Hip FracturesNCT07873918
Mortality and Predictors of In-hospital Mortality Among Geriatric Patients With Hip Fracture
An observational study of Hip Fractures and In-hospital Mortality, run by Assiut University.
Trial summary
To assess the incidence of in-hospital mortality among geriatric patients with hip fractures and to identify its potential predictors Read more about this study
- Who is it for?
- Ages 65 months and older
- Conditions the study is for
- Hip Fractures, In-hospital Mortality
- How many people
- 141 participants
- Where
- No sites listed yet
- Study dates
- Mar 2027to Apr 2028
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 months and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients aged ≥65 years diagnosed with a hip fracture and admitted to the Trauma Unit during the study period.
Who may be able to join
- patients aged ≥65 years.
- Patients diagnosed with a hip fracture and admitted to the Trauma Unit during the study period.
- Patients who provide informed consent to participate in the study, either personally or through their caregiver when appropriate.
Who cannot join
- patients younger than 65 years.
- Peri-prosthetic hip fractures.
- Pathological hip fractures.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Incidence and Predictors of In-Hospital Mortality Among Geriatric Patients With Hip Fractures
To assess the incidence of in-hospital mortality among geriatric patients with hip fractures and to identify its potential predictors
Read the detailed description
Population ageing is a major global demographic transition. In 2020, approximately 1 billion people worldwide were aged 60 years or older. This number is projected to increase to 1.4 billion by 2030, when approximately one in six people globally will be aged ≥60 years. In Egypt, approximately 9.77 million people are aged ≥60 years, representing nearly 10% of the total population.
Hip fractures are a major health problem among older adults, causing substantial morbidity, functional decline, loss of independence, prolonged hospitalization, and increased mortality .
Falls are the predominant mechanism of hip fracture in older adults, with more than 90% of fractures attributable to falls, . This emphasizes the importance of underlying skeletal fragility in addition to fall characteristic .
Osteoporosis is a major contributor to skeletal fragility and susceptibility to hip fracture after low-energy trauma . BMI also influences both fracture risk and prognosis; low BMI is associated with greater fracture susceptibility, while underweight patients have higher mortality after hip fracture .
Comorbidities may further increase fracture susceptibility and affect outcomes. Diabetes, hypertension, cardiovascular disease, and chronic kidney disease have been associated with increased fracture risk among older adults .
Hip fractures are associated with considerable in-hospital mortality, while outcomes vary according to patient characteristics, comorbidity burden, and clinical management. However, prospective studies identifying independent predictors of in-hospital mortality, particularly in Egyptian geriatric populations, remain limited .
Therefore, this study aims to determine the incidence of in-hospital mortality and identify its predictors among geriatric patients with hip fractures
- Conditions
- Hip Fractures, In-hospital Mortality
- Medical subject headings
- Hip Fractures
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of In-Hospital Mortality
The study participants will be followed from hospital arrival and initial diagnosis of hip fracture, through their subsequent surgical management, and throughout the postoperative period until hospital discharge or in-hospital death, whichever occurs first
Measured: About 1 month from hospital arrival till in-hospital death or discharge
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Oct 2026
- Study startMar 2027 (estimated)
- Primary completionApr 2028 (estimated)
- Study completionApr 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (14)Papers the sponsor has linked to this study.
- Other trials for Hip FracturesStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 141 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Moetaz Mahmoud Attya, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07873918
- Sponsor's protocol ID
- mortality in geriatrics
- Status last verified
- Oct 2026
- First submitted
- 2 Oct 2026
- Last updated
- 14 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Van Heghe A, Mordant G, Dupont J, Dejaeger M, Laurent MR, Gielen E. Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis. Calcif Tissue Int. 2022 Feb;110(2):162-184. doi: 10.1007/s00223-021-00913-5. Epub 2021 Sep 30.
PubMed 34591127Abdelnasser MK, Khalifa AA, Amir KG, Hassan MA, Eisa AA, El-Adly WY, Ibrahim AK, Farouk OA, Abubeih HA. Mortality incidence and its determinants after fragility hip fractures: a prospective cohort study from an Egyptian level one trauma center. Afr Health Sci. 2021 Jun;21(2):806-816. doi: 10.4314/ahs.v21i2.41.
PubMed 34795739Covino M, Vitiello R, De Matteis G, Bonadia N, Piccioni A, Carbone L, Zaccaria R, Cauteruccio M, Ojetti V, Franceschi F. Hip Fracture Risk in Elderly With Non-End-Stage Chronic Kidney Disease: A Fall Related Analysis. Am J Med Sci. 2022 Jan;363(1):48-54. doi: 10.1016/j.amjms.2021.06.015. Epub 2021 Jul 10.
PubMed 34256032Gerber Y, Melton LJ 3rd, McNallan SM, Jiang R, Weston SA, Roger VL. Cardiovascular and noncardiovascular disease associations with hip fractures. Am J Med. 2013 Feb;126(2):169.e19-26. doi: 10.1016/j.amjmed.2012.06.032.
PubMed 23331448Zhu YY, Wei HF, Li S, Li L, Wang P, Pan HF. Associations of chronic disease status and the risk of new-onset hip or femoral fractures in older population. J Orthop. 2025 May 27;68:149-156. doi: 10.1016/j.jor.2025.05.049. eCollection 2025 Oct.
PubMed 40519338Wallander M, Axelsson KF, Nilsson AG, Lundh D, Lorentzon M. Type 2 Diabetes and Risk of Hip Fractures and Non-Skeletal Fall Injuries in the Elderly: A Study From the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). J Bone Miner Res. 2017 Mar;32(3):449-460. doi: 10.1002/jbmr.3002. Epub 2016 Oct 31.
PubMed 27664946Park HY, Han K, Kim Y, Kim YH, Sur YJ. The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes - A longitudinal nationwide population-based study. Bone. 2021 Jan;142:115691. doi: 10.1016/j.bone.2020.115691. Epub 2020 Oct 15.
PubMed 33069920Modig K, Erdefelt A, Mellner C, Cederholm T, Talback M, Hedstrom M. "Obesity Paradox" Holds True for Patients with Hip Fracture: A Registry-Based Cohort Study. J Bone Joint Surg Am. 2019 May 15;101(10):888-895. doi: 10.2106/JBJS.18.01249.
PubMed 31094980Park CH, Lee SH, Lee R, Kim DY, Cho MR, Song SK. Effects of body mass index on mortality in elderly patients with hip fractures. Medicine (Baltimore). 2024 Aug 2;103(31):e39157. doi: 10.1097/MD.0000000000039157.
PubMed 39093801Kim SH, Yi SW, Yi JJ, Kim YM, Won YJ. Association Between Body Mass Index and the Risk of Hip Fracture by Sex and Age: A Prospective Cohort Study. J Bone Miner Res. 2018 Sep;33(9):1603-1611. doi: 10.1002/jbmr.3464. Epub 2018 Jun 15.
PubMed 29750839Ruggiero C, Baroni M, Xenos D, Parretti L, Macchione IG, Bubba V, Laudisio A, Pedone C, Ferracci M, Magierski R, Boccardi V, Antonelli-Incalzi R, Mecocci P. Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices. Ageing Res Rev. 2024 Jan;93:102130. doi: 10.1016/j.arr.2023.102130. Epub 2023 Nov 27.
PubMed 38030092Yang Y, Komisar V, Shishov N, Lo B, Korall AM, Feldman F, Robinovitch SN. The Effect of Fall Biomechanics on Risk for Hip Fracture in Older Adults: A Cohort Study of Video-Captured Falls in Long-Term Care. J Bone Miner Res. 2020 Oct;35(10):1914-1922. doi: 10.1002/jbmr.4048. Epub 2020 Jul 6.
PubMed 324021363. Reddy BA, Sreenath M, Macherla VG, et al. Epidemiological trends and risk factors of hip fractures in elderly patients: a retrospective study. Eur J Cardiovasc Med. 2025;15(10):200-205.
1. World Health Organization. Ageing and health. 2025