Clinical trials: Status Epilepticus
Seizure
Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures
Convulsive prolonged seizures in children are the most common life-threatening neurological emergencies. The aim of active management of seizure control is to prevent irreversible neuronal damage as early as possible.
- Trial name
- NCT07098728
- Testing
- Levetiracetam IV, Phenobarbital
- Where
- 2 sites in Burma
- Volunteers
- 180 people
- Sponsor
- Ministry of Health and Sports, Myanmar
Epilepsy, Status Epilepticus
Lacosamide Intravenous Injection for Emergency Termination of Status Epilepticus
Status epilepticus (SE) is an acute and critical form of neurological and systemic diseases involving multiple clinical disciplines, with an annual incidence of (20-73) per 100,000 people and a clinical case fatality rate of 20%.
- Trial name
- NCT06966830
- Testing
- Lacosamide (LCM)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Nervous System Diseases
Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Pediatric Patients With Status Epilepticus (Convulsive) in the Community Setting
The purpose of this study is to determine if the investigational treatment, MHOS/SHP615, is safe and effective in children with status epilepticus (SE) (convulsive) in the community setting.
- Trial name
- NCT03336450
- Testing
- SHP615, MHOS/SHP615
- Where
- 23 sites in Japan
- Volunteers
- 3 people
- Sponsor
- Shire
Stereotypical Prolonged Seizures
A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
The purpose of the study is to evaluate the long-term safety and tolerability of Staccato alprazolam.
- Trial name
- NCT05076617
- Testing
- Staccato alprazolam
- Where
- 136 sites in United States, Australia and 10 more
- Volunteers
- 300 people
- Sponsor
- UCB Biopharma SRL
Status Epilepticus, Coma
Rapid-Response EEG in Children With Suspected Status Epilepticus
Seizures are common in children (~350 per 100,000 patients per year) and require immediate medical attention. If the seizure is prolonged (> 5 minutes) it is called status epilepticus and delayed treatment leads to higher risk in…
- Trial name
- RECS (NCT06564662)
- Testing
- Rapid Response EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital at Montefiore
Last Year Medical Student
Use of Cognitive Aid Methods in the Management of Status Epilepticus
This study aims to evaluate whether cognitive aids improve the management performance of sixth-year Emergency Medicine interns during simulated status epilepticus scenarios.
- Trial name
- NCT07603843
- Testing
- Management of status epilepticus with paper cognitive aids, Management of status epilepticus with digital cognitive aids, Management of status epilepticus with no cognitive aid
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ankara University
Altered Mental Status, Generalized Nonconvulsive Seizure Disorder
Putting Electroencephalography (EEG) in the Emergency Department
The aim of the proposed research is to compare the diagnostic accuracy of a portable wireless electroencephalography (EEG) device (Biosignal Micro-EEG) to standard EEG in identifying abnormal EEG patterns (mainly non-convulsive…
- Conditions
- Altered Mental Status, Generalized Nonconvulsive Seizure Disorder, Status-epilepticus
- Trial name
- NCT01355211
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Bio-Signal Group Corp.
Generalized Convulsive Status Epilepticus
Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children
About 40% of children with generalized convulsive status epilepticus (GCSE) are not terminated by first-line benzodiazepines (BDZs), and approximately 50% of BDZ-refractory GCSE are not controlled by second-line antiseizure…
- Trial name
- KLaSSEC (NCT07046611)
- Testing
- Ketamine, Levetiracetam
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Sohag University
Status Epilepticus, Seizure
EEG in In-hospital Patients With Seizure or Altered Mental State
In Kuopio University Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use.
- Conditions
- Status Epilepticus, Seizure, Altered Mental Status
- Trial name
- NCT02383745
- Testing
- Acute EEG with fast EEG electrode
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital
Status Epilepticus, Ketogenic Dieting
Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects.
- Trial name
- NCT05591508
- Testing
- Ketogenic Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Super-Refractory Status Epilepticus
An Open Label, Expanded Access Protocol With SAGE-547 for Super-Refractory Status Epilepticus
This is an open-label, expanded access protocol, designed to offer treatment with SAGE-547 to subjects in SRSE, and to evaluate the efficacy and safety of SAGE-547 administered as a continuous intravenous infusion to these…
- Trial name
- NCT02433314
- Testing
- SAGE-547
- Sponsor
- Supernus Pharmaceuticals, Inc.
Grand Mal Status Epilepticus, Non-convulsive Status Epilepticus
Refractory Status Epilepticus Treatment Study
Identify the most effective dose of valproic acid when used in combination with phenytoin for treatment of patients with refractory status epilepticus, which allow a better clinical course and prognosis of the disease.
- Trial name
- NCT01586208
- Testing
- valproic acid (VPA)
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Universitari de Bellvitge
Status Epilepticus, Ictal-interictal Continuum
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1.
- Conditions
- Status Epilepticus, Ictal-interictal Continuum, Positron-emission Tomography, Perfusion Weighted MRI
- Trial name
- NCT06017973
- Testing
- MRI scan including arterial spin labelling of the brain, CT perfusion scan of the brain, FDG-PET scan of the brain
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Status Epilepticus
Lorazepam for the Treatment of Status Epilepticus or Repetitive Status Epilepticus in Japan
The purpose of this study is to determine the efficacy, safety and pharmacokinetics of Lorazepam on Japanese patients with Status Epilepticus or Repetitive Status Eplilepticus.
- Trial name
- NCT02239380
- Testing
- Lorazepam
- Where
- 20 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Pfizer
Status Epilepticus, Anaphylaxis
Smartphone Apps for Pediatric Resuscitation
Medication errors are common in children. Characteristics of errors during critical situations in the Emergency Department are ill-defined and might be more frequent than previously thought.
- Trial name
- SMARTER (NCT02958605)
- Testing
- Smartphone apps, Handbook
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Status Epilepticus, Dysimmune Encephalopathy
Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis
COLETTE is an interventional study for which blood, cerebrospinal fluid and post-mortem tissues are collected in patients with status epilepticus or epilepsy associated to dysimmune encephalitis as well as in control patients, to…
- Trial name
- COLETTE (NCT04421846)
- Testing
- Blood sampling, cerebrospinal fluid , post-mortem cerebral tissues (NA for the Group 3), Blood sampling, cerebrospinal fluid, stool sampling post-mortem cerebral tissues (NA for the Group 3)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Epilepticus
Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
- Trial name
- RAMPART (NCT00809146)
- Testing
- Intramuscular route of active treatment, Intravenous route of active treatment
- Where
- 17 sites in United States
- Volunteers
- 1,023 people
- Sponsor
- Robert Silbergleit
Status Epilepticus
Seizure Rescue Medication: Caregiver Education in a Simulation Setting
1. Design an educational quality improvement program to assess the most effective educational approach on caregiver seizure RM application.
- Trial name
- NCT03562351
- Testing
- Verbal Instructions Educational Intervention, Video Educational Intervention, Mannequin Educational Intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Grand Mal Status Epilepticus
Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus
This study is a randomized, open label, parallel group,comparing the safety and efficacy of valproate and levetiracetam in patients of age group 1 to 16 years with status epilepticus not responded to phenytoin and benzodiazepines…
- Trial name
- NCT02920060
- Testing
- Intravenous levetiracetam, Sodium valproate
- Volunteers
- 80 people
- Sponsor
- Banaras Hindu University