Hip FractureNCT07860996
Total Intravenous Versus Inhalational Anesthesia in Patients Undergoing Hip Fracture Surgery
An observational study of Hip Fracture and Postoperative Recovery, run by Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This prospective observational study aims to compare total intravenous anesthesia (TIVA) with sevoflurane-based inhalational anesthesia in patients aged 65 years and older undergoing hip fracture surgery under general anesthesia. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Hip Fracture, Postoperative Recovery
- What is being tested?
- Propofol-based Total Intravenous Anesthesia and Sevoflurane-based Inhalational Anesthesia
- Type of treatment
- Injection or infusion
- How many people
- 110 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 30 Sep 2026to 30 Mar 2027
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Study population: Patients aged 65 years or older undergoing hip fracture surgery under general anesthesia at Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital. Participants will be observed according to the anesthesia technique used as part of routine clinical practice: propofol-based total intravenous anesthesia or sevoflurane-based inhalational anesthesia.
Who may be able to join
- Age 65 years or older
- ASA physical status I-III
- Scheduled to undergo elective or emergency hip fracture surgery under general anesthesia
- Provision of informed consent by the patient and/or legal representative
Who cannot join
- Refusal to participate in the study
- ASA physical status IV-V
- Severe pre-existing neurological or psychiatric disorders, including advanced dementia or severe cognitive impairment preventing communication
- Known hypersensitivity or allergy to propofol or sevoflurane
- History of chronic heavy opioid or sedative substance use
- Inability to communicate in Turkish or to understand and complete the QoR-40 questionnaire
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital
Istanbul, Istanbul, 34000
Sule Altuncu, MD, +90 216 606 33 00, sule.621@hotmail.com
About this study
Official title: Effect of Total Intravenous Anesthesia Versus Inhalational Anesthesia on Postoperative Quality of Recovery and Cognitive Outcomes in Patients Undergoing Hip Fracture Surgery
This prospective observational study aims to compare total intravenous anesthesia (TIVA) with sevoflurane-based inhalational anesthesia in patients aged 65 years and older undergoing hip fracture surgery under general anesthesia. The study will evaluate postoperative quality of recovery using the Quality of Recovery-40 (QoR-40) questionnaire and cognitive outcomes, including postoperative delirium and cognitive status. Pain scores, opioid consumption, recovery room stay, postoperative complications, and patient satisfaction will also be recorded. The anesthesia technique will be determined by the attending anesthesiologist as part of routine clinical practice, and the researchers will not interfere with the choice of anesthesia.
Read the detailed description
This is a prospective, single-center observational study involving patients aged 65 years and older who undergo hip fracture surgery under general anesthesia. Patients will be followed according to the anesthesia technique used during routine clinical care: propofol-based total intravenous anesthesia (TIVA) or sevoflurane-based inhalational anesthesia. No intervention or modification of routine anesthesia management will be performed by the investigators.
Demographic characteristics, ASA physical status, comorbidities, preoperative Quality of Recovery-40 (QoR-40) scores, and Mini-Mental State Examination (MMSE) scores will be recorded. Intraoperative data, including anesthesia and surgery duration, hemodynamic parameters, extubation time, and anesthetic and analgesic drug consumption, will also be collected.
On postoperative day 1, QoR-40, numerical rating scale (NRS) pain scores, and postoperative delirium using the 3D-CAM will be assessed. On postoperative day 2, QoR-40 and pain assessments will be repeated, and postoperative opioid consumption, post-anesthesia care unit stay, complications, and patient satisfaction will be recorded. Postoperative questionnaires and cognitive assessments will be performed by an investigator blinded to the anesthesia technique.
- Conditions
- Hip Fracture, Postoperative Recovery
- Being tested
- Propofol-based Total Intravenous Anesthesia, Sevoflurane-based Inhalational Anesthesia
- Keywords
- TIVA, Inhalational Anesthesia, Quality of Recovery-40 (QoR-40), Postoperative Delirium, Cognitive Function
- Medical subject headings
- Hip Fractures, Emergence Delirium
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Propofol-based Total Intravenous AnesthesiaOther
Propofol-based total intravenous anesthesia administered according to routine clinical practice during hip fracture surgery.
Sevoflurane-based Inhalational AnesthesiaOther
Sevoflurane-based inhalational anesthesia administered according to routine clinical practice during hip fracture surgery.
| Study group | Role | What they receive |
|---|---|---|
| TIVA | Patients undergoing hip fracture surgery under general anesthesia who receive propofol-based total intravenous anesthesia (TIVA) as part of routine clinical care. The anesthesia technique is determined by the attending anesthesiologist, and the investigators do not interfere with treatment selection. Receives: Other: Propofol-based Total Intravenous Anesthesia | |
| Sevoflurane | Patients undergoing hip fracture surgery under general anesthesia who receive sevoflurane-based inhalational anesthesia as part of routine clinical care. The anesthesia technique is determined by the attending anesthesiologist, and the investigators do not interfere with treatment selection. Receives: Other: Sevoflurane-based Inhalational Anesthesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quality of Recovery-40 (QoR-40) Score on Postoperative Day 1
Postoperative quality of recovery will be assessed using the Quality of Recovery-40 (QoR-40) questionnaire. The QoR-40 consists of 40 items evaluating five dimensions of recovery: physical comfort, emotional state, physical independence, psychological support, and pain. Higher total scores indicate better quality of recovery.The total score ranges from 40 to 200, with higher scores indicating better postoperative recovery.
Measured: Postoperative day 1
Secondary outcomes (6)
Quality of Recovery-40 (QoR-40) Score on Postoperative Day 2
Quality of recovery will be reassessed on postoperative day 2 using the Quality of Recovery-40 (QoR-40) questionnaire. The total score ranges from 40 to 200, with higher scores indicating better postoperative recovery.
Measured: Postoperative day 2
Incidence of Postoperative Delirium
Postoperative delirium will be assessed using the 3D-CAM assessment.
Measured: Postoperative day 1
Postoperative Pain Intensity
Postoperative pain intensity will be evaluated using the Numerical Rating Scale (NRS).
Measured: Postoperative days 1 and 2
Postoperative Opioid Consumption
Total postoperative opioid consumption will be recorded from routine clinical records.
Measured: Up to postoperative day 2
Post-Anesthesia Care Unit Length of Stay
Duration of stay in the post-anesthesia care unit (PACU) will be recorded.
Measured: From admission to discharge from the PACU
Incidence of Postoperative Complications
Postoperative complications occurring during the study observation period will be recorded.
Measured: Up to postoperative day 2
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Oct 2026
- Study start30 Sep 2026
- Primary completion30 Mar 2027 (estimated)
- Study completion30 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Hip FractureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 110 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07860996
- Sponsor's protocol ID
- 2026/493
- Status last verified
- Oct 2026
- First submitted
- 1 Oct 2026
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared publicly due to participant confidentiality and data protection considerations.
Publications
Myles PS, Myles DB, Galagher W, Chew C, MacDonald N, Dennis A. Minimal Clinically Important Difference for Three Quality of Recovery Scales. Anesthesiology. 2016 Jul;125(1):39-45. doi: 10.1097/ALN.0000000000001158.
PubMed 27159009Myles PS, Weitkamp B, Jones K, Melick J, Hensen S. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000 Jan;84(1):11-5. doi: 10.1093/oxfordjournals.bja.a013366.
PubMed 10740540