Clinical trials: Adenomas
Flat Colorectal Lesion
Comparison of Flat Colorectal Lesion Detection by Artificial Intelligence-assisted Colonoscopy Versus Endoscopists
The development of artificial intelligence (AI) systems in the field of colorectal endoscopy is currently booming, colorectal cancer being, by its frequency and severity, a real public health problem.
- Trial name
- AIChallengeMed (NCT05942677)
- Testing
- proportion of colorectal lesions
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Malignant Pleural Mesothelioma
Trimodality Therapy for Malignant Pleural Mesothelioma
The role of surgical resection in the management of Malignant Pleural Mesothelioma (MPM) is still controversial. The selection criterion to perform either Extrapleural Pneumonectomy (EPP) or Pleurectomy/Decortication (P/D) is…
- Trial name
- NCT01343264
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- HSK Wiesbaden
Colon Polyps, Colonoscopy
Impact of Artificial Intelligence on Trainee Polyp Miss Rates
Based on prior studies, trainee and practicing gastroenterologists miss pre-cancerous polyps (adenomas and serrated polyps) during colonoscopy.
- Conditions
- Colon Polyps, Colonoscopy, Artificial Intelligence (AI)
- Trial name
- NCT06676930
- Testing
- Colonoscopy With Computer-Aided Detection, Colonoscopy without Computer-Aided Detection
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Northwestern University
Adenoma Miss Rate
Impact of SE of the Proximal Colon on the AMR
.Studies have demonstrated that the second examination of the proximal colon can significantly increase the proximal ADR.This study aimed to determine the impact of second examination of the proximal colon on AMR compared to…
- Trial name
- NCT05712304
- Testing
- second examination of the proximal colon
- Where
- 2 sites in China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Third People's Hospital of Jingdezhen City
Adenoma and/or Adenocarcinoma, Adenoma
Comparison of Adenoma Detection Miss Rates at Colonoscopy Associated With Different Withdrawal Times
The objective of this study is to determine the optimal withdrawal time for colonoscopy. A 6-minute withdrawal time is currently the standard of care but has only been evaluated in an observational fashion.
- Trial name
- NCT01802008
- Testing
- 3-minute withdrawal time, 6-minute withdrawal time
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Thyroid Cancer, Thyroid Nodule
Modified Cormack Lehane Scores Evaluated by Laryngoscopy During Awake Versus Under General Anesthesia
Nowadays, 5-step modified Cormack-Lehane scoring (MCL) system is frequently used in the observation of laryngeal structures by direct laryngoscopy.
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Adenoma
- Trial name
- NCT03826680
- Testing
- Flexible fiberoptic laryngoscopy, Direct laryngoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Malignant Pleural Mesothelioma
A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma
This study will test whether giving nivolumab in combination with pemetrexed and either cisplatin or carboplatin before surgery is a safe and effective approach to treating resectable mesothelioma without delaying surgery.
- Trial name
- NCT04162015
- Testing
- Nivolumab, Pemetrexed, Cisplatin or Carboplatin
- Where
- 7 sites in United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Parathyroid Adenoma, Parathyroid Neoplasms
Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy
This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)'…
- Conditions
- Parathyroid Adenoma, Parathyroid Neoplasms, Parathyroid Hyperplasia, Parathyroid Cancer
- Trial name
- NIRAF (NCT04299425)
- Testing
- NIRAF Detection Technology
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Bowel Preparation Scale, Adenoma Detection Rate
Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation
High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of the dose of Polyethylene Glycol(PEG) on the quality of bowel preparation.
- Trial name
- NCT03356015
- Testing
- 4L Polyethylene Glycol, 3L Polyethylene Glycol
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatic Neuroendocrine Neoplasm
Nimotuzumab in EGFR Highly Expressed Pancreatic Neuroendocrine Neoplasms
The phase II study is performed to assess the efficacy and safety of Nimotuzumab in patients with stage IV pancreatic neuroendocrine neoplasms and EGFR overexpression.
- Trial name
- NCT05316480
- Testing
- Nimotuzumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Fudan University
Pancreatic Cyst, Pancreas Cyst
Feasibility of Molecular Biology in Pancreatic Cyst Tumors
The main objective of the study is to compare the diagnostic accuracy of intra-cystic fluid DNA molecular analysis to standard diagnostics.
- Conditions
- Pancreatic Cyst, Pancreas Cyst, Serous Cystadenoma, Mucinous Cystadenoma
- Trial name
- CYST-GEN (NCT03305146)
- Testing
- Molecular biology analysis of pancreatic intra-cyst fluid
- Where
- 11 sites in France
- Volunteers
- 93 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Advanced Solid Tumor, Advanced Cancer
AMT-151 in Patients With Selected Advanced Solid Tumours
This first-in-human study will evaluate the Maximum Tolerated Dose (MTD) / the Recommended Phase 2 Dose (RP2D), safety, tolerability, anti-tumor activity, pharmacokinetics, pharmacodynamics and immunogenicity of AMT-151, a novel…
- Conditions
- Advanced Solid Tumor, Advanced Cancer, Advanced Carcinoma, Ovarian Cancer
- Trial name
- NCT05498597
- Testing
- AMT-151
- Where
- 9 sites in Australia, China
- Volunteers
- 30 people
- Sponsor
- Multitude Therapeutics Inc.
Mesothelioma
Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers
This research study is evaluating a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma.
- Trial name
- NCT03683680
- Testing
- MPT Test, CLDN15/VIM Test
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer Colorectal
Impact of EDUcation Strategy on Patients With COLorectal CANCER or Advanced Adenoma in the Detection of Colorectal Cancer of Their First-degree Relatives
The relative risk of colorectal cancer (CRC) is increased in first-degree relatives of patients with CRC or advanced adenoma. In the high-risk CCR population defined by a family history at the first stage of CRC or advanced…
- Trial name
- EDUCANCOLAGE (NCT03084133)
- Testing
- Therapeutic Education Strategy
- Where
- 8 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Tours
Psoriatic Arthritis
Diet Interventions in Psoriatic Arthritis
The purpose of this study is to learn whether changing diet impacts psoriatic arthritis (PsA).
- Trial name
- DIPSA (NCT04180904)
- Testing
- Diet 1, Diet 2
- Where
- 2 sites in United States, Canada
- Volunteers
- 92 people
- Sponsor
- University of Pennsylvania
Acromegaly Due to Pituitary Adenoma, Acromegaly
Effects of Pasireotide Lar Therapy on Bone Metabolism
Acromegaly, a chronic condition characterized by growth hormone (GH) and, in turn, insulin-like growth factor-1 (IGF-I) excess, is burdened by a series of systemic and metabolic comorbidities that strongly impair quality of life…
- Trial name
- Pasi-Bone (NCT07179926)
- Testing
- morphometric spine radiography
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Adenoma
Development and Validation of an Artificial Intelligence-assisted Strategy Selection System for Colonoscopy Cleaning
Patients with poor inadequate bowel preparation need to undergo secondary colonoscopy. but the evaluation of intestinal cleanliness is judged by doctors subjectively.
- Trial name
- NCT04444908
- Where
- China
- Volunteers
- 657 people
- Sponsor
- Renmin Hospital of Wuhan University
Colorectal Neoplasms, Colonic Polyp
Effectiveness of Artificial Intelligence-Assisted Colonoscopy for Adenoma Detection in Routine Clinical Practice : a Prospective Multicenter Randomized Trial
This study is a multi-center, randomized controlled trial designed to evaluate whether an artificial intelligence (AI) system can assist endoscopists to improve the detection rate of colorectal adenomas and cancers during…
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma, Colorectal Cancer
- Trial name
- AI-COLOADR (NCT07307547)
- Testing
- AI-Assisted Colonoscopy
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colon Cancer
The AID Study 2: Artificial Intelligence for Colorectal Adenoma Detection 2
Colonoscopy is clinically used as the gold standard for detection of colon cancer (CRC) and removal of adenomatous polyps. Despite the success of colonoscopy in reducing cancer-related deaths, there exists a disappointing level…
- Trial name
- NCT04260321
- Testing
- AI
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 700 people
- Sponsor
- Istituto Clinico Humanitas