Clinical trials: Anesthesia, active
Aortic Regurgitation Disease, Aortic Insufficiency
Impact of Anesthesia, Positive Pressure Ventilation and Modality of Imaging on the Echocardiographic Assessment of the Severity of Aortic Regurgitation
The goal of this observational study is to assess the impact of imaging modality (trans-thoracic echo (TTE) vs trans-esophageal echo (TEE)), anesthesia and positive pressure ventilation on the grading of aortic insufficiency.
- Trial name
- NCT06835946
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University of Liege
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Anesthesia, Postoperative Pain
Lateral QL Block vs Intrathecal Morphine for Cesarean Section
Effective postoperative analgesia after cesarean delivery is essential for maternal recovery, early mobilization, breastfeeding, and maternal-infant bonding.
- Conditions
- Anesthesia, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT07712783
- Testing
- Lateral Quadratus Lumborum Block, ıv morphine PCA, Intrathecal morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Ondokuz Mayıs University
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Lung Cancer (Diagnosis)
Effect of Apneic Oxygenation of the Non-ventilated Lung During Lung Cancer Surgery.
This study investigates the effect of apneic oxygenation of the non-ventilated lung on local and systemic inflammatory response during lung cancer surgery.
- Trial name
- NCT07393490
- Testing
- Apnoeic Oxygenation, Standard Ventilation
- Where
- Croatia
- Volunteers
- 56 people
- Sponsor
- Osijek University Hospital
Post Operative Analgesia, Regional Anaesthesia
Comparison Between Paravertebral and Erector Spinal Block Efficacy in Robotic Thoracic Surgeries
The overall goal of this work is to find the preferred continues catheter- based thoracic block for patients who undergoing major ROBOTIC assisted thoracic surgery (Lobectomy, multiple segmental resection and thoracotomy).
- Conditions
- Post Operative Analgesia, Regional Anaesthesia, Pain After Surgery, Opioid Consumption
- Trial name
- TPVB vs ESP (NCT07782073)
- Testing
- Paravertebral Nerve Block, ESP block group
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Soroka University Medical Center
Hemorrhoids, Postoperative Pain
Ultrasound-Guided Versus Landmark-Guided Pudendal Block for Post-Hemorrhoidectomy Pain
Hemorrhoid surgery is often followed by significant pain during the first few days after the operation. Pudendal nerve block is a pain-control technique that can help reduce discomfort after surgery.
- Conditions
- Hemorrhoids, Postoperative Pain, Pudendal Nerve Block
- Trial name
- NCT07889869
- Testing
- Ultrasound-Guided Pudendal Nerve Block, Landmark-Guided Pudendal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital
Smart Eyewear
Smart Eyewear to Automatically Detect Drug Delivery Events
This project is designed as a prospective observational study of medication preparation and delivery using a novel wearable data input device to automate detection of drug delivery events in the anesthesia workspace at University…
- Trial name
- NCT05184660
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anesthesia, Endotracheal
Endotracheal Tube (ETT) 180: Stylet-loaded Endotracheal Tube Rotation Before Insertion
The main objective of the proposed study is to clarify whether rotating a stylet-loaded endotracheal tube (ETT) 180 degrees prior to intubation will decrease the incidence of postoperative throat soreness, when compared to…
- Trial name
- NCT06231342
- Testing
- Direct Laryngoscope (DL), Video laryngoscope (VL), Endotracheal Tube (ETT) 180
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Ohio State University
Knee Arthroscopy, Spinal Anaesthesia
Investigation of the Effects of Two Different Anaesthesia Methods Applied to Patients Scheduled for Arthroscopic Knee Surgery on the Heart
The study will include 80 patients aged 18-65 years who will undergo elective arthroscopic meniscal surgery. Patients with bleeding disorders, cardiac disease, liver and/or renal failure, arrhythmia and electrolyte imbalance…
- Conditions
- Knee Arthroscopy, Spinal Anaesthesia, Lumbar/Sciatic Block
- Trial name
- NCT07423754
- Testing
- Knee Arthroscopy, Spinal Anaesthesia, Peripheral Nerve Block, Arthroscopic Knee Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Trauma; Complications, Aspiration
Gastric Ultrasound in Pediatric Trauma Patients
Gastric ultrasound has become increasingly utilized to examine volume and quality of gastric contents in the preoperative setting to guide anesthetic management and relay risk of aspiration in both adult and pediatric medicine.
- Trial name
- NCT05330351
- Testing
- Gastric Ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Philadelphia
Acute Kidney Injury, Surgery Complications
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial
This investigator-initiated, pragmatic trial evaluates whether displaying a machine learning (ML)- derived perioperative AKI risk score-alone or paired with an interruptive Best/Our Practice Advisory (BPA/OPA)-improves…
- Conditions
- Acute Kidney Injury, Surgery Complications, Anesthesia
- Trial name
- ML-AKI (NCT07604662)
- Testing
- EHR-Embedded AKI Risk Score, EHR-Embedded AKI Risk Score with Best Practice Advisory
- Where
- United States
- Volunteers
- 25,518 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cranial Neurosurgery
Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery
Patients undergoing cranial neurosurgery face a high-risk postoperative period, particularly during emergence from anesthesia and early recovery in the post-anesthesia care unit (PACU).
- Trial name
- HERO-PACU (NCT07443072)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Postoperative Pain, Hemidiaphragmatic Paresis
Combined Suprascapular and PECS I Blocks Versus Interscalene Block for Shoulder Arthroscopy
Shoulder arthroscopy can cause moderate to severe pain after surgery. An interscalene block is commonly used to reduce this pain, but it may temporarily weaken movement of the diaphragm on the treated side.
- Trial name
- NCT07852754
- Testing
- suprascapular nerve block, PECS I Block, Interscalene Brachial Plexus Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cansu Ofluoğlu
Anesthesia and Neurotoxicity
Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in Children
In this study, we compared the results of the intelligence and behavioral test performed after surgery between the group using sevoflurane and the group receiving dexmedetomidine and remifentanil, in Korean children under 2 years…
- Trial name
- NCT04364945
- Testing
- dexmedetomidine, remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Intraoperative Pain
Sensory Stimuli During Cesarean Delivery
During a cesarean delivery (C-section), most patients are awake and receive spinal or epidural anesthesia to block pain from the lower body.
- Trial name
- PIONEER-MC (NCT07340970)
- Testing
- Patient-initiated request for pharmacological intervention during cesarean delivery
- Where
- Canada
- Volunteers
- 1,005 people
- Sponsor
- University of British Columbia
Perioperative Care, Hemodynamics
ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries.
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines
- Trial name
- IPAMS (NCT06982001)
- Testing
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management, Radial line catheterization
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Chronic Venous Insufficiency, CVI
The Use of Immersive Virtual Reality as a Method of Treating Anxiety and Procedural Pain During Endovenous Laser Ablation (EVLA) of Lower Varicose Veins Under Tumescent Anesthesia
This is a prospective, single-arm, pre-post interventional study designed to evaluate the feasibility, safety, and impact of immersive virtual reality (VR) as an adjunct to tumescent local anesthesia during endovenous laser…
- Trial name
- EVLA+VR (NCT07624929)
- Testing
- VR (VR-Control)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Bydgoszcz University of Science and Technology
Anesthesia
Assessment of Sevoflurane Consumption During General Anesthesia With a Low Fresh Gas Flow Rate of 0.3 L/Min
Driven by industry demands and the need for anesthesia that consumes fewer resources ("green anesthesia"), manufacturers of anesthesia ventilators have developed closed-circuit ventilators.
- Trial name
- FGF 03 (NCT07628231)
- Testing
- None, Pure observatinal study
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
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