Clinical trials: Abdominoperineal Resection
Rectal Cancer
Comparison of Sphincter Preservation Surgery and Abdominoperineal Resection (APR): Prospective Clinical Trial
Sphincter preservation surgery in low rectal cancer has been increased due to better understanding of tumor biology and advances in surgical technology.
- Trial name
- ASPIRE (NCT01461525)
- Testing
- Abdominoperineal resection, Sphincter preservation surgery
- Where
- 6 sites in South Korea
- Volunteers
- 342 people
- Sponsor
- Seoul National University Hospital
Rectal Cancer
Quality of Life After Abdominoperineal Resection for Rectal Cancer, Comparing Two Surgical Techniques
The purpose of the study is to compare self-reported health related quality of life after two different operating techniques for low rectal cancer operated by rectal amputation, using a specific and detailed questionnaire.
- Trial name
- APR (NCT01323166)
- Testing
- Excision of the levator muscle
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer, Abdominoperineal Resection
APEMESH- Preventing Perineal Complications After Abdominoperineal Resection
Abdominoperineal resection leaves an empty space to be filled by mesh or musculocutaneus flap. Several studies have reported over 30% morbidity with perineal wound healing after abdominoperineal resection.
- Conditions
- Rectal Cancer, Abdominoperineal Resection, Wound Heal
- Trial name
- NCT04334421
- Testing
- Composite mesh
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Elisa Mäkäräinen
Rectal Cancer
Conventional Laparoscopic APR Versus Laparoscopic APR With Transabdominal Individualized Levator Transection
This study is designed to compare the short-term and long-term benefits between conventional laparoscopic abdominoperineal resection (APR) and laparoscopic APR with transabdominal individualized levator transection (TILT).
- Trial name
- NCT02812628
- Testing
- LAPR, LAPR-TILT
- Where
- China
- Volunteers
- 528 people
- Sponsor
- Ruijin Hospital
Adenocarcinoma of the Rectum, Adenocarcinoma
Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks
The aim of this study is to determine whether greater rectal cancer downstaging and regression occurs when surgery is delayed to 12 weeks after completion of radiotherapy/chemotherapy compared to 6 weeks.
- Conditions
- Adenocarcinoma of the Rectum, Adenocarcinoma, Adenocarcinoma, Mucinous, Carcinoma
- Trial name
- NCT01037049
- Testing
- Patients who have surgery at 12 weeks after radiotherapy/chemoradiotherapy
- Where
- 23 sites in Brazil, Canada and 2 more
- Volunteers
- 237 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Rectal Cancer
Conventional Versus Individual Extralvator Abdominoperineal Excision for Advanced Lower Rectal Cancer
An alternative treatment for low rectal cancer is the extralevator abdominoperineal excision (ELAPE) technique. We aim to compare the outcomes of patients undergoing conventional ELAPE versus Individual ELAPE.
- Trial name
- ELAPE (NCT02036112)
- Testing
- conventional ELAPE, Individual ELAPE
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
Rectal Cancer
Effect of a Post-operative Protocol of Early Mobilization on Functional Recovery and Postoperative Complications After Immediate Internal Pudendal Artery Perforator Flap Reconstruction for Irradiated Abdominoperineal Resection Defects: a Prospective, Randomized and Controlled Clinical Study.
Major abdominal oncology surgery is associated with substantial postoperative loss of functional capacity, and exercise may be an effective intervention to improve outcomes.
- Trial name
- NCT04795609
- Testing
- Early mobilization strategy adapted after immediate internal pudendal artery perforator flap reconstruction for abdominoperineal resection (intervention group).
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Rectal Cancer
Protocol: Reconstruct the Pelvic Peritoneum Using BPF
Background: Extralevator abdominoperineal excision (ELAPE) may cause various surgical complications including disruption of perineal wound, perineal hernia and adhesive small-bowel obstruction.
- Trial name
- PPRBPF (NCT04177407)
- Testing
- Standard laparoscopic ELAPE with pelvic peritoneal floor reconstruction using bladder peritoneum flap are to performed.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- West China Hospital
Hernia, Colostomy Stoma
Prophylactic Funnel Mesh to Prevent Parastomal Hernia in Permanent End Colostomy After Abdomino-perineal Resection
This retrospective study asses if a prophylactic, funnel-shaped, intraperitoneal mesh prevents parastomal hernia in patients undergoing abdominoperineal rectum resection with permanent end colostomy.
- Trial name
- NCT04793009
- Testing
- funnel-shaped, intraperitoneal mesh placement
- Volunteers
- 76 people
- Sponsor
- Walter Brunner
Rectal Cancer
Quality of Life of Patients After Rectal Cancer Resection .
Surgical treatment of cancer of the lower rectum by resection and coloanal anastomosis or abdominoperineal resection in both cases exposes the patient to significant functional digestive sequelae (anal incontinence or permanent…
- Trial name
- QRAAP (NCT07764120)
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
Rectal Cancer
Oncological and Functional Result of AbdominoPerineal Extra Levator Resection for Distal Rectal Cancer
The aim of the project is to evaluate the oncological and functional outcome of the more extensive perineal dissection - i.e the extra levator resection - in abdominoperineal resections in patients with rectal cancer.
- Trial name
- APER (NCT01296984)
- Where
- Sweden
- Volunteers
- 1,319 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer, Defect of Floor of Lesser Pelvis
Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer
The trial compares two different techniques for reconstruction of the lesser pelvic floor after an extended abdominoperineal excision for locally advanced rectal cancer.
- Trial name
- NEAPE (NCT01347697)
- Testing
- Reconstruction with an acellular porcine dermal collagen implant (biological mesh), Reconstruction with a gluteus maximus myocutaneous flap
- Where
- 8 sites in Finland, Sweden
- Volunteers
- 91 people
- Sponsor
- Umeå University
Rectal Cancer
Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer
Rationale: Approximately 800 abdominoperineal resections (APR) are performed for rectal cancer each year in the Netherlands. The extralevator approach (eAPR) reduces the rate of positive margins and improves oncological outcome…
- Trial name
- BIOPEX (NCT01927497)
- Testing
- Biological mesh assisted perineal closure, Primary perineal closure
- Where
- Netherlands
- Volunteers
- 104 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rectal Cancer, Sphincter Ani Incontinence
Hartmanns Procedure or Abdominoperineal Excision With Intersphincteric Dissection in Rectal Cancer: a Randomized Study
In patients with rectal cancer, an anterior resection with a colo-rectal or colo-anal anastomoses is the gold standard. However, in patients with a weak sphincter and fecal incontinence or in patients with severe co-morbidity and…
- Conditions
- Rectal Cancer, Sphincter Ani Incontinence, Other Diagnoses, Comorbidities, and Complications
- Trial name
- HAPIrect (NCT01995396)
- Testing
- APE with intersphincteric dissection, Hartmann´s procedure
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Region Västmanland
Rectal Cancer, Quality of Life
Quality of Life in RECTal Cancer - a Prospective Multicenter Cohort Study
Rectal cancer is a common type of cancer occuring more frequently in men but also common in women. Almost 60% of the patients survive 5-years and the treatment has been continuously developed in the last three decades.
- Conditions
- Rectal Cancer, Quality of Life, Surgery
- Trial name
- QoLiRECT (NCT01477229)
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Sahlgrenska University Hospital
Locally Advanced Rectal Cancer, Abdominoperineal Resection
Inflammation After Laparoscopic Robot-assisted Surgery for Locally Advanced Rectal Cancer
The intention of the study is to explore metabolic and inflammatory parameters in the pelvis and systemically after abdominoperineal resection (APR) for locally advanced rectal cancer (LARC) in patients that have received…
- Trial name
- APR-IMM (NCT04324567)
- Where
- Norway
- Volunteers
- 55 people
- Sponsor
- Oslo University Hospital
Rectal Adenocarcinoma
Extralevator Versus Standard Abdominoperineal Resection For Rectal Adenocarcinoma
This is a study that compares two types of surgery for rectal cancer. There are two procedures that can be used during this surgery, conventional abdominal resection (APR) and extended (or extralevator) APR.
- Trial name
- NCT01702116
- Testing
- extralevator APR, APR
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Stony Brook University
Rectal Cancer, Treatment
Safety and Efficacy Study of Cylindrical Abdominoperineal Resection to Treat Rectal Cancer
The purpose of this study is to determine whether cylindrical abdominoperineal resection is effective in the treatment of advanced very low rectal cancer
- Conditions
- Rectal Cancer, Treatment, Postoperative Complications, Neoplasm Recurrence, Local
- Trial name
- NCT00949273
- Testing
- cylindrical abdominoperineal resection
- Where
- 7 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Rectal Cancer
Exosomes in Rectal Cancer
The primary aims of this study is to characterize exosomal biomarker levels in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation therapy.
- Trial name
- NCT03874559
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Rectal Cancer
Perineal Reconstruction Following eLAPE and Simultaneous Stoma Sublay Reinforcement
This is a prospective, multicenter, single arm, observational pilot study to assess the clinical outcomes of Strattice Reconstructive Tissue Matrix for perineal reconstruction following eLAPE and simultaneous stoma reinforcement.
- Trial name
- PRESSUR (NCT01670851)
- Testing
- Strattice
- Where
- 3 sites in Denmark, Sweden and 1 more
- Volunteers
- 20 people
- Sponsor
- University Hospitals, Leicester