Clinical trials: Anesthesia Induction
Any Patient Under General Anesthesia With Propofol Induction
A Novel Two-Step Dosing Induction Strategy (The Propofol Challenge Test) to Minimize Propofol Injection Pain
Propofol is the most widely used intravenous hypnotic agent for the induction of general anesthesia owing to its rapid onset and short duration of action.
- Trial name
- PROTECT (NCT07763548)
- Testing
- Bolus injection, Fractionned onjection
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Erasme University Hospital
RSI, Rapid Sequence Induction
RSI Observation Follow-up
The purpose of this prospective observational study is to determine if compliance to local guildelines for the RSI procedure, after introduction of a RSI-check list, persists over time (36-60months).
- Conditions
- RSI, Rapid Sequence Induction, Complication of Anesthesia, Compliant Behavior
- Trial name
- NCT05775029
- Where
- 2 sites in Sweden
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Jakob Zeuchner
General Anesthesia Induction for Elective Surgery, Sono Guided Catheterization
Sonographic Safety Margins of Subclavian Vein: Effect of View and Arm Position
The purpose of this observational study is to evaluate and compare the anatomical safety margins of the subclavian vein using ultrasound.
- Trial name
- NCT07556770
- Testing
- Non-invasive sonographic observation
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Asan Medical Center
Anesthesia, Post-induction Hypotension (PIH)
Frequency of Electrical Acupoint Stimulation on Hypotension During Induction
From 15 minutes before to 15 minutes after anesthesia, Transcutaneous Electrical Acupoint Stimulation(TEAS) at different frequencies will be applied at Neiguan and Jian Shi.
- Conditions
- Anesthesia, Post-induction Hypotension (PIH), Transcutaneous Electrical Acupoint Stimulation
- Trial name
- FRESH (NCT07433218)
- Testing
- electrical acupoint stimulation, electrodes pasted, high-frequency electrical stimulation
- Volunteers
- 204 people
- Sponsor
- Zhihong LU
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better…
- Conditions
- Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction, Induction Anesthesia, Coronary Bypass Graft Surgery
- Trial name
- NCT07248202
- Testing
- Fentanyl (IV), lidocaine
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Hypotension on Induction, Frailty
EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery
Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction.
- Conditions
- Hypotension on Induction, Frailty, Anesthesia, General
- Trial name
- PIXEL (NCT07642765)
- Testing
- EASIX Score Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Konya City Hospital
Hemodynamic Instability During Anesthesia, Induction Anesthesia
Low-dose Propofol Plus High-dose Alfentanil in Rapid Sequence Induction
This study compares four different anesthesia induction regimens to see which one provides the most stable blood pressure and heart rate during rapid sequence intubation.
- Conditions
- Hemodynamic Instability During Anesthesia, Induction Anesthesia, Intubation
- Trial name
- NCT07730918
- Testing
- propofol, alfentanil, Sufentanil
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Aoyang Hospital Affiliated to Jiangsu University
Pediatric, Anesthesia Induction
The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding Trial
Ciprofol is a novel intravenous anesthetic with a pharmacological profile similar to propofol but with a lower incidence of injection pain, hypotension, and respiratory depression.
- Conditions
- Pediatric, Anesthesia Induction, Ciprofol, Laryngeal Mask Airway
- Trial name
- NCT07697404
- Testing
- Ciprofol, Fentanyl
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia Induction
Induction in the Dark
This study will enroll children ages 2-6 who are undergoing an elective outpatient surgical procedure under general anesthesia. They will be randomized to one of the following groups and assessed for preoperative anxiety, mask…
- Trial name
- NCT06144177
- Testing
- Dark with star projector, Preoperative midazolam, Parental Presence
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Medical University of South Carolina
Anesthesia Induction
Oxygenation Procedure for Obese Patients During Intubation in the Operating Room
Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during…
- Trial name
- POP-OVNI (NCT06914401)
- Testing
- NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen), NIV (Non Invasive Ventilation)
- Where
- 5 sites in France
- Volunteers
- 124 people
- Sponsor
- Clinique Pasteur
Anesthesia Induction, Propofol Pain Injection
Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.
This is a prospective, single-center, randomized, double-blind controlled trial involving patients scheduled for elective surgery requiring general anesthesia with propofol induction.
- Trial name
- NCT07632144
- Testing
- Group C (Control), Ondansetron 8 mg, Lidocaine %2 ampoule
- Where
- Tunisia
- Volunteers
- 156 people
- Sponsor
- Mongi Slim Hospital
Rapide Sequence Induction, Tracheal Intubation
Pain Assessment During Rapid Sequence Induction
Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception…
- Conditions
- Rapide Sequence Induction, Tracheal Intubation, Nociception, General Anesthesia
- Trial name
- NARSI (NCT07588165)
- Testing
- No Intervention: Observational Cohort
- Where
- Monaco
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Princesse Grace
Post-induction Hypotension (PIH), Hypertension (HTN)
Hemodynamic Effects of Lithotomy Position in Surgical Patients (PH-LITHO)
Anesthesia-induced hypotension is a common occurrence in elderly hypertensive patients and is closely associated with increased postoperative morbidity This study aims to investigate whether the lithotomy position, a…
- Conditions
- Post-induction Hypotension (PIH), Hypertension (HTN), Geriatric Anesthesia
- Trial name
- PIH-LITHO (NCT07549152)
- Testing
- Pre-induction Lithotomy Position, Standard Supine Position
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Trabzon Karadeniz Teknik Universitesi
Pregnancy Related, Cesarean Section Complications
Predictive Hemodynamic Monitoring During Elective Cesarean Section
Single shot spinal anesthesia (SA) is the most commonly used technique for Caesarean section (CS) . SA is associated with maternal hypotension (Post Spinal Hypotension - PSH) often accompanied by nausea, vomiting, bradycardia and…
- Conditions
- Pregnancy Related, Cesarean Section Complications, Hypotension on Induction, Anesthesia Complication
- Trial name
- PREDICTION (NCT06729827)
- Testing
- Hypotension prediction Index - HPI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypotension on Induction, Cardiac Surgery
The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients
This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery.
- Conditions
- Hypotension on Induction, Cardiac Surgery, Antihypertensive Agents, Anesthesia, Intravenous
- Trial name
- NCT07541222
- Testing
- Chronic Antihypertensive Medication Use
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Konya City Hospital
Anesthesia Outcomes, Anesthesia Complication
Does Style of Pre-sedation Instructions Improve Patient Outcomes in Ambulatory Anesthesia for Oral and Maxillofacial Surgery?
This randomized controlled trial aims to evaluate the impact of a brief guided visualization exercise on anesthesia-related outcomes in oral and maxillofacial surgery in patients scheduled for ambulatory anesthesia in the oral…
- Conditions
- Anesthesia Outcomes, Anesthesia Complication, Anesthesia and Procedure Related Time Intervals, Anesthesia Recovery Period
- Trial name
- NCT06768021
- Testing
- Guided visualization and standardized pre-sedation instructions, Standardized pre-sedation instructions only
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Alameda Health System
Labor Pain, Cesarean Delivery Regional Anesthesia Induction
Neuraxial Ultrasound Device Study
The aim of the study is to develop a device that can eliminate failed neuraxial placements in challenging patients.The study will attempt to improve safety and efficacy of neuraxial anesthesia with high precision real-time needle…
- Trial name
- NCT06281249
- Testing
- Ultrasound placement device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Ketamine-dexmedetomidine Induction of Anesthesia
Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Comparative Study
To compare the hemodynamic effects of Ketamine-Dexmedetomidine admixture (Ketodex) versus propofol-ketamine admixture (Ketofol) during induction of anesthesia in elderly
- Trial name
- NCT07002073
- Testing
- Intravenous Induction of Anesthesia
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Cholecystectomy, Laparoscopic, Noise
The Effect of Noise Control During Anesthesia Induction in Laparoscopic Cholecystectomy Surgery
This study aims to determine the effects of active and passive noise control method and headphone usage and noise level during anesthesia induction in laparoscopic cholecystectomy surgery on hemodynamic parameters, pain, nausea…
- Conditions
- Cholecystectomy, Laparoscopic, Noise, Anesthesia Induction
- Trial name
- Anesth-noise (NCT06666686)
- Testing
- Active noise control headphone, Passive noise control headphone
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University