Clinical trials: Alzheimer&Amp;#39;s Disease
Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS)
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
Neurodegenerative disorders (NDDs), such as Parkinson¿s disease (PD), Alzheimer¿s disease (AD), Frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are characterized by aggregation and intracellular accumulation…
- Conditions
- Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Alzheimer's Disease (AD)
- Trial name
- NCT06803784
- Testing
- Genetic: whole genome sequencing, whole exome sequencing
- Where
- Italy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Alzheimer's Disease (AD)
Exploration of the Efficacy and Mechanisms of Lymphaticovenous Anastomosis in the Treatment of Alzheimer's Disease
The aim of this clinical trial is to determine whether Lymphaticovenous Anastomosis can treat Alzheimer's disease，in AD patients aged 18-80.he main questions it aims to answer are: 1.
- Trial name
- NCT06706947
- Testing
- Lymphaticovenous Anastomosis
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Luo Xinxin
Alzheimer&Amp;#39;s Disease, Other Dementias
Remote tDCS and Chair Yoga for Chronic Knee Pain in Alzheimer's Patients
This study aims to evaluate the feasibility, acceptability, and preliminary effects of a home-based, remotely supervised intervention combining transcranial direct current stimulation (tDCS) and online chair yoga (OCY) to manage…
- Trial name
- NCT07303998
- Testing
- Active tDCS paired with active online chair yoga
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona
Cognitive Impairment
Radialis PET Imager for the Assessment of Neuritic Amyloid Plaque Burden
The standard or usual workup for cognitive impairment, including Alzheimer's Disease, may include brain amyloid PET with PET/CT or PET/MR imaging.
- Trial name
- Amyloid RPI (NCT06757569)
- Testing
- PET
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University Health Network, Toronto
Healthy Adult Participants
A Clinical Trial to Study Single- and Multiple- Doses of GSM-779690T in Healthy Participants
This is a randomized, double-blinded, placebo-controlled dose escalating first in human study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD) of GSM-779690T.
- Trial name
- NCT07155980
- Testing
- GSM-779690T
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Acta Pharmaceuticals
Alzheimer&Amp;Amp;#39;s Disease, Alzheimer Disease
Large-coil Parietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Alzheimer Disease (AD)
The goal of this clinical trial is to learn if using large-coil (or "deep") repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus and surrounding areas is feasible, tolerable, and potentially efficacious for…
- Conditions
- Alzheimer&Amp;Amp;#39;s Disease, Alzheimer Disease, Dementia Alzheimer Type, Mild Alzheimer&Amp;Amp;#39;s Disease
- Trial name
- PROMIS-AD (NCT06597942)
- Testing
- TMS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Alzheimer Disease, Dementia Alzheimer Type
Cervical Lymphatico-Venous Bypass for Treatment of Alzheimer's Disease - Proof of Concept Study (CLyVeB-AD-1 Study)
Alzheimer's disease (AD), one of the most common causes of dementia in Singapore and the developed world, is a neurodegenerative disorder with high socioeconomic impact. Accumulation of neurotoxic proteins (ie.
- Conditions
- Alzheimer Disease, Dementia Alzheimer Type, Dementia Alzheimer's Type, Alzheimer's Disease
- Trial name
- CLyVeB-AD-1 (NCT06965062)
- Testing
- Deep cervical lymph node to venous bypass (DCLNV-BP)
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Vincent Tay Khwee Soon
Alzheimer&Amp;#39;s Disease (AD)
Clinical Study on Lymphaticovenous Anastomosis（LVA） for the Treatment of Alzheimer's Disease（AD）
The goal of this clinical trial is to explore the safety and efficacy of Lymphaticovenous Anastomosis (LVA) for the Treatment of Alzheimer's Disease (AD). The main questions it aims to answer are: 1.
- Trial name
- LVA; AD (NCT06918145)
- Testing
- Lymphaticovenous Anastomosis
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Primary Progressive Aphasia(PPA)
Speech and Language Interventions for Italian People With PPA
Primary progressive aphasia (PPA) is an umbrella term used to refer to several clinical variants that manifest as an insidious deterioration of speech/language skills, usually due to frontotemporal lobar degeneration and/or…
- Trial name
- PPA-rehab (NCT06739967)
- Testing
- Behavioral Treatment
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Alzheimer Disease
Transcranial Pulse Stimulation. a Potential Treatment for Early Dementia
Alzheimer's Disease (AD) is characterized by the absence of treatments to slow, stop, or reverse its course, with patients finally losing cognitive functions, skills and independence.
- Trial name
- NCT06730438
- Testing
- Transcranial Pulse Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Francesca Pistoia
Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease
Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease
The goal of this pilot study is to test a combination of two non-invasive brain stimulation methods, called iTBS (intermittent theta burst stimulation) and tDCS (transcranial direct current stimulation), in people with…
- Conditions
- Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease, rTMS Stimulation
- Trial name
- NCT06835283
- Testing
- Brain Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
EEG Brain Oscillations, Alzheimer's Disease (AD)
Effects of Endogenous Gamma Light Stimulation on Brain Oscillations in Cognitively-normal Older Adults
This study aims to evaluate the effects of endogenous gamma non-flickering light stimulation on resting-state EEG rhythms and cognitive function in cognitively healthy older adults.
- Conditions
- EEG Brain Oscillations, Alzheimer's Disease (AD), Cognitively Normal Older Adults
- Trial name
- NCT06715995
- Testing
- Gamma Wave Stimulation Table Lamp (Aleddra, Inc., USA)
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Mindfulness for Cognition in Early-stage Alzheimer's Disease
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury), Aging
- Trial name
- NCT06792877
- Testing
- Mindfulness Intervention, Waitlist then mindfulness
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Boston Healthcare System
Alzheimer's Disease (AD)
Using SRT to Improve The Drinking Problem Behavior of Elderly People With Dementia During The Care of Day Care
Objective: To explore the effects of intermittent retrieval training on cognitive function, daily water intake, body weight, total body water, drinking problem behaviors in day care centers, and caregiver distress in day care…
- Trial name
- NCT07086261
- Testing
- Spaced Retrieval Training
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Alzheimer Disease
Holistic Nursing Benefits Cognitive and Psychiatric Symptoms in Alzheimer's Patients
This clinical study aims to evaluate the effects of a holistic nursing (HN) intervention on cognitive function, psychological well-being, and overall health outcomes in patients with Alzheimer's disease (AD).
- Trial name
- NCT06868004
- Testing
- Holistic Nursing
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The First People's Hospital of Jingzhou
Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Infrared Light for Memory Loss in Mild Cognitive Impairment (MCI)
Mild cognitive impairment (MCI) is a transitional risk state that occurs between the normal aging process and Alzheimer's dementia (AD).
- Trial name
- PBMCI-Prime (NCT06618807)
- Testing
- Active tPBM device
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Alzheimer&Amp;#39;s Disease
Phosphorylated Tau Levels in Donated Blood
Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk.
- Trial name
- pTIDB (NCT07157839)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston