Clinical trials: Vaginal Delivery
Infant, Newborn, Diseases, Sepsis
Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn
The purpose of this study is to evaluate whether use of the disinfectant chlorhexidine administered to the birth canal during labour and newborn at delivery can protect a woman and her baby from bacterial infections after birth.
- Conditions
- Infant, Newborn, Diseases, Sepsis, Puerperal Infection
- Trial name
- NCT00136370
- Testing
- Chlorhexidine, Birth canal wipe, sterile water external genital wipe
- Where
- South Africa
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Vaginal Lesion
Abnormal Vaginal Flora and Vaginal Lesions at Delivery: is There a Relationship?
The main objective of this study is to assess whether the presence of abnormal vaginal flora (intermediate flora or vaginosis) is a risk factor for vaginal lesions at the time of delivery.
- Trial name
- NCT01822782
- Testing
- Bacteriological analysis of vaginal sample
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bacterial Vaginosis, Premature Birth
Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
The trial intends to evaluate the efficacy of specially designed probiotics to prevent premature birth and related neonatal morbidity associated to intra-uterine infection.
- Conditions
- Bacterial Vaginosis, Premature Birth, Sepsis, Periventricular Leukomalacia
- Trial name
- NCT00303082
- Testing
- Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
- Where
- 2 sites in Brazil
- Volunteers
- 645 people
- Sponsor
- Oswaldo Cruz Foundation
Placental Blood Drainage
Comparison of Blood Loss in Using vs Not Using Placental Cord Drainage After Spontaneous Vaginal Delivery
Comparison of effectiveness of placental blood drainage after spontaneous vaginal delivery in decreasing the duration, blood loss,and complications of the third stage, against no drainage of placental blood.
- Trial name
- NCT03020355
- Testing
- Placental Blood Drainage, not Placental Blood Drainage
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Preterm Birth
Motherhood and Microbiome
This is a prospective cohort, enriched with women with a prior term birth, of singleton pregnancies who will be followed for the outcome of preterm birth.
- Trial name
- M&M (NCT02030106)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Pennsylvania
Obstetric Labor, Premature
Vaginal Indomethacin for Preterm Labor
Indometacin is a cyclooxygenase agent from the NSAID family that has been used to treat preterm contractions since the 70's by preventing the synthesis of prostaglandins.
- Trial name
- TOCOMED (NCT04404686)
- Testing
- Indomethacin, Nifedipine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Video-Based Breastfeeding Education, Infant Feeding Attitudes
Evaluation of the Effect of Video-Based Breastfeeding Education Provided to Mothers Who Delivered by Cesarean Section and Vaginal Birth on Infant Feeding Attitudes
The purpose of this randomized controlled study is to evaluate the effect of video-based breastfeeding education on infant feeding attitudes among primiparous mothers who delivered by cesarean section or vaginal birth.
- Trial name
- ViBE-IFA (NCT07728045)
- Testing
- Video-Based Breastfeeding Education
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Vaginal Delivery
Postpartum Fatigue and Pain Versus Nutritional Status, With Epidural Analgesia
The objective of this preliminary observational study is to evaluate, in the patient, a correlation between a food habit and nutritional status score of the parturient and a postpartum fatigue (FSS) and pain (ENA) score on day 1…
- Trial name
- NCT05786911
- Testing
- nutritional score
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Charleroi
Cesarean Section
Health Education to Reduce Unnecessary Cesarean Section Among Primigravida Women
This study aims to evaluate the Effectiveness of Health Educational Program for Primigravida Women in Reducing the Rate of Unnecessary Cesarean Section. Specific objectives: 1.
- Trial name
- CS (NCT07810751)
- Testing
- Health Educational Program on Modes of Delivery.
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Labor Onset and Length Abnormalities
Engagement of Fetal Head as a Predictor of a Successful Vaginal Delivery in Primigravidas Presented in Early Labor.
In primigravida, Delayed engagement of fetal head has been theorized that it is more likely in women with a possible cephalo-pelvic disproportion, so far they are associated with higher risk of cervical dystocia, which led to…
- Trial name
- NCT05084326
- Testing
- Engagement of fetal head as a predictor of a successful vaginal delivery
- Where
- Egypt
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- mohamed abosena
Post Partum Hemorrhage
A Pragmatic Randomized Controlled Trial to Predict Postpartum Hemorrhage
This research project aims to enhance the safety of childbirth by using advanced computer models to predict the risk of postpartum hemorrhage (PPH). PPH is a significant concern for mothers during and after delivery.
- Trial name
- NCT06513351
- Testing
- Novel PPH Risk Prediction Model - Comparator Arm B
- Where
- United States
- Volunteers
- 12,500 people
- Sponsor
- Holly Ende
Previous Cesarean Section Scar
Clinical and Ultrasound Score for Evaluation of Previous Cesarean Section Scar
Cesarean delivery rates have increased dramatically worldwide. In the United States, cesarean section (CS) rates increased from 5% of all deliveries in 1970 to a high of 31.9% in 2016.Although efforts were made to reduce the…
- Trial name
- NCT04856254
- Testing
- Trial of labor after cesarean section
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Preterm Labor, Preterm Contractions
Screening To Obviate Preterm Birth
Our objective is to investigate the predictive value of a panel of biomarkers associated with two biologically plausible pathways of preterm birth: membrane breakdown and cervical remodeling.
- Conditions
- Preterm Labor, Preterm Contractions, Abdominal Cramping, Back Pain
- Trial name
- STOP (NCT01868308)
- Where
- United States
- Volunteers
- 589 people
- Sponsor
- University of Pennsylvania
Vesicovaginal Fistula, Delivery of Healthcare
Access to Healthcare, Patient Comprehension and Future Plans of Women Undergoing Surgery for a Vesicovaginal Fistula in Niamey, Niger
Evaluate access to healthcare, comprehension of pre-operative counseling and post-operative goals of women treated for vesicovaginal fistula in Niger through use of a questionnaire.
- Trial name
- NCT00911014
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ascher-Walsh, Charles, M.D.
Preterm Delivery
Efficacy of Oral Progesterone and Vaginal Progesterone After Tocolytic Therapy in Threatened Preterm Labor
The purpose of this study is to determine efficacy of vaginal and oral progesterone after tocolytic therapy in threatened preterm labor
- Trial name
- NCT02989519
- Testing
- dydrogesterone, Micronized progesterone
- Where
- Thailand
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Pregnancy Related, Delivery Complication
Pre-labor Ultrasound as a Visual Biofeedback Device for Maternal Pushing Education
The study will observe the effect of antenatal biofeedback with transperineal and abdominal ultrasound applied by a pelvic floor physical therapist.
- Trial name
- NCT05258786
- Testing
- Pre-labor ultrasound as a visual biofeedback device for maternal pushing education and pelvic floor training
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ariel University
Management of the Second Stage of Labor in Obese Nulliparous Women by Either Passive Descent or Immediate Pushing.
Passive Descent in Obese Nulliparous Gravidae
Obesity rates in reproductive aged women in the United States are rising. It is now universally accepted that obesity is associated with many adverse pregnancy outcomes and post-operative complications following cesarean section.
- Trial name
- NCT02080429
- Testing
- Passive Descent, Pushing
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Pregnancies
Preterm Delivery Prevention in Twins With Progesterone
Twin pregnancies have very high preterm delivery rate. Until now, no RCT has proven benefit of progesterone in this population. In contrast, singleton pregnancies are treated with this hormone.
- Trial name
- NCT01927029
- Testing
- Progesterone
- Volunteers
- 213 people
- Sponsor
- Universidad del Desarrollo
Preterm Birth
Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth
The aim of the study is to determine the effect of cerclage pessary on the incidence of spontaneous delivery between randomization (at 20-24+6 weeks) and 33+6 weeks in asymptomatic women with singleton pregnancies found at…
- Trial name
- NCT00735137
- Testing
- Vaginal pessary (CE0482, MED/CERT ISO 9003 / EN 46003)
- Where
- 24 sites in Austria, Brazil and 10 more
- Volunteers
- 2,109 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Bacterial Vaginosis, Fetal Membranes, Premature Rupture
Perinatal Infections in Pakistan
There are large differences in health outcomes related to pregnancy and birth between developed and developing countries. This study will investigate how infections, medical history, health care behavior and psychosocial issues…
- Conditions
- Bacterial Vaginosis, Fetal Membranes, Premature Rupture, Chorioamnionitis, Pregnancy
- Trial name
- NCT00070746
- Where
- Pakistan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health