Clinical trials: Acne, active
Acne Vulgaris
Study to Assess Safety, Pharmacokinetics, and Treatment Effect of Cabtreo
This study is to evaluate the safety, pharmacokinetics, and treatment effect for topically applied CABTREO lotion in pediatric participants ages 9 to 11 years, 11 months with Acne Vulgaris.
- Trial name
- NCT07524946
- Testing
- CABTREO is a fixed-combination product of clindamycin phosphate 1.2%/BPO 3.1%/adapalene 0.15%.
- Where
- 15 sites in United States
- Volunteers
- 100 people
- Sponsor
- Bausch Health Americas, Inc.
Acne Scars, Acne Scars - Atrophic
Safety and Efficacy Evaluation of the Radiofrequency Therapeutic Device for the Treatment of Atrophic Acne Scars
The objective of this clinical trial is to evaluate the safety and effectiveness of a radiofrequency treatment device for the treatment of atrophic acne scars.
- Conditions
- Acne Scars, Acne Scars - Atrophic, Acne Scar, Acne Scarring
- Trial name
- NCT07620769
- Testing
- Investigational Device with the function deactivated, Investigational Device with the function activated, Control Device
- Where
- 4 sites in China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- CLASSYS Inc.
Acne Vulgaris, Acne Vulgaris on the Face
Study of New Antiandrogenic Progestogen + Low-dose Estrogen for Moderate Acne Vulgaris
This Phase III randomized, double-blind, placebo-controlled, adaptive, multicenter study evaluates the efficacy and safety of a new concentration of the fixed-dose combination EF190 in women with moderate acne vulgaris over six…
- Trial name
- PANDORA (NCT06905210)
- Testing
- Experimental drug (Cyproterone Acetate 2 mg and Ethinyl Estradiol 0.02 mg)
- Where
- 18 sites in Brazil
- Volunteers
- 531 people
- Sponsor
- Eurofarma Laboratorios S.A.
Acne Scars - Atrophic
Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars
To compare the efficacy and safety of combined nanofat injection with either platelet rich fibrin or microneedling versus nanofat injection alone in the treatment of facial atrophic post acne scars.
- Trial name
- NCT07471854
- Testing
- nanofat injecion, Platelet rich fibrin, Microneedling
- Volunteers
- 42 people
- Sponsor
- Assiut University
Acne Vulgaris
Evaluation of Serum Ceramides C16, C24, and Sphingosine-1-Phosphate (S1P) in Patients With Acne Vulgaris
Acne vulgaris is a common chronic inflammatory skin disorder that affects adolescents and young adults. Recent research has shown that lipid mediators, including ceramides and sphingolipids, play an important role in maintaining…
- Trial name
- CER-S1P-ACNE (NCT07250880)
- Testing
- Blood sample collection for biochemical analysis of serum ceramides (C16, C24) and sphingosine-1-phosphate (S1P).
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hair Reduction, Tattoo Removal
Clinical Study to Evaluate the Safety and Efficacy of Candela Technology
This is a non-randomized, multi-center, open-label, prospective clinical study evaluating the clinical treatment with Candela Medical Technology.
- Conditions
- Hair Reduction, Tattoo Removal, Wrinkle, Acne
- Trial name
- NCT06202274
- Testing
- Nordlys, Gentle, Picoway, Vbeam, Profound, Profound Matrix, eTwo, Exceed, CO2RE
- Where
- 3 sites in United States, Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Acne
Phase 1 Study to Evaluate the Safety, Tolerability, PK, and PD of TVB-3567 in Healthy Participants With or Without Acne
This is a 4-part study. Part A will be a randomized, double-blind, placebo-controlled investigation of single ascending doses (SAD) to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) biomarkers of…
- Trial name
- NCT06989840
- Testing
- TVB-3567
- Where
- 6 sites in United States, Australia
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Sagimet Biosciences Inc.
Acne Vulgaris
Cold Atmospheric Plasma for Moderate-to-severe Acne Vulgaris Study
Acne vulgaris is a common, chronic inflammatory skin disease with complex pathogenesis and limited therapeutic options, especially for moderate-to-severe cases.
- Trial name
- NCT07056673
- Testing
- Active CAP therapy, standard care based on the JAAD acne guidelines
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shenyang Medical College
Post-acne Atrophic Scars
Various Procedural Treatment Options for Post-acne Atrophic Scars
Post acne scars are formed as a result of very inflamed and nodulocystic acne. Most common type of acne scars are atrophic scars and they are further classified on the basis of depth and size of destruction into ice pick, boxcar…
- Trial name
- NCT06770608
- Testing
- micro-needling with topical human actrapid insulin, Micro-needling with topical Platelet rich plasma
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Sheikh Zayed Medical College
Acne Vulgaris
Assessment of Serum Catestatin Level in Acne Vulgaris Patients
Acne vulgaris is a persistent inflammatory condition of the pilosebaceous unit, affecting 85% of people between the ages of 12 and 24, it is regarded as one of the most common diseases in teenagers and young adults.
- Trial name
- NCT07054398
- Testing
- Isotretinoin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Acne Vulgaris
Comparing Nadifloxacin Plus Tretinoin Versus Clindamycin Plus Tretinoin Creams for Mild-to-Moderate Acne
The purpose of this randomized controlled trial is to compare the effectiveness of two topical combination treatments for mild-to-moderate acne vulgaris: 1% nadifloxacin with 0.025% tretinoin cream versus 1% clindamycin with…
- Trial name
- NCT07915648
- Testing
- nadifloxacin, Tretinoin Cream 0.025%, Clindamycin
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Nishtar Medical University
Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation
Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color
The investigators aim to investigate the efficacy and tolerability of a hybrid non-ablative/ablative laser for acne scarring in skin of color.
- Conditions
- Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation, Laser-Induced Hyperpigmentation
- Trial name
- NCT05362929
- Testing
- Sciton Halo
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Acne Vulgaris
1% Clascoterone Cream for the Treatment Acne Vulgaris
This is a multicenter, randomized, double-blind, parallel, placebo-controlled Phase III clinical study to evaluate the efficacy and safety of 1% Clascoterone Cream in the treatment of acne vulgaris.
- Trial name
- NCT07457294
- Testing
- 1% Clascoterone Cream
- Volunteers
- 692 people
- Sponsor
- Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd.
Hidradenitis Suppurativa
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa (RECHARGE 1)
The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).
- Trial name
- NCT06799000
- Testing
- Remibrutinib Dose A, Remibrutinib Dose B
- Where
- 139 sites in United States, Argentina and 18 more
- Volunteers
- 588 people
- Sponsor
- Novartis Pharmaceuticals
Hidradenitis Suppurativa (HS)
1726-nm Laser for Acne Inversa (Hidradenitis Suppurativa)
Hidradenitis suppurativa (HS) is a long-lasting skin condition that causes painful lumps, abscesses, and tunnels in areas such as the armpits and groin.
- Trial name
- WMCREI (NCT07155239)
- Testing
- AviClear Lase Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wynn Medical Center
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Efficacy and Safety of Secukinumab in Conjunction With Surgery in Moderate to Severe Hidradenitis Suppurativa
This study aims to retrospectively analyze the efficacy and safety of secukinumab combined with surgery in treating moderate to severe HS in real-world clinical practice, providing clinical practioners with real-world evidence in…
- Conditions
- Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa), Secukinumab
- Trial name
- NCT06926192
- Testing
- Surgery combined with secukinumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College
Cicatrix
A Pilot Study Testing Fractional Radiofrequency Versus Fractional Photothermolysis for the Treatment of Acne Scars
The purpose of this study is to compare the effectiveness of the ePrime fractional radiofrequency system to the 1550-nm fractional photothermolysis system (Fraxel) in the ability to improve acne scar appearance.
- Trial name
- NCT01976260
- Testing
- Fractional Radiofrequency, 1550-nm Fractional Photothermolysis
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Post-inflammatory Hyperpigmentation, Post-acne Hyperpigmentation
Evaluating a Brightening Serum for Post-Inflammatory Hyperpigmentation
This study is designed to evaluate the effectiveness and safety of Vinoperfect, a skin-brightening serum, for treating post-inflammatory hyperpigmentation (PIH), or dark spots that can develop after acne, in participants with…
- Trial name
- NCT07896486
- Testing
- Vinoperfect brightening serum
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Post Acne Scars
Comparison of Efficacy of 35% Glycolic Acid vs 20% Salicylic Acid Peel in the Treatment of Post Acne Scars
The goal of this clinical trial is to compare the effectiveness of two drugs in patients that presents with scars on face after acnes. The effectiveness will be measured by a goodman and baron scale.
- Trial name
- NCT06943118
- Testing
- Chemical Peels
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Hayatabad Medical Complex
Atrophic Acne Scarring
Poly-L-Lactic Acid in Atrophic Acne Scars
Background: Management of atrophic acne scars remains challenging due to their heterogeneous morphology and suboptimal response to conventional therapies.
- Trial name
- NCT07523217
- Testing
- injectable PLLA, PLLA threads
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zagazig University