Clinical trials: Acute Heart Failure (AHF)
Heart Failure, Acute Myocardial Infarction (AMI)
Efficacy and Safety of Early Initiation of Vericiguat in Heart Failure After Acute Myocardial Infarction
Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure.
- Conditions
- Heart Failure, Acute Myocardial Infarction (AMI), Acute Heart Failure (AHF)
- Trial name
- VIC-MI (NCT06812546)
- Testing
- Vericiguat
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
Myocardial Infarction (MI), Heart Failure
Timing of Coronary Angiography in NSTEMI Complicated by Acute HF
Study objectives: To determine the optimal timing of coronary angiography (CAG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated by acute decompensated heart failure (AHF).
- Trial name
- TIMING-AHF (NCT07002164)
- Testing
- Immediate coronary angiography, Delayed coronary angiography
- Where
- 20 sites in South Korea
- Volunteers
- 780 people
- Sponsor
- Chonnam National University Hospital
Acute Heart Failure
Short Stay Unit vs Hospitalization in Acute Heart Failure
The majority of the over one million annual AHF hospitalizations originate from the emergency department. Admitting and re-admitting lower risk AHF patients who don't need prolonged hospitalization may increase their risk for…
- Trial name
- SSU-AHF (NCT03302910)
- Testing
- Short Stay Unit, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 194 people
- Sponsor
- Indiana University
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Acute Heart Failure (AHF)
Acute Heart Failure Registry
To evaluate the clinical utility of quantitative electrocardiography (Quantitative ECG, QCG) by analyzing its associations with clinical characteristics and laboratory findings in patients hospitalized with acute heart failure.
- Trial name
- B-AHF (NCT07601022)
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Jin Joo Park
Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease
Temporary MCS With the iVAC 2L Transaortic Device in High-risk PCI
Patients with coronary artery disease and undergoing high-risk percutaneous coronary intervention (PCI) are at increased risk of hemodynamic instability and poor outcomes.
- Conditions
- Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease, Coronary Artery Disease, Cardiogenic Shock
- Trial name
- POTOK (NCT07149714)
- Testing
- iVAC 2L
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Dyspnea
Systolic Time Intervals in the Diagnosis of Heart Failure in Emergency Departement
the gold standard for the diagnostic of acute heart failure is based on clinical, biological (BNP levels) and echocardiographic findings, but still in some cases, the diagnosis is difficult and requires further investigations.
- Trial name
- STA/AHF (NCT02161445)
- Testing
- the acoustic cardiographic parameters were calculated
- Where
- Tunisia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Acute Heart Failure, Frail Elderly Syndrome
Discharge Planning in Emergency Department for Frail Older With AHF
Objectives: To demonstrate the efficacy of care transition holistic intervention (Multilevel Guided Discharge Planning, MGDP) in reducing 30-day adverse outcomes among frail older patients with acute heart failure (AHF)…
- Trial name
- NCT03696875
- Testing
- Multilevel Guided Discharge Planning, Standard of care
- Where
- Spain
- Volunteers
- 1,260 people
- Sponsor
- F. Javier Martin Sanchez
Myocardial Infarction, Decompensated Chronic Heart Failure
Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions
Patients hospitalized for acute cardiac conditions-including acute myocardial infarction, acute heart failure, pulmonary embolism, arrhythmias, and hypertensive emergencies-represent a heterogeneous population at very high risk…
- Conditions
- Myocardial Infarction, Decompensated Chronic Heart Failure, Acute Heart Failure (AHF), Pulmonary Embolism Acute
- Trial name
- NCT07617376
- Testing
- Influenza vaccination
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Wroclaw Medical University
Heart Failure, Acute Heart Failure
Inferior Vena CAVA and Lung UltraSound-guided Therapy in Acute Heart Failure
Between 25% and 30% of patients hospitalized for acute heart failure (AHF) are readmitted within 90 days after discharge. Mostly due to persistent congestion on discharge.
- Trial name
- CAVAL US-AHF (NCT04549701)
- Testing
- CAVAL US-guided Therapy, Standard of care
- Where
- 2 sites in Argentina
- Volunteers
- 60 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
The FOCUS-ADHF Registry
Acute heart failure (AHF) represents a significant clinical and economic burden due to its impact on patients' quality of life, poor prognosis, and high healthcare costs.
- Conditions
- Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive, Regurgitation, Mitral
- Trial name
- FOCUS-ADHF (NCT06726109)
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 600 people
- Sponsor
- ASL Città di Torino
Heart Failure Acute
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial) burden on the health care system. Treatment often consists of the administration of IV decongestive agents.
- Trial name
- TAILOR-AHF (NCT06092437)
- Testing
- Urine sodium guided diuretic algorithm, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 556 people
- Sponsor
- Zuyderland Medisch Centrum
Acute Heart Failure (AHF)
Electrical Cardiometry in Management of Acute Heart Failure
The goal of this clinical trial is to assess if electrical cardiometry (EC) could help in managing acute heart failure (AHF). The main questions it aims to answer are: 1.
- Trial name
- EC/AHF (NCT06982560)
- Testing
- electrical cardiometry, traditonal methods
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Acute Heart Failure
Efficacy and Safety of corticoSTEROids Added to Standard Therapy in Patients With Acute Heart Failure (STERO-AHF)
STERO-AHF is a pilot, prospective, multicenter, randomized, open-label, controlled study aimed to evaluate the diuretic efficacy and early clinical benefit of corticosteroid therapy administered for 7 days, in addition to…
- Trial name
- STERO-AHF (NCT05809011)
- Testing
- Dexamethasone, Prednisone
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Heart Failure
Comparative Evaluation of the Evolution of Emerging Biological Markers in Patients Hospitalized for Acute Heart Failure According to Conventional Management or Therapeutic Adjustment Via Daily Ultrasound.
This is a bi-centric, prospective randomized study to evaluate the contribution of rapid echocardioscopy at the patient's bedside to improving the prognosis of patients hospitalized for acute heart failure.
- Trial name
- JECICA2 (NCT05297630)
- Testing
- Evaluation of the evolution of biological markers from the biobank.
- Where
- 2 sites in France
- Volunteers
- 169 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Heart Failure
Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure
this study aim to investigate the: association of RAAS polymorphisms and AHF association of MMP 3 and 12 polymorphisms and AHF
- Trial name
- PRA-MMP (NCT02170961)
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Heart Failure
Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
The primary objective of the study is to evaluate the effect of 48 hours of intravenous (IV) omecamtiv mecarbil compared with placebo on dyspnea in subjects with left ventricular systolic dysfunction hospitalized for acute heart…
- Trial name
- NCT01300013
- Testing
- Omecamtiv mecarbil
- Where
- 150 sites in United States, Australia and 17 more
- Volunteers
- 614 people
- Sponsor
- Cytokinetics
Heart Failure, Acute Heart Failure (AHF)
OPTIMUM Study of Remote Patient Monitoring in Ambulatory Heart Failure Care
Heart failure is a leading cause of hospitalization and readmission, particularly among older adults with multiple comorbidities.
- Trial name
- OPTIMUM (NCT07439081)
- Testing
- Satelia® Cardio Remote Patient Monitoring System
- Where
- France
- Volunteers
- 504 people
- Sponsor
- Médipôle Lyon-Villeurbanne
Acute Heart Failure, Emergencies
Risk Stratification Using MEESSI-AHF Scale in ED and Impact on AHF Outcomes
Evaluate the impact the application of the MESSI-AHF scale (a risk stratification scale specifically derived and validated in patients diagnosed with acute heart failure, AHF) in decision making (admission vs.
- Trial name
- MEESSI (NCT05919225)
- Testing
- Risk stratification before decision-making about patient hospitalization or discharge
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people
- Sponsor
- Hospital Clinic of Barcelona