Clinical trials: ARDS, Human
ARDS, Acute Respiratory Distress Syndrome
A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients
The study of positive end-expiratory pressure(PEEP) in the setting mode has not yet been conclusive. there are several ways to choose the best positive end-expiratory pressure(PEEP) mode for ARDS patients.
- Trial name
- NCT03498807
- Testing
- Ventiltor P/V Loop, Electrical Impedance Tomography
- Where
- Taiwan
- Volunteers
- 87 people
- Sponsor
- Hui-Ju Hsu
Acute Respiratory Distress Syndrome, Noninvasive Ventilation
Helmet vs Face Mask in Patients With Acute Respiratory Distress Syndrome
The objective of this study is to evaluate the efficacy of noninvasive ventilation with helmet in reducing endotracheal intubation rates in comparison with Noninvasive Ventilation (NIV) facemask among patients with Acute…
- Conditions
- Acute Respiratory Distress Syndrome, Noninvasive Ventilation, Corona Virus Disease, Acute Respiratory Failure
- Trial name
- NCT04507802
- Testing
- Non invasive ventilation via helmet
- Where
- Qatar
- Volunteers
- 60 people
- Sponsor
- Hamad Medical Corporation
Acute Respiratory Distress Syndrome, ARDS
Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure
This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
- Trial name
- IMPROVENT (NCT03225807)
- Where
- United States
- Volunteers
- 8,692 people
- Sponsor
- Intermountain Health Care, Inc.
Acute Respiratory Distress Syndrome
Long Term Outcome on Brain and Lung of Different Oxygen Strategies in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a serious disease with high mortality. In patients who survive ARDS, respiratory, neurological and motor sequelae are frequent, negatively impacting on the patient's quality of life…
- Trial name
- LTO-BLOXY (NCT03621293)
- Testing
- Modulation of Inspired Fraction of Oxygen (FiO2)
- Where
- France
- Volunteers
- 259 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
ARDS (Acute Respiratory Distress Syndrome)
Pressure Release Ventilation Compared to Lung Protective Ventilation in Moderate and Severe ARDS
This study compares two different ways of providing mechanical ventilation to patients with moderate to severe acute respiratory distress syndrome (ARDS), a serious condition in which the lungs become inflamed and make it…
- Trial name
- NCT07803614
- Testing
- Arm 1 Intervention Name: Low-Tidal-Volume Ventilation (LTV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Koot Ahmad
COVID-19 Acute Respiratory Distress Syndrome, Respiration, Artificial
Flow-controlled Ventilation (FCV) in Moderate Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19
Flow controlled ventilation (FCV) is a fairly new mode of mechanical ventilation, consisting of a constant inspiratory and expiratory flow. Inspiration is thus comparable to volume controlled ventilation (VCV).
- Trial name
- VICAR (NCT04894214)
- Testing
- Arterial blood gas (ABG), Recording of hemodynamic monitoring, Recording of respiratory monitoring
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- University Hospital, Antwerp
ARDS, Respiratory Effort
Comparison of Guiding Sedation Level by Respiratory Effort Versus Usual Care in Mechanically Ventilated Patients: A Randomized Controlled Trial (EFFORT-GUIDE Trial 2)
The objective of this research is to utilize respiratory effort parameters as a tool to assist in adjusting sedative drug levels for patients undergoing mechanical ventilation in the intensive care unit, in comparison to the…
- Conditions
- ARDS, Respiratory Effort, Mechanical Ventilation Complication, Sedation
- Trial name
- NCT06242236
- Testing
- The respiratory effort parameters guide sedative dosage.
- Where
- Thailand
- Volunteers
- 156 people
- Sponsor
- Ramathibodi Hospital
Acute Respiratory Distress Syndrome, Acute Cor Pulmonale
Transpulmonary Pressure in Right Ventricle Protection of ARDS
To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.
- Trial name
- NCT05629832
- Testing
- mechanical ventilation strategy guided by transpulmonary pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Chao Yang Hospital
Adult Respiratory Distress Syndrome, Pneumonia
Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome
The acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure with a mortality rate of approximately 40%.
- Conditions
- Adult Respiratory Distress Syndrome, Pneumonia, Sepsis
- Trial name
- NCT04079426
- Testing
- Sampling of Blood and bronchoalveolar lavage
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Bonn
ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation
Ondansetron for the Prevention of Patient Self-Inflicted Lung Injury in Patients With ARDS - Pilot RCT
Acute Respiratory Distress Syndrome (ARDS) is a serious condition where the lungs become inflamed, leading to severe breathing difficulties.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Invasive Mechanical Ventilation, Patient-Self Inflicted Lung Injury
- Trial name
- OSIRIS-1 (NCT07588217)
- Testing
- Ondansetron hydrochloride 8 mg IV Q8H, 0.9 % Normal Saline 10 ml
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Acute Respiratory Distress Syndrome (ARDS)
Validation of a Semi-automatized Method to Detect Cyclic Hyperinflation on CT-scan in ARDS
This study aims to validate a semi-automatized method to quantify cyclic hyperinflation on CT-scan of ARDS patients. The gold standard will be cyclic hyperinflation assessed on the same CT scan, using manual segmentation of the…
- Trial name
- CT4-ARDS (NCT03870009)
- Testing
- ARDS patients
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
SARS-CoV Infection, COVID 19
The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients
The (World Health Organization) WHO NOR- (Coronavirus infectious disease) COVID 19 study is a multi-centre, adaptive, randomized, open clinical trial to evaluate the safety and efficacy of hydroxychloroquine, remdesivir and…
- Conditions
- SARS-CoV Infection, COVID 19, Acute Respiratory Distress Syndrome ARDS
- Trial name
- NCT04321616
- Testing
- Hydroxychloroquine, Remdesivir, (Standard of Care) SoC
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Oslo University Hospital
COVID-19, Extracorporeal Membrane Oxygenation Complication
Outcome of COVID-19 Patients After Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome
This study aims to investigate outcomes and predictors of outcome after extracorporeal membrane oxygenation (ECMO) therapy for severe acute respiratory syndrome (ARDS) in COVID-19 patients.
- Conditions
- COVID-19, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome
- Trial name
- NCT04383678
- Testing
- Extracorporeal membrane oxygenation
- Where
- 11 sites in Finland, France and 4 more
- Volunteers
- 132 people
- Sponsor
- Helsinki University Central Hospital
Acute Respiratory Distress Syndrome Related to SARS-CoV-2
COronaVirus Induced Acute Respiratory Disease Syndrome During PREGnancy
Few data are available on the management of critically ill pregnant women with pneumonia related to SARS-CoV-2. In the absence of clear recommendations for the management of delivery, clinicians are faced with the risk of…
- Trial name
- COVADIS-PREG (NCT05193526)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High
Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure
Mechanical ventilation can cause damage by overstretching the lungs, especially when the lungs are collapsed or edematous. Raising ventilator pressures can reduce lung collapse and this can prevent overstretching from mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High, Hypoxemic Respiratory Failure
- Trial name
- ALIVE (NCT03589482)
- Testing
- Electrical Impedance Tomography, ExPRESS-derived PEEP level
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Sepsis, Acute Kidney Injury Due to Sepsis
Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction
In the present study, 126 patients were enrolled (23 control, 38 non-septic and 65 septic patients). Blood samples were collected from septic patients at the intensive care unit (ICU) at three time points (T1-3): T1: within 12h…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Septic Shock, Acute Respiratory Distress Syndrome
- Trial name
- NCT05060679
- Testing
- Supportive therapy at the ICU, Sepsis therapy, Sepsis-related organ dysfunction therapy
- Where
- Hungary
- Volunteers
- 126 people
- Sponsor
- University of Pecs
ARDS, ARDS, Human
Efficacy and Safety Evaluation of BZ371B in ARDS Patients
The purpose of this study is to evaluate safety, tolerability and efficacy of BZ371B in intubated patients with severe Acute Respiratory Distress Syndrome.
- Conditions
- ARDS, ARDS, Human, Pulmonary Disease
- Trial name
- NCT05384379
- Testing
- Inhaled BZ371B
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- Biozeus Biopharmaceutical S.A.
Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Explore Potential Plasma and BALF Immunometabolic and Lipidomic Biomarkers for Identifying ARDS Endotypes
Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes high mortality (41% to 58%). Previous studies have reported that biomarkers can facilitate phenotypic diagnosis of ARDS, enabling precision…
- Trial name
- NCT05451342
- Testing
- Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome
The Safety and Dose Response Relationship of Ulinastatin for Acute Respiratory Distress Syndrome(ARDS)
Compared with placebo, evaluate the effects and safety of Ulinastatin(UTI) added to conventional treatment for ARDS; Evaluate the dose response relationship of Ulinastatin for ARDS.
- Trial name
- NCT02895191
- Testing
- ulinastatin
- Where
- 11 sites in China
- Volunteers
- 60 people
- Sponsor
- Techpool Bio-Pharma Co., Ltd.
Acute Necrotizing Pancreatitis, Acute Respiratory Distress Syndrome
Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis
Try to collect about 350 cases of acute necrotizing pancreatitis at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command.
- Trial name
- NCT02641964
- Volunteers
- 350 people
- Sponsor
- Nanjing Medical University
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