Clinical trials: Antibiotic Stewardship
Common Infections, Urinary Tract Infections
VA Quality Enhancement Research Initiative (QUERI) CARRIAGE VAST
Antimicrobial-resistant and healthcare-associated pathogens are a global health threat. The goals of antimicrobial stewardship are to minimize unnecessary and inappropriate antimicrobial use as a means to combat antimicrobial…
- Conditions
- Common Infections, Urinary Tract Infections, Respiratory Tract Infections
- Trial name
- QUERI VAST (NCT07877662)
- Testing
- Videoconference Antimicrobial Stewardship Team
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Office of Research and Development
Hospital-acquired Pneumonia
Impact of Antimicrobial Stewardship on Outcomes of Patients With Hospital-acquired Pneumonia Due to Gram-negative Bacilli - A Before-after Study
Hospital-acquired pneumonia (HAP) is one of the most frequent complications and the main cause of antibiotics use in hospitalized patients, particularly in intensive care units (ICUs).
- Trial name
- ORACLE (NCT04937075)
- Testing
- No intervention
- Where
- 2 sites in France
- Volunteers
- 420 people
- Sponsor
- Nantes University Hospital
Infectious Disease
Antibiotic Outbreak, Risk Factors for Never Event, Prediction of Inappropriate Use
In order to decrease inappropriate antibiotic use, drivers of inappropriate use must be identified locally. This study will focus on the MOST inappropriate use, which are defined as 'never events'.
- Trial name
- NCT03489330
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Hematologic Diseases, Bacteremia Sepsis
Effect of dRAST on Treatment for Bacteremia in Patients With Hematologic Diseases
The purpose of this study is to evaluate whether the use of direct rapid antibiotic susceptibility test (dRAST), in addition to the current standard antibiotic susceptibility test, can increase the proportion of patients with…
- Trial name
- NCT03611257
- Testing
- dRAST, Current standard method
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Seoul National University Hospital
Patients at High Risk of Antibacterial Treatment Upon Admission
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens
Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide.
- Trial name
- PILGRIM (NCT03765528)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital of Cologne
Respiratory Tract Infections
Point-of-care Testing of Respiratory Pathogens at Pediatric Emergency Room
The main objective of the trial is to evaluate the effect of point-of-care testing of respiratory pathogens at a pediatric emergency room on the antibiotic consumption and hospital admissions in acutely ill children.
- Trial name
- Hevi-RCT (NCT03932942)
- Testing
- QIAstat at pediatric emergency room
- Where
- Finland
- Volunteers
- 1,350 people
- Sponsor
- University of Oulu
Communicable Diseases
Computerized Antibiotic Stewardship Study
Prescribing antibiotics frequently poses problems in practice, since patients don't always receive the right dosage of the right antibiotic for the right period of time.
- Trial name
- COMPASS (NCT03120975)
- Testing
- Computerized decision support and audit & feedback, Audit & Feedback, Standard antibiotic stewardship
- Where
- 3 sites in Switzerland
- Volunteers
- 16,176 people
- Sponsor
- Benedikt Huttner
Community Acquired Infections
Clinical and Ecological Impact of a Primary Care Antimicrobial Stewardship Program Based on Telematic Educational Interviews (TELÉMACO Trial)
Brief Summary: Open-label, cluster randomized, multicenter clinical trial to evaluate the clinical and ecological impact of a Primary Care ASP based on telematic educational interviews.
- Trial name
- TELÉMACO (NCT06706583)
- Testing
- Telematic educational interviews + standard training, Standard training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Staphylococcus Aureus
Antimicrobial Drug Use and Resistant Staphylococcus Aureus
The purpose of this investigation is to study the relationships between antimicrobial stewardship program efforts, antimicrobial drug use, and infection control efforts to the incidence rates of hospital acquired infections with…
- Trial name
- NCT01075451
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Virginia Commonwealth University
Resistance Bacterial
Impact of Antimicrobial Stewardship Programs in the Global Setting
Antimicrobial resistance is one of the greatest threats to human health, and is driven by inappropriate antimicrobial use. Antimicrobial stewardship programs (ASPs) improve the use of antimicrobials in hospitals.
- Trial name
- PEARL (NCT03382470)
- Testing
- Antimicrobial stewardship advice
- Where
- Sri Lanka
- Volunteers
- 3,115 people
- Sponsor
- Duke University
Antibiotic, Healthcare Associated Infection
Evaluating Antibiotic Stewardship Assisted by Computer in the University Hospital of Nancy (MACABAO)
Antibiotic resistance is one of the most pressing health threats that mankind faces now and in the coming decades. Antibiotic resistance leads to longer hospital stays, higher medical costs and increased mortality.
- Trial name
- MACABAO (NCT04976829)
- Testing
- Antibiotic stewardship and healthcare-associated infections surveillance assisted by computer
- Volunteers
- 100,000 people
- Sponsor
- Central Hospital, Nancy, France
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Lower Respiratory Tract Infection
Procalcitonin and Lung Ultrasonography Guided Antibiotherapy in Emergency Departments
Acute respiratory infections are a common reason of attendance at emergency departments. It is also the main reason of unnecessary antibiotic prescription.
- Trial name
- PLUS-IS-LESS (NCT05463406)
- Testing
- The PLUS algorithm, Usual care
- Where
- 9 sites in Switzerland
- Volunteers
- 1,407 people
- Sponsor
- Dr Boillat-Blanco Noemie
Bloodstream Infection Multidrug-resistant Gram-negative Bacteria
Combating Multidrug-resistant Gram-negative Bacteria in Africa Through Diagnostic and Antimicrobial Stewardship
Antimicrobial resistance (AMR) is a major threat to public health and the well-being of humans, with high mortality rates of infections caused by MDR GNB.
- Trial name
- ComBac (NCT07820332)
- Testing
- Treatment according to AMR algorithm
- Volunteers
- 1,320 people
- Sponsor
- Universität des Saarlandes
The Use of Antimicrobial Stewardship in in General Practice (Family Medicine), Respiratory Tract Infections (RTI)
Optimal Implementation of Antimicrobial Stewardship in General Practice
This trial aims to increase the use of antimicrobial stewardship resources when treating patients with respiratory tract infections. This trial is set in Australian general practices (family medicine or primary care).
- Trial name
- OPTIMAS-GP (NCT06953804)
- Testing
- Antimicrobial stewardship activities delivered through Virtual Network, Antimicrobial stewardship activities delivered through Integrated Network activities
- Where
- 4 sites in Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Wollongong
Infection
DetermInants of Antimicrobial Use aNd De-escalAtion in Critical Care (DIANA)
DetermInants of Antimicrobial use aNd de-escalAtion in critical care (DIANA study), is a multicenter, international, prospective, observational cohort study, aiming to describe the rate of de-escalation as well as the associated…
- Trial name
- DIANA (NCT02920463)
- Where
- Belgium
- Volunteers
- 1,495 people
- Sponsor
- University Hospital, Ghent
Ventilator Associated Pneumonia
Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care
Increasing emergence of multidrug resistant (MDR) bacteria worldwide is now considered one of the most urgent threats to global health.
- Trial name
- ASPIC (NCT05124977)
- Testing
- Antimicrobial Stewardship, Standard management
- Where
- France
- Volunteers
- 590 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Procalcitonin to Guide Antibiotic Stop in Neurocritical Care Patients.
Antibiotic overconsumption has been considered as one of the major contributive factors of the emergence of multidrug resistant bacteria, a serious threat particularly in intensive care units.
- Trial name
- NCT03683693
- Testing
- Procalcitonin group
- Where
- Belgium
- Volunteers
- 132 people
- Sponsor
- General Hospital Groeninge
Pneumonia, Urinary Tract Infection
Reducing Overuse of Antibiotics at Discharge Home
The goal of this two-arm parallel cluster-randomized trial of 40 hospitals is to test the effectiveness of the ROAD Home Intervention on days of antibiotic overuse at discharge in patients hospitalized with community-acquired…
- Conditions
- Pneumonia, Urinary Tract Infection, Antibiotic Stewardship, Care Transition
- Trial name
- ROAD Home (NCT06106204)
- Testing
- ROAD Home Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Utah