Clinical trials: Anesthesia Induction
Inhalation Anesthesia, Dexmedetomidine
The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
Sevoflurane is a volatile agent easy to control thanks to the Minimum Alveolar Concentration (MAC) allowing its titration for an optimal depth of anesthesia.
- Conditions
- Inhalation Anesthesia, Dexmedetomidine, Sevoflurane, Laparoscopy
- Trial name
- NCT05615194
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Anesthesia
EEG Studies of Sevoflurane-Induced General Anesthesia
The investigators are performing this research study to find out how and where the anesthetic drugs sevoflurane and ketamine act in the brain.
- Trial name
- NCT03503578
- Testing
- Sevoflurane, Ketamine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypotension on Induction
Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension After Induction of General Anaesthesia in Adult Patients With Chronic Liver Disease
Baseline Measurements For the ultrasound parameters, it is the average of three readings In supine position . The investigators will continuously monitoring during induction and 10 minutes after.
- Trial name
- NCT07370103
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, General, Laparoscopic Surgery
Effect of Preoperative Pregabalin on Propofol Induction Dose
The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia.
- Trial name
- NCT01158859
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
EEG Data Analysis, Orthopedic Surgery
Characteristic Electroencephalogram of General Anesthesia
Patients were enrolled according to predefined inclusion and exclusion criteria. Following surgical admission, standard monitoring was initiated, including continuous assessment of heart rate, blood pressure, electrocardiogram…
- Trial name
- NCT07468162
- Testing
- After the use of sedative drugs, the changes in the electroencephalogram (EEG) spectrum were observed with an EEG monitor
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neurotoxic Effect of Sevoflurane-Based Anaesthesia
Evaluation of Neurotoxic Effect of Sevoflurane-Based AnaesthesiaGuided by Short-Term Olfactory Identification
Nowadays there is increasing doubts about the safety of anesthesia . Anesthesiologists have to console the worried patients, who are anxious about the potential risks of anesthetic-induced brain damage, by suggesting that any…
- Trial name
- NCT03726580
- Testing
- Sevoflurane
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Tanta University
Preoxygenation
Verbal Breathing Coaching to Improve Preoxygenation and Extend Safe Apnea Time in Anesthesia
This study explores whether simply guiding patients to breathe slowly and calmly before anesthesia can help improve oxygen levels and keep them safe for longer during induction.
- Trial name
- NCT07565259
- Testing
- Verbal Breathing Coaching
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prince Sultan Military Medical City
Anxiety State, Child Behavior
The Effect of Child Choice With Accompanying Parent on Postoperative Delirium During Induction of Anesthesia
Induction of anesthesia can be distressing both for children and their parents. Nonpharmacological behavioral interventions can reduce the anxiety of children without significant adverse effects as seen with sedative drugs.
- Conditions
- Anxiety State, Child Behavior, Postoperative Delirium
- Trial name
- NCT05931770
- Testing
- Selection of parent(mother or father) according to children preference, Parent (mother or father) selection according to parents' preference
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Preeclampsia, Intracranial Pressure Increase
Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic Management
Preeclampsia is a serious condition associated with complications such as pulmonary edema, placental abruption, hemolysis, thrombocytopenia, and cardiac, renal, and neurological complications, occurring at a rate of 2.7-8% in…
- Conditions
- Preeclampsia, Intracranial Pressure Increase, Pregnancy; Anesthesia, Adverse Effect, Central Nervous System
- Trial name
- NCT06522295
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Hypoglycemia; Iatrogenic, Anesthesia
Fasting Induced Hypoglycaemia in Anaesthetised Paediatric Patients
Fasting is a requirement to safely anesthetise patients referred for elective procedure, using the traditional 6/4/2 rule (6h for solid food or formula milk, 4h for breast milk and 2h for clear fluids), applied to all patients…
- Conditions
- Hypoglycemia; Iatrogenic, Anesthesia, Pediatrics
- Trial name
- FIGS (NCT07259629)
- Where
- 24 sites in United Kingdom
- Volunteers
- 2,902 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cannabis Use
Investigating Cannabis Use Parameters on Anesthesia and Inflammation in Lumbar Spinal Surgeries
Cannabis is the most commonly used illicit drug in the United States with reported rates of use increasing from approximately 50 million in 2020 to 61.8 million in 2023 among individuals aged 12 or older.
- Trial name
- NCT07354412
- Where
- 2 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Safety Issues
Paracetamol Hypothermia Children
Transient Acetaminophen Induced Hypothermia in Pediatrics Population Undergoing General Anesthesia
- Trial name
- NCT04608669
- Testing
- Paracetamol
- Where
- Lebanon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saint George Hospital
Anesthesia, Spinal
Intrathecal Dexmedetomidine With Bupivacaine for Spinal Anesthesia in Cesarean Section
A Randomized, Controlled, Double blind study aiming to evaluate the analgesic potentials and side effect profile of different dose levels of Dexmedetomidine added to subarachnoid bupivacaine in full-term pregnant women undergoing…
- Trial name
- NCT02365857
- Testing
- Dexmedetomidine & Bupivacaine., Bupivacaine Only.
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Epidural, Labor Pain
Improving Labour Induction Analgesia: Epidural Fentanyl Bolus at Epidural Initiation for Induction of Labour
Labour pain can be intensified for labour inductions and women undergoing inductions often have earlier and more frequent requests for analgesia.
- Conditions
- Epidural, Labor Pain, Induction of Labor Affected Fetus / Newborn, Obstetric Anesthesia Problems
- Trial name
- NCT04011098
- Testing
- Epidural Fentanyl Bolus, Standard Epidural Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Lower Esophageal Sphincter
The Effect of an Opioid on the Lower Esophageal Sphincter During Anesthesia Induction
This study evaluates the effects of adding an opioid (alfentanil) during anesthesia induction with respect to the barrierpressure in the esophagogastric junction.
- Trial name
- NCT01199458
- Testing
- alfentanil, saline
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Lung Injury, Acute
Lung Atelectasis Improvement Through Positive End Expiratory Pressure During Anesthetic Induction
Anesthetic induction could lead to lung atelectasis, increase intrapulmonary shunt, and potentially impair oxygenation. The study aimed to validate that a positive end-expiratory pressure (PEEP) of 10 cmH2O could reduce lung…
- Trial name
- NCT06900426
- Testing
- 10 PEEP, ZEEP, 5PEEP
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fudan University
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Hypotension, Anesthesia
Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension
Background: Spinal anesthesia (SA) is preferred over general anesthesia in Cesarean section (CS) due to its better safety profile but SA induced hypotension remains a big challenge for the clinical Anesthetist.
- Trial name
- NCT05348980
- Testing
- Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Post Induction Hypotension
Dose Responsive Study of Ringer's Lactate Solution in Prevention of Post-induction Hypotension
To assess the dose responsiveness of ringer lactate solution in prevention of post-induction hypotension predicted by Ultrasound guided Inferior Vena Cava diameter in patients receiving General anesthesia.
- Trial name
- NCT05924230
- Testing
- RL 10ml/kg, RL 15ml/kg
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tata Main Hospital
Air Insufflation, Regurgitation
Risk of Gastric Insufflation Related to Facemask Ventilation Technique During Anaesthetic Induction, With or Without PEEP
Continuous positive pressure during anesthetic induction is today not routinely used partly a to the risk of gastric insufflation because of higher ventilatory pressures.
- Trial name
- NCT02238691
- Testing
- Mask ventilation with PEEP via a face mask device
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden