Clinical trials: Anticholinergic Adverse Reaction
Frailty in Older Adults, Functional Decline
Prevalence of Anticholinergics in Geriatric Patients With Acute Functional Deterioration
This study investigates the anticholinergic burden on patients seen in the Subacute mobile outpatient geriatric clinic in Aalborg, Denmark, between the years of 2024 and 2025.
- Conditions
- Frailty in Older Adults, Functional Decline, Anticholinergic Syndrome
- Trial name
- NCT07165574
- Testing
- No intervention as the study is observational
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aalborg University Hospital
Aging, Benzodiazepine Sedative Adverse Reaction
Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable…
- Conditions
- Aging, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction, Adverse Drug Event
- Trial name
- NUDGE-EHR (NCT04284553)
- Testing
- Order Entry, Open Encounter, Follow-up booster Alert
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Brigham and Women's Hospital
Delirium, Anticholinergic Adverse Reaction
Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:
Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects.
- Conditions
- Delirium, Anticholinergic Adverse Reaction, Alzheimer Disease
- Trial name
- NCT05055895
- Testing
- Anticholinergic burden
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- Gulhane Training and Research Hospital
Anticholinergic Syndrome, Anticholinergic Adverse Reaction
The Effects Of Anticholinergic Burden On Daily Living Activities In Elderly Patients
The anticholinergic burden was calculated based on the medications that the patients had used for more than 10 days. Short-term medications used by patients were not evaluated.
- Conditions
- Anticholinergic Syndrome, Anticholinergic Adverse Reaction, Antispasmodic Adverse Reaction, Antiarrhythmic Drug Adverse Reaction
- Trial name
- NCT05902676
- Volunteers
- 180 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Aging, Benzodiazepine Sedative Adverse Reaction
NUDGE-EHR Replication Trial at Mass General Brigham
Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable…
- Conditions
- Aging, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction, Adverse Drug Event
- Trial name
- NUDGE-EHR (NCT05538065)
- Testing
- Follow-up booster Alert, Pre-commitment, Enhanced Alert
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis (RA), Anticholinergic Adverse Reaction
Anticholinergic Burden and Osteoporosis in Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory rheumatological disease. Use of corticosteroids for more than 3 months in RA treatment is considered an important risk factor in terms of developing…
- Conditions
- Rheumatoid Arthritis (RA), Anticholinergic Adverse Reaction, Fractures, Bone
- Trial name
- NCT06812481
- Testing
- Anticholinergic load was calculated using anticholinergic cognitive load (ACB)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Balikesir University
Anticholinergic Adverse Reaction
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older
Medications with anticholinergic properties are frequently prescribed for several conditions in older age; for example cardiovascular drugs (e.g. digoxin, furosemide), urologicals (e.g.
- Trial name
- REGENERATE (NCT04660838)
- Testing
- ACB intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Parkinson's Disease, Neurogenic Bladder
Safety and Efficacy of botulinumA Toxin (BotoxA) for Treatment of Neurogenic Bladder of Parkinson's Disease
The basic nerve deficit of Parkinson's disease (PD) leads to lower urinary tract symptoms of frequency, urgency and urge urinary incontinence. Lower urinary tract symptoms tend to occur at more advanced stages of PD.
- Conditions
- Parkinson's Disease, Neurogenic Bladder, Urinary Incontinence, Clostridium Botulinum Toxin Adverse Reaction
- Trial name
- NCT01421719
- Testing
- Cystoscopic injection of Botox into the urinary bladder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Sedative Adverse Reaction, Anticholinergic Adverse Reaction
Pharmacist Led Intervention to Improve Medication Use in Older In-patients Living With Frailty: the Drug Burden Index
Older people in Canada commonly take multiple medicines for their health conditions. Certain medicines, especially when taken together can lead to serious harms, such as falls.
- Trial name
- NCT03698487
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Emily
Urologic Diseases, Overactive Bladder Syndrome
Trigonal vs Non Trigonal Botox Injection in OAB.
The investigators attend to conduct a prospective randomized study to assess safety and efficacy of trigonal-involved vs. trigonal-sparing botox injection technique, quality of life measurement and post-injection anticholinergics…
- Conditions
- Urologic Diseases, Overactive Bladder Syndrome, Quality of Life, Anticholinergic Syndrome
- Trial name
- NCT03533062
- Testing
- botulinum toxin A
- Volunteers
- 80 people
- Sponsor
- Mansoura University