphasia
Treating Primary Progressive Aphasia (PPA) Using tDCS
This is a double-blind, sham-controlled, crossover study in which subjects with the non-fluent/agrammatic and semantic variants of primary progressive aphasia (naPPA and svPPA, respectively) will undergo language testing and…
- Trial name
- NCT04566731
- Testing
- Transcranial Direct Current Stimulation (tDCS), Modified Contraint-Induced Language Therapy (mCILT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Aphasia, Acquired, Chronic Stroke
VR and Scrip Training of PWA, Randomized Controlled Trial
The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes.
- Trial name
- VRSTPWA (NCT06722092)
- Testing
- VR-based script training, Conventional script training
- Volunteers
- 105 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Aphasia
Transcranial Alternating Current Stimulation in Post Stroke Aphasia Therapy
This study aims to investigate the efficacy of transcranial alternating current stimulation (tACS) combined with linguistic training for patients with chronic post-stroke aphasia.
- Trial name
- AfatES (NCT07510464)
- Testing
- active 75 Hz transcranial alternating current stimulation
- Where
- Poland
- Volunteers
- 11 people
- Sponsor
- QVITI S.A.
Primary Progressive Aphasia
HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary…
- Trial name
- NCT03805659
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Aphasia, Nonfluent Aphasia
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia.
- Conditions
- Aphasia, Nonfluent Aphasia, Stroke
- Trial name
- NCT00467103
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aphasia, Primary Progressive Aphasia
CB3 Pilot (Communication Bridge: A Person-centered Internet-based Intervention for Individuals With Primary Progressive Aphasia)
This study will evaluate evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA). The aim of the study is to help identify efficacious communication and quality of life interventions for those with PPA…
- Conditions
- Aphasia, Primary Progressive Aphasia, Dementia, Communication
- Trial name
- CB3 Pilot (NCT05697380)
- Testing
- Communication Bridge™
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Chicago
Alzheimer Disease, Primary Progressive Aphasia
Identification of Graphic Markers of Neurocognitive Disorders (MG)
The diagnosis of neurocognitive disorders such as early Alzheimer's disease (AD) or primary progressive aphasia (PPA) is particularly difficult and constantly evolving, often leading to diagnostic erraticity.
- Conditions
- Alzheimer Disease, Primary Progressive Aphasia, Neurocognitive Disorders
- Trial name
- MG (NCT05537688)
- Testing
- Identification of Graphic Markers
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Non-fluent Aphasia
Combined Intervention Program for Non-fluent Aphasia Based on Neuroplasticity
Sequentially applying Melodic Intonation Therapy (MIT) during the subacute phase, followed by Constraint-Induced Aphasia Therapy (CIAT) during the chronic phase
- Trial name
- CIPAN (NCT07759375)
- Testing
- CIPAN = MIT + CIAT, MIT + MIT, CIAT + CIAT
- Volunteers
- 48 people
- Sponsor
- Universidad de Granada
Aphasia, Chronic Stroke
Transcutaneous Vagus Nerve Stimulation in Aphasia After Stroke
Aphasia is an acquired language disorder. Stroke is the most common cause of aphasia, which affects 30% of stroke survivors. Speech and Language Therapy (SLT) can help people with aphasia but it may not be provided at the…
- Trial name
- TRANSLATE (NCT06403475)
- Testing
- Transcutaneous Vagus Nerve Stimulation, Computer Based Speech and Language Therapy (Step by Step)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Stroke, Aphasia
pBFS-guided Dual-target cTBS for Aphasia After Stroke
The objective of this trial is to evaluate the effectiveness and safeness of personalized brain functional sectors (pBFS) technology-guided continuous theta burst stimulation (cTBS) on the inferior frontal gyrus (IFG) combined…
- Trial name
- NCT05957354
- Testing
- active continuous Theta Burst Stimulation
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Changping Laboratory
Aphasia
Interest of Combining Speech Therapy With a Non-invasive Brain Stimulation (tDCS) for the Aphasic Patient
Aphasia is a frequent symptom after a left hemisphere stroke. It has serious impacts on social, family and professional lives. Aphasic patients need to be rehabilitated.
- Trial name
- Taph (NCT02612753)
- Testing
- improvement of language for aphasics patients, tDCs
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805