Clinical trials: Anesthesia Outcomes, open to volunteers
Pain, Opioid Use
NOL-Guided vs Conventional Intraoperative Opioid Infusion on Outcomes in Geriatric Patients
The aim of this study is to compare the effects of conventional methods and goal-directed therapy guided by pain monitoring on total remifentanil dosage, wake-up time, and complications in geriatric patients undergoing lumbar…
- Conditions
- Pain, Opioid Use, Geriatric Anesthesia
- Trial name
- NCT07075003
- Testing
- nociceptive level
- Volunteers
- 80 people
- Sponsor
- Saglik Bilimleri Universitesi
Postoperative Airway Complications
The Impact of Endotracheal Cuff Pressure Assessment Using a Cuff Pressure Manometer Compared With the Traditional Palpation Method on Postoperative Outcomes
The aim of this prospective observational study is to evaluate the effect of endotracheal cuff pressure management on postoperative complications in patients undergoing surgery under general anesthesia.
- Trial name
- ECP (NCT07427173)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Osteo Arthritis Knee and Hip, Osteo Arthritis
General Anaesthesia vs Spinal Anaesthesia: Patient Outcomes and Success in Outpatient Primary Total Knee and Hip Arthroplasty
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are common operations used to treat severe joint disease, most often caused by osteoarthritis.
- Conditions
- Osteo Arthritis Knee and Hip, Osteo Arthritis, Inflammatory Joint Disease (IJD)
- Trial name
- GASPS (NCT07334132)
- Testing
- General Anaesthesia, Spinal Anesthesia (bupivacaine)
- Volunteers
- 600 people
- Sponsor
- Region Örebro County
Infection, Pneumonia
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery
PENGUIN is a pragmatic multi-center trial investigating the effects of pre-operative mouthwash and perioperative oxygen on the incidences of pneumonia and surgical site infection (SSI) following major abdominal surgery.
- Conditions
- Infection, Pneumonia, Surgical Site Infection, Wound Infection
- Trial name
- PENGUIN (NCT04256798)
- Testing
- Chlorhexidine mouthwash, Oxygen
- Where
- 37 sites in Brazil, India and 3 more
- Volunteers
- 12,942 people
- Sponsor
- University of Birmingham
Nephrectomy / Methods, Intraoperative Hypothermia
Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy
The goal of this observational study is to learn whether warming patients before surgery, called "prewarming," affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned…
- Conditions
- Nephrectomy / Methods, Intraoperative Hypothermia, Hyperlactatemia
- Trial name
- NCT07702487
- Testing
- Preoperative active warming (prewarming)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Beyzanur Aydoğdu
Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia
Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia
The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing…
- Conditions
- Intraoperative Nausea-retching-vomiting Episodes, Spinal Aneshtesia, Ceserean Section, Antiemetic Therapy
- Trial name
- NCT07740577
- Testing
- Ondansetron 4mg, metoclopramide
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sanliurfa Education and Research Hospital
Postoperative Acute Kidney Injury
Processed Electroencephalography-guided General Anesthesia and Outcomes in Major Abdominal Surgery
This study aims to evaluate whether the reduction in the amount of intraoperative norepinephrine required to prevent hypotension, facilitated by processed electroencephalography (pEEG) -guided general anesthesia, will lead to a…
- Trial name
- NCT06753409
- Testing
- Processed electroencephalography (pEEG) Guided General Anesthesia, Non-pEEG-Guided General Anesthesia (with blinded pEEG monitoring)
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Assiut University
Hip Fracture, Postoperative Recovery
Total Intravenous Versus Inhalational Anesthesia in Patients Undergoing Hip Fracture Surgery
This prospective observational study aims to compare total intravenous anesthesia (TIVA) with sevoflurane-based inhalational anesthesia in patients aged 65 years and older undergoing hip fracture surgery under general anesthesia.
- Trial name
- NCT07860996
- Testing
- Propofol-based Total Intravenous Anesthesia, Sevoflurane-based Inhalational Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Chronic Sinusitis, Postoperative Pain
Opioid-Free Anesthesia in FESS: A Prospective ERAS Study
1. Information for Patients and Families What is this study about? When patients undergo functional endoscopic sinus surgery (FESS), strong pain relievers called opioids are traditionally used during anesthesia.
- Conditions
- Chronic Sinusitis, Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Surgical Field Visibility
- Trial name
- OFA-FESS (NCT07812389)
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Filiz Kaya
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Surgery, Anesthesia, Local
Effect of Fasting on Patient Outcomes After Wide-Awake, Local Anesthesia-only, No Tourniquet (WALANT) Procedures
The purpose of this study is to determine whether eating solid food prior to undergoing a wide awake local-only no tourniquet (WALANT) procedure reduces anxiety in patients or has any effect on outcomes.
- Conditions
- Surgery, Anesthesia, Local, Fasting
- Trial name
- NCT05819801
- Testing
- Non-fasting, Fasting
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of California, Irvine
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Rotator Cuff Tear Repair, Interscalene Blocks
Preoperative Versus Postoperative Interscalene Block in Arthroscopic Rotator Cuff Repair
This study is evaluating whether the timing of an interscalene nerve block affects pain control and recovery after arthroscopic rotator cuff repair surgery.
- Conditions
- Rotator Cuff Tear Repair, Interscalene Blocks, Rotator Cuff Tears
- Trial name
- ISB-ARCR (NCT07689448)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istinye University
Perioperative Respiratory Adverse Events, Anesthesia Outcomes
Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia.
The goal of this multicentre, double-blind, randomised controlled trial study is to learn if the use of a nasal spray to open the nasal passages and increase airflow before surgery can reduce the occurrence of perioperative…
- Trial name
- NARWHAL (NCT07000877)
- Testing
- Decongestant nasal spray (oxymetazoline hydrochloride (0.05%))
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Telethon Kids Institute
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Postoperative Recovery in Children
Development and Validation of the Paediatric Scale for Quality of Recovery in the Post-Anaesthesia Care Unit
This project aims to develop and test a new questionnaire to measure how well children recover in the post-anaesthesia care unit (PACU).
- Trial name
- PedSQoR-PACU (NCT07610915)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Breast Cancer, Breast Cancer Female
Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial
The LOLIPOP Trial is a large (n=4,300 patients) pragmatic, international, multicentre, prospective, randomised, double blind, placebo-controlled, parallel assessment, safety and effectiveness superiority study.
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Conserving Surgery, Mastectomy
- Trial name
- LOLIPOP (NCT05072314)
- Testing
- lidocaine 2% and 10%
- Where
- 49 sites in Australia, Hong Kong and 2 more
- Volunteers
- 4,300 people
- Sponsor
- Monash University
Postoperative Delirium, Postoperative Stroke
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared…
- Conditions
- Postoperative Delirium, Postoperative Stroke, Postoperative Cognitive Dysfunction
- Trial name
- PRECISION (NCT05595954)
- Testing
- Preoperative data collection, Intraoperative NIRS, Intraoperative TCD
- Where
- 4 sites in Switzerland, United Kingdom
- Volunteers
- 500 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Cognitive Dysfunction, Orthopedic Procedures
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia.
- Conditions
- Postoperative Cognitive Dysfunction, Orthopedic Procedures, Postoperative Pain Management, Hip Fracture
- Trial name
- REMIND-ORTHO (NCT07113483)
- Testing
- Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Surgery, Anesthesia
Russian Registry of Surgical OutcomeS
Identification of risk factors that cause a high probability of an unfavorable outcome in the postoperative period is an urgent problem.
- Conditions
- Surgery, Anesthesia, Outcome, Fatal, Complication
- Trial name
- RuSOS (NCT06146270)
- Where
- 16 sites in Russia
- Volunteers
- 162,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists