Clinical trials: Alteration of Cognitive Function
Substance Use Disorders
Neurobiological Mechanisms of Chess as an Add-On Treatment Against SUD
Neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, CB-CRT) to reduce cognitive deficits in individuals…
- Trial name
- Chess_SUD (NCT04057534)
- Testing
- Standard therapy for AUD plus Chess-based cognitive treatment, Standard therapy for AUD, Standard smoking cessation therapy for TUD plus Chess-based cognitive treatment
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Neck Pain, Whiplash
PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders
Neck pain-associated disorders (NAD) and whiplash-associated disorders (WAD) are major health problems. NAD has a lifetime prevalence of 54%.
- Conditions
- Neck Pain, Whiplash, Pain, Acute, Psychosocial Functioning
- Trial name
- NCT05468684
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 168 people
- Sponsor
- University of applied sciences
Cognitive Change
Decision Making in Video Games
The purpose of this study is to determine whether anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex induces approach motivation, and whether anodal tDCS applied to the right…
- Trial name
- NCT03869489
- Testing
- Anodal left dorsolateral prefrontal cortex tDCS stimulation, Anodal right dorsolateral prefrontal cortex tDCS stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tufts University
Cognitive Changes Due to Organic Disorder (Finding), Dementia
Gerontology Research Programme: The Singapore Longitudinal Ageing Studies (SLAS I & II)
The Gerontology Research Programme (GRP) in the National University Singapore's Department of Psychological Medicine, was formed to coordinate and facilitate the conduct of multi-disciplinary research on in a wide range of…
- Conditions
- Cognitive Changes Due to Organic Disorder (Finding), Dementia, Mild Cognitive Impairment, Frailty
- Trial name
- SLAS (NCT03405675)
- Testing
- SLAS 1, SLAS 2
- Where
- Singapore
- Volunteers
- 6,183 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Breast Cancer, Cognitive Change
Computerized Cognitive Training in Breast Cancer Survivors
For millions of cancer survivors, cognitive impairment is a prevalent, severe, and persistent problem that is associated with other symptoms (depressive symptoms, anxiety and fatigue), poorer work ability, and poorer quality of…
- Conditions
- Breast Cancer, Cognitive Change, Cognitive Impairment, Quality of Life
- Trial name
- NCT05570604
- Testing
- Sweep Seeker, Bird Safari, Jewel Diver
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Overweight and Obesity, Cognitive Change
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to…
- Conditions
- Overweight and Obesity, Cognitive Change, Psychophysiologic Reaction
- Trial name
- NCT06368297
- Testing
- Ketone Monoester Supplementation, Ketogenic diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Macau
Cognitive Change
Vestibular-Based Exercises vs. Calisthenic Exercises for Cognitive Functions
This study was planned to determine the effects of vestibular-based exercises (VBE) and calisthenic-based exercises (CBE) on the cognitive functions of the older individuals.
- Trial name
- NCT05925582
- Testing
- vestibular based exercise program, calisthenic based exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Biruni University
Alteration of Cognitive Function, Ageing
Health Behaviors and Time-of-Day: Older Adult Cognitive Function
This is a single-center, observational study design. Enrolled participants will be typically, healthy older adults. Participants will complete daily computerized measures, in addition to continuously wearing an Actiwatch device.
- Trial name
- OA-TIME (NCT02300272)
- Testing
- Polysomnograph, Actiwatch
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Change
Effect of Alpha Hope Dietary Supplement on Health and Cognitive Performance
The purpose of the present research study is to evaluate the claims about the supplement influencing cognitive function that may impact performance on cognitive task and related biochemical measures.
- Trial name
- NCT05589051
- Testing
- Drink
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Caffeine, Diet, Healthy
Acute Effects of Fitness Drink Formulas on Energy Expenditure and Fat Metabolism
The purpose of this investigation was to examine the acute effects of consuming two different fitness drink formulas on the physiological response at rest and to exercise in healthy men and women.
- Conditions
- Caffeine, Diet, Healthy, Fat Burn, Cognitive Change
- Trial name
- NCT04455009
- Testing
- Fitness Drink Formula
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Depression, Unipolar, Depression Moderate
The Cerebral and Cognitive Changes After Intermittent Theta Burst Stimulation (iTBS) Treatment for Depression
The present project aims to assess the neurocognitive impact of a two-week once-a-day regimen of intermittent theta burst stimulation (iTBS) compared to sham iTBS, when targeting the left dorsolateral prefrontal cortex (LDLPFC)…
- Trial name
- NCT06534684
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Breast Cancer, Chemotherapy Effect
Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy
The purpose of this research is to determine whether a 16-week high intensity interval training (HIIT) exercise program will improve brain health among women undergoing chemotherapy and also improve cardiovascular (heart)…
- Conditions
- Breast Cancer, Chemotherapy Effect, Exercise Therapy, Cognitive Change
- Trial name
- CLARITY (NCT04724499)
- Testing
- High-Intensity Intervals Training, Attention Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Multiple Sclerosis, Physical Activity
Exercise and Learning and Memory in Multiple Sclerosis
The two primary study objectives involve examining the effects of treadmill walking exercise training versus stretching-and-toning activities on the primary and secondary outcomes.
- Conditions
- Multiple Sclerosis, Physical Activity, Memory Impairment, Cognitive Change
- Trial name
- NCT03319771
- Testing
- Treadmill Walking Exercise Training, Stretching-and-toning Exercise Training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Change
Semaglutide and Cognition in Healthy Volunteers
Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1RA). It is a safe medication approved for use in type-2 diabetes mellitus (T2DM) and obesity.
- Trial name
- OxSENSE (NCT06363487)
- Testing
- Semaglutide, 0.5 mg/mL
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cognitive Change
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults
The present study investigates how individual differences in cognitive processing contribute to the efficacy of working memory training programs in an older adult population.
- Trial name
- NCT05396586
- Testing
- N-back, Span, Multisensory
- Where
- 2 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Schizophrenia and Related Disorders, Sleep Disturbance
SPARK Healthy Sleep
SPARK-Healthy Sleep is a digital mental health intervention designed to help college students who may be at risk for psychosis and experience sleep problems.
- Trial name
- SPARK (NCT07119268)
- Testing
- SPARK Healthy Sleep
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid Use, Cognitive Change
Cognitive Functioning in Opioid Use Disorder
This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning.
- Conditions
- Opioid Use, Cognitive Change, Opioid-use Disorder
- Trial name
- NCT05001789
- Testing
- CogMed
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Cognitive Change
Impact of Challenging Engagement on Cognition in Older Adults
The study will enroll 90 participants in the "Impact of Challenging Engagement" study and assign them to one of three groups: high-demand photography, moderate-demand photography, and active placebo.
- Trial name
- engAGE (NCT03962439)
- Testing
- High-Demand Photography, Moderate-Demand Photography, At-Home Engagement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Breast Cancer
Exercise Program in Cancer and Cognition
This randomized control trial will examine whether a well-controlled and monitored exercise intervention improves cognitive function in postmenopausal women with early-stage breast cancer and will explore whether neuroimaging…
- Trial name
- EPICC (NCT02793921)
- Testing
- Moderate-Intensity Aerobic Exercise Intervention
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Pittsburgh
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital