Clinical trials: Vaginal Delivery
Vaginal Delivery, Pelvic Organ Prolapse
EASE: The Materna Prep Pivotal Study
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery.
- Trial name
- NCT03973281
- Testing
- Materna Prep Device, Standard of Care (SOC)
- Where
- 22 sites in United States
- Volunteers
- 420 people
- Sponsor
- Materna Medical
Bacterial Vaginosis, Vaginal Dysbiosis
AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm Birth
Preterm birth is a major cause of mortality and long-term disability. Bacterial vaginosis (BV) is a frequent form of dysbiosis that is often asymptomatic and increases the risk of preterm birth.
- Conditions
- Bacterial Vaginosis, Vaginal Dysbiosis, Premature Delivery
- Trial name
- AUTOP 2 (NCT06349122)
- Testing
- Vaginal flora abnormalities screening and quantification using molecular biology technique, Azithromycin, Ceftriaxone
- Volunteers
- 1,794 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Vaginal Delivery
Practice of Assisted Vaginal Birth in Egypt
In Egypt, the proportion of CSs has been steadily increasing in recent years and has reached an alarming level. According to data from the Royal College of Obstetricians and Gynaecologists (RCOG), approximately 6% of caesarean…
- Trial name
- NCT07308977
- Testing
- Survey using a questionnaire.
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Perineal Injury, Perineal Pain
TECAR in the Management of Early Postpartum Perineal Pain.
The study aimed to evaluate the effect of TECAR (Capacitive and Resistive Energy Transfer) therapy on the level of pain and discomfort in the pelvic floor in women after an episiotomy or perineal tears, during the first two days…
- Conditions
- Perineal Injury, Perineal Pain, Vaginal Delivery, Instrumental Delivery
- Trial name
- NCT07730372
- Testing
- TECAR - Capacitive and Resistive Energy Transfer
- Where
- Poland
- Volunteers
- 182 people
- Sponsor
- Medical University of Gdansk
Vaginal Delivery
Bionic Balloon-assisted Delivery Technology on the Labor Process
This multicenter, prospective, randomized controlled trial will evaluate the efficacy and safety of bionic balloon-assisted delivery technology in nulliparous women planning vaginal delivery.
- Trial name
- NCT07707804
- Testing
- Bionic Balloon-assisted Delivery, Routine Labor Management
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Labor, Second Stage, Vaginal Delivery
USE OF PERINEAL MIRROR DURING THE SECOND STAGE OF LABOR
Objective: This study was designed to evaluate the effect of perineal mirror use during the second stage of labor on the duration of the second stage, postpartum recovery, and perceived pain, support, and control levels during…
- Conditions
- Labor, Second Stage, Vaginal Delivery, Primiparity, Perineal Mirror Use
- Trial name
- NCT07659249
- Testing
- Perineal Mirror
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Induction of Labor, Vaginal Delivery
Efficacy and Safety of Oral Misoprostol 25 μg vs. Vaginal Dinoprostone in Induction of Labor at Term
Labor induction is a common medical technique. There is no consensus on which technique is better than the others. Misoprostol is an analogue of Prostaglandin E1 previously used off-label in labor induction.
- Conditions
- Induction of Labor, Vaginal Delivery, Cesarean Section
- Trial name
- MISODINO (NCT04955847)
- Where
- France
- Volunteers
- 706 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Vaginal Laceration During Delivery
The PAIN (Pelvic Area Injection for Numbness) Study
Postpartum pain can interfere with patient's ability to care for themselves, and their newborn, and untreated pain is associated with risk of greater opioid use, postpartum depression, and development of persistent pain.
- Trial name
- PAIN (NCT05972681)
- Testing
- Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Vaginal Laceration During Delivery
Prospective Study Comparing Two Classification Systems for Second-degree Vaginal Tears During Spontaneous Childbirth to Assess Their Ability to Predict Postpartum Complications.
The goal of this observational study is to learn whether different classification systems for second-degree perineal tears can predict postpartum complications in women undergoing spontaneous vaginal childbirth.
- Trial name
- LAC-VAG-2025 (NCT07124676)
- Where
- Italy
- Volunteers
- 482 people
- Sponsor
- University of Campania Luigi Vanvitelli
Surgical Site Infection Prevention, Episiotomy Infection
Effect of Topical Diltiazem Plus Fusidic Acid Versus Fusidic Acid Alone on Episiotomy Healing, Pain, and Resumption of Sexual Activity: A Randomized Controlled Trial in Azadi Teaching Hospital
The goal of this clinical trial is to learn if diltiazem gel combined with fucidic acid cream works better than fucidic acid cream alone to prevent surgical site infection following episiotomy repair.
- Conditions
- Surgical Site Infection Prevention, Episiotomy Infection, Episiotomy Wound, Normal Vaginal Delivery
- Trial name
- NCT07545187
- Testing
- Group 1 received sequential topical diltiazem gel 2% followed by fusidic acid cream, and Group 2 received topical fusidic acid cream alone
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Alaa Nadhim Hameed
Vaginal Delivery, Perineal Tear Resulting From Childbirth
Comparison of Finnish and Viennese Techniques for Perineal Protection in Women During the Second Stage of Labor
The goal of this clinical trial is to find out which method of protecting the perineum during childbirth works better in reducing tears in first-time mothers.
- Trial name
- NCT07537842
- Testing
- Finnish Manual Perineal Protection Technique, Viennese Manual Perineal Protection
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Preterm Spontaneous Labor With Preterm Delivery, Preterm Birth
Synbiotics in Patients at RIsk fOr Preterm Birth
Prematurity remains the main cause of death and serious health problems in new-borns. Besides the need for hospitalization and medical interventions in the first weeks or months of the new-borns' life, prematurity can cause…
- Conditions
- Preterm Spontaneous Labor With Preterm Delivery, Preterm Birth, Microbial Colonization, Microbiome Dysbiosis
- Trial name
- PRIORI (NCT05966649)
- Testing
- Synbiotics
- Where
- 9 sites in Belgium
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
First Pregnancy, Vaginal Delivery
Therapeutic Touch on Labour Pain, Anxiety and Childbirth Attitude
Introduction: Touching ensures physical, emotional and spiritual relaxation, confidence, peace, calmness and well-being, and increases self-esteem.
- Trial name
- touch (NCT04543487)
- Testing
- Therapeutic touch
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Pregnancy, Vaginal Delivery
The Effect of Therapeutic Touch at Birth on Pain, Birth Duration, Traumatic Birth Perception and Anxiety
Aim: This study was planned to determine the effect of therapeutic touch applied at birth on pain, birth duration, traumatic birth perception and anxiety.
- Trial name
- NCT06426329
- Testing
- Therapeutic Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Infant, Newborn, Gut -Microbiota
Infant Microbiota Restoration With Maternal Microbes
The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants.
- Conditions
- Infant, Newborn, Gut -Microbiota, Gut Dysbiosis, Cesarean Delivery Affecting Newborn
- Trial name
- MaMi (NCT07212361)
- Testing
- Probiotic
- Where
- 2 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Normal Vaginal Delivery, Perineal Episiotomy
Effect of Perineal Cryotherapy on Episiotomy
The present study aims to evaluate the effect of perineal cryotherapy on episiotomy- associated pain among postpartum women. The study hypothesis: Post-partum women who apply perineal cryotherapy have lower level of episiotomy…
- Trial name
- NCT06921200
- Testing
- Cryotherapy
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Induced Vaginal Delivery
Tension Versus Tension- Free Foley Balloon for Cervical Ripening
Foley balloons are commonly used as a mechanical method of cervical ripening for induction of labor. Foley balloons may be placed either under tension or without tension (tension-free).
- Trial name
- NCT05404776
- Testing
- Placement of Foley balloon for cervical ripening with tension., Placement of Foley balloon for cervical ripening without tension.
- Where
- United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Vaginal Delivery, Normal Labor
Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
the goal of this randomized control trial is to compare the effect of adding fentanyl v.s dexmedetomidine to bupivacaine in single shot spinal analgesia in achievement of analgesia by decreasing visual analogue scale, onset and…
- Trial name
- SSSA (NCT06823349)
- Testing
- Dexmedetomidine, fentanyl, Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jehan George Sadek
Vaginal Delivery
Outcomes of Delivery in Primigravida
Primigravida women are a high-priority population due to their increased risk of obstetric interventions and adverse outcomes compared to multiparous women.
- Trial name
- NCT07075848
- Testing
- vaginal delivery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Vaginal Breech Delivery Management, Mobile Game
Vaginal Breech Birth Management Educational Mobile Game
Mobile games are used as a powerful learning tool today. It is very useful as it allows students to work on their own frequently when necessary without the need for any physical environment or trainer and can be easily…
- Trial name
- NCT05551611
- Testing
- Playgroup, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University