Clinical trials: Aortic Stiffness
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie)
First, investigators must determine the physiological standards across age classes of myocardial stiffness estimated by Elastography in ultrafast (estimated right ventricular stiffness [VD] and left ventricular [LV]).
- Trial name
- NCT02619825
- Testing
- Echography, Elastography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Aortic Coarctation, Arterial Stiffness
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
Background: Coarctation of the aorta (CoA) can be treated using surgery, balloon angioplasty or stent implantation. Although short-term results are excellent with all three treatment modalities, long term cardiovascular (CV)…
- Conditions
- Aortic Coarctation, Arterial Stiffness, PULSE WAVE VELOCITY, Functional Magnetic Resonance Imaging
- Trial name
- LOVE-COARCT (NCT03262753)
- Testing
- Surgery, Balloon dilation, Stent
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Arteriopathic Disease, Arterial Calcification
The Effects of Hemodialysis Session on Vascular Stiffness
Central blood pressure and pulse wave velocity were measured using a Complior Analyse device before and immediately after the end of the dialysis session.
- Conditions
- Arteriopathic Disease, Arterial Calcification, Complication of Hemodialysis, Aortic Stiffness
- Trial name
- PWV/CP/HD (NCT02443376)
- Testing
- Complior Analyse System, BCM- Body Composition Monitor
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus
Effects of Dapagliflozin on Central Hemodynamics and Urine Albumin Excretion in Patients With Type 2 Diabetes.
This study is designed to test the hypothesis that the treatment-induced reductions in the ambulatory aortic pressure are more pronounced in the group of dapagliflozin than in the group of placebo.
- Trial name
- NCT02887677
- Testing
- Dapagliflozin
- Where
- 3 sites in Greece
- Volunteers
- 85 people
- Sponsor
- Hellenic Society for Medical Education
Aortic Coarctation
Aortic Stiffness by CMR in Aortic Coarctation
This study investigates the correlation between medium-term systemic blood pressure control and aortic stiffness index in adults following coarctation stenting, using cardiac magnetic resonance (CMR) imaging.
- Trial name
- NCT06740461
- Volunteers
- 30 people
- Sponsor
- Assiut University
Decline in Renal Function
Aortic Stiffness in Chronic Kidney Disease Stage 2 to 4
This study aimed to investigate in a cohort with chronic kidney disease the longitudinal relationship between aortic stiffness and renal function and mortality.
- Trial name
- NCT01279460
- Where
- 2 sites in Germany
- Volunteers
- 167 people
- Sponsor
- Technical University of Munich
Hypertension, Aortic Aneurysm
Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)
Aortic stiffness is an important imaging biomarker of vascular aging. The ascending aorta is the most elastic segment, and it is excluded by reference non-invasive method carotid to femoral pulse wave velocity (PWV).
- Conditions
- Hypertension, Aortic Aneurysm, Bicuspid Aortic Valve, Marfan Syndrome
- Trial name
- InSide-CC (NCT05711693)
- Testing
- Laser doppler vibrometry (LDV), heart(cordium) carotid pulse wave velocity (ccPWV), Blood pressure and heart rate measurement, carotid to femoral PWW measurement
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aortic Stiffness, Oxidative Stress
Relationship Between Oxidative Stress and Aortic Stiffness
The goal of this clinical trial is to search about if there is any relationship between the aortic stiffness and oxidative stress response in adolescent football players.
- Conditions
- Aortic Stiffness, Oxidative Stress, Football Player
- Trial name
- NCT06590792
- Testing
- exhaustive exercise training session
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Resistant Hypertensive Patients
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
The ENSURE study is a multi-center, prospective, single-blind, randomized, controlled study of the effect of renal denervation on arterial stiffness and haemodynamics in subjects with uncontrolled hypertension.
- Trial name
- ENSURE (NCT02102126)
- Testing
- Renal denervation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 10th People's Hospital
Aortic Dissection Type A, Acute Kidney Injury Cardiac Surgery
Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery
This single-centre retrospective observational cohort study evaluated the association between preoperative cuff-derived ankle-brachial index (ABI) and postoperative acute kidney injury (AKI) in adults undergoing emergency repair…
- Trial name
- NCT07668830
- Testing
- Preoperative Ankle-Brachial Index
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Chronic Kidney Disease, Cardiovascular Disease
Management of Cardiovascular Disease in Kidney Disease (MaCK) Study
Cardiovascular disease (CVD) is the largest concerns for patients with Chronic kidney disease (CKD). At present time the investigators do not have proven effective strategies to reduce high CVD related deaths in CKD.
- Conditions
- Chronic Kidney Disease, Cardiovascular Disease, Inflammation, Atherosclerosis
- Trial name
- MaCK (NCT03636152)
- Testing
- MRI carotid, APWV, Hydroxychloroquine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Infrarenal Abdominal Aortic Aneurysm
Arterial Stiffness, Blood Pressure and Cardiac Output Study
Comparison of non-invasively obtained central blood pressure using SphygmoCor and invasively recorded central blood pressure in patients with an AAA that will be treated with EVAR.
- Trial name
- ABC (NCT03469388)
- Testing
- Pulse wave analyses; central blood presaure parameters
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Rijnstate Hospital
Primary Hypertension, Secondary Hypertension
HaemoDYNAMICs in Primary and Secondary Hypertension
The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive…
- Conditions
- Primary Hypertension, Secondary Hypertension, Aortic Stenosis, Renal Insufficiency
- Trial name
- DYNAMIC (NCT01742702)
- Testing
- Nitroglycerin 0.25 mg (single dose, no longer given since January 2017), Salbutamol 400 µg (single dose, no longer given since January 2017), L-arginine (10 min infusion, no longer given since January 2017)
- Where
- 2 sites in Finland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tampere University
Large Artery Stiffness, Aortic Disease
Phenotyping Heterogeneity and Regionality of the Aorta
The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern.
- Conditions
- Large Artery Stiffness, Aortic Disease, Aortic Stenosis, Aortic Aneurysm
- Trial name
- PHaRAo (NCT05603520)
- Testing
- Collection of Clinical Data
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Marfan Syndrome
Comparison of Aliskiren vs Negative Controls on Aortic Stiffness in Patients With MFS
Marfan syndrome (MFS) is an inherited disorder of connective tissue with morbidity and mortality from aortic dilatation and dissection.
- Trial name
- NCT01715207
- Testing
- Aliskiren, Atenolol
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Arterial Calcification, Aortic Stiffness
Noninvasive Perioperative Monitoring of Arterial Stiffness, Volume and Nutritional Status in Stable Renal Transplant Recipients
Central blood pressure and pulse wave velocity were measured using a BR 102 Plus PWA device in perioperative time after kidney transplantation
- Conditions
- Arterial Calcification, Aortic Stiffness, High Blood Pressure, Kidney Transplantation
- Trial name
- NCT02908139
- Testing
- BR-102 plus PWA, Tanita MC780 MA S
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Warsaw
Stiffness, Aortic, Cardiac Remodeling, Ventricular
Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a…
- Conditions
- Stiffness, Aortic, Cardiac Remodeling, Ventricular, Vascular Remodeling, Magnetic Resonance Imaging, Functional
- Trial name
- CoATri (NCT03356301)
- Testing
- Cardiac MRI, Applanation tonometry
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Coarctation of the Aorta, Coarctation of Aorta
Effects of Exercise in Patients With Repaired Coarctation of the Aorta
This interventional study will investigate the effects of high-intensity interval training (HIIT) in adults with repaired coarctation of the aorta.
- Trial name
- KOREKT (NCT07771023)
- Testing
- Outpatient high-intensity interval training (HIIT), Home-based high-intensity interval training (HIIT)
- Where
- 2 sites in Slovenia
- Volunteers
- 45 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Artery Disease
Aortic Stiffness and Distensibility as Predictor to Severity of Coronary Artery Disease
Assess the relationship of Aortic root distensibility and stiffness with the extent of coronary artery disease as assessed by SYNTAX score compared to a matched cohort of patients with normal coronary angiography
- Trial name
- NCT03615963
- Testing
- echocardiography and coronary angiography
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University