Clinical trials: Respiratory Viral Infections
COVID-19 SARS-CoV-2 Infection
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
The purpose of the study is to evaluate whether ibuzatrelvir is effective and safe in adults and adolescents with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease.
- Trial name
- NCT06679140
- Testing
- ibuzatrelvir
- Where
- 256 sites in United States, Argentina and 17 more
- Volunteers
- 2,330 people
- Sponsor
- Pfizer
Respiratory Disease, COVID-19
REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
Background: Many adults and some children with COVID-19 or acute respiratory infection become critically ill and need advanced life support in the Intensive Care Unit (ICU).
- Conditions
- Respiratory Disease, COVID-19, Viral Infection
- Trial name
- REVIVe (NCT05246098)
- Where
- 26 sites in Canada
- Volunteers
- 679 people
- Sponsor
- McMaster University
COVID-19 Vaccines
A Study of COVID-19 Vaccine(s) in Children and Adults
The purpose of this study is to learn about the safety and effects of updated COVID-19 vaccines (called BNT162b2) in participants 5 Through 64 Years of Age with risk factors for Severe COVID-19, and Participants 65 Years of Age…
- Trial name
- NCT07798648
- Testing
- BNT162b2
- Where
- 14 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Gastrointestinal Infection, Respiratory Viral Infection
Wells and Enteric Disease Transmission Trial (WET - Trial)
Approximately 40 million people in the US are served by private wells, many of which are untreated. The investigators estimate that 1.29 million cases of gastrointestinal illness (GI) per year are attributed to consuming water…
- Trial name
- NCT04258059
- Testing
- Active household UV water treatment device, Inactive household UV water treatment device
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Temple University
SARS-CoV2 Infection, Influenza Viral Infections
Reducing Respiratory Virus Transmission in Bangladeshi Classrooms
This study will test if affordable air cleaning devices (box fans with a filter attached and/or ultraviolet light lamps) installed in classrooms can reduce the number of viral respiratory illnesses schoolchildren experience.
- Conditions
- SARS-CoV2 Infection, Influenza Viral Infections, Respiratory Viral Infection
- Trial name
- NCT06247059
- Testing
- Box Fan, UV Germicidal Irradiation Lamp Unit, Combined: Box Fan and UV Germicidal Irradiation Lamp Units
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Acute Bronchiolitis, Viral Bronchiolitis
Internal Jugular Vein Respiratory Variability as a Marker of Disease Severity in Infant Bronchiolitis
This prospective observational cohort study evaluates whether respiratory-cycle variation in internal jugular vein (IJV) diameter, measured by point-of-care ultrasound, correlates with clinical disease severity in infants 1-23…
- Conditions
- Acute Bronchiolitis, Viral Bronchiolitis, Respiratory Syncytial Virus Infections
- Trial name
- IJV-BRONCH (NCT07778225)
- Testing
- Point-of-Care Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Eskisehir Osmangazi University
Cystic Fibrosis in Children, Respiratory Bacterial Infection
Viral Infections and Airway Microbiome in Young Children With Cystic Fibrosis
Cystic fibrosis (CF) is the most common hereditary life-threatening condition in Belgium. Because of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) channel, chloride is unable to move to the cell…
- Conditions
- Cystic Fibrosis in Children, Respiratory Bacterial Infection, Respiratory Viral Infection, Inflammation Lungs
- Trial name
- NCT06188988
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Hospital, Antwerp
Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection
Effectiveness of Immunization in Preventing Severe Acute Respiratory Infection RSV in Children Under 6 Months in Bogotá
This study aims to evaluate the real-world effectiveness of two preventive immunization strategies against Respiratory Syncytial Virus (RSV)-associated severe acute respiratory infection in infants less than six months of age in…
- Conditions
- Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection, Bronchiolitis, Viral, Viral Respiratory Tract Infection
- Trial name
- NCT07279298
- Testing
- RSVpreF vaccine (Abrysvo) and Nirsevimab (Beyfortus) or unexposed
- Where
- Colombia
- Volunteers
- 1,097 people
- Sponsor
- Bogotá District Health Secretariat
Upper Resp Tract Infection, Rhinitis Acute
Evaluation of a Hypertonic Seawater Aerosol Therapy Solution in Adults and Children
The purpose of this study is to evaluate the tolerance, the performance and safety of this device, 22‰ Hypertonic seawater aerosol therapy solution in unidose container, to treat adult and peadiatric patients with of upper…
- Conditions
- Upper Resp Tract Infection, Rhinitis Acute, Rhinopharyngitis, Cold Symptom
- Trial name
- AIR (NCT07267689)
- Testing
- Treatment (22‰ Hypertonic seawater aerosol therapy solution)
- Where
- 4 sites in Poland
- Volunteers
- 110 people
- Sponsor
- Laboratoires Gilbert
Diarrhea, Gastrointestinal Infection
Wells and Enteric Disease Transmission
Approximately 40 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per year are attributed to consuming water from…
- Conditions
- Diarrhea, Gastrointestinal Infection, Respiratory Viral Infection, Waterborne Diseases
- Trial name
- WET (NCT04826991)
- Testing
- Active UV Device, Inactive UV Device
- Where
- United States
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Temple University
Viral Respiratory Infection (e.g., Influenza), Bacterial Respiratory Infections
Respiratory Pathogen Distribution During and After the COVID-19 Pandemic
This retrospective observational study aims to evaluate changes in the prevalence and distribution of respiratory pathogens detected by multiplex respiratory polymerase chain reaction (PCR) testing during and after the SARS-CoV-2…
- Trial name
- NCT07601126
- Where
- Turkey (Türkiye)
- Volunteers
- 537 people
- Sponsor
- Hisar Intercontinental Hospital
Respiratory Viral Infection
Study to Assess the Safety and Efficacy of ZX-7101A for Oral Suspension in Chinese Pediatric Participants 2 to 11 Years of Age With Influenza
The goal of this phase III study is to learn if ZX-7101A for oral suspension works to treat uncomplicated influenza in Pediatric Participants aged 2 to 11 years.
- Trial name
- ZX-7101A-214 (NCT07095257)
- Testing
- ZX-7101A for oral suspension, Oseltamivir phosphate for oral suspension
- Where
- 2 sites in China
- Volunteers
- 169 people
- Sponsor
- Nanjing Zenshine Pharmaceuticals
Parainfluenza, Respiratory Viral Infections
A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers
Croup is an illness of young children that is caused by a virus. With this illness, the child has fever, cough, and hoarseness. Although the illness usually gets better in 2 to 4 days, some children may be admitted to the…
- Trial name
- NCT00186927
- Testing
- Sendai virus vaccine
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Acute Respiratory Viral Infection
Clinical Trial of the Efficacy and Safety of Raphamin in the Treatment of ARVI in Children Aged 3-12 Years
Multicenter double-blind placebo-controlled randomized in parallel groups clinical trial.
- Trial name
- NCT06715891
- Testing
- Raphamin
- Where
- 35 sites in Russia
- Volunteers
- 374 people
- Sponsor
- Materia Medica Holding
Respiratory Syncytial Virus Infection, Bronchiolitis
Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants.
- Conditions
- Respiratory Syncytial Virus Infection, Bronchiolitis, Viral Lower Respiratory Tract Infection (LRTI)
- Trial name
- GUT-LUNG RSV (NCT07417657)
- Where
- Vietnam
- Volunteers
- 250 people
- Sponsor
- Phuc Huu Phan
Bronchopulmonary Dysplasia, Preterm Infant Development
PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants
The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks.
- Conditions
- Bronchopulmonary Dysplasia, Preterm Infant Development, Asthma Childhood, Bronchiolitis
- Trial name
- PremaBiom (NCT07411261)
- Testing
- Nasal swab, blood sampling, Mother milk sampling
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Caen
Lower Respiratory Tract Infection, Pneumonia
Reducing Overuse of Antibiotics With Decision Support
Eliminating inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTI) is the central focus of this research.
- Conditions
- Lower Respiratory Tract Infection, Pneumonia, Asthma, Bronchiolitis, Viral
- Trial name
- ROADS (NCT06788093)
- Testing
- ED Clinical Decision Support (CDS-ED), Transitions Clinical Decision Support (CDS-Tr)
- Where
- 3 sites in United States
- Volunteers
- 2,800 people
- Sponsor
- Vanderbilt University Medical Center
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Respiratory Viral Infection
Phase III Clinical Study Evaluating the Safety, Pharmacokinetics, and Efficacy of JKN2301 Dry Suspension in Pediatric Patients Aged 2 to Under 12 Years With Influenza
The goal of this phase III study is to learn if JKN2301 Dry Suspension works to treat uncomplicated influenza in Pediatric Participants aged 2 to 11 years.
- Trial name
- NCT07357051
- Testing
- JKN2301 Dry Suspension, Oseltamivir
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
Respiratory Tract Infections (RTI), Lower Respiratory Tract Infection (LRTI)
Respiratory Infections in Young Children
The goal of this observational study is to learn about the causes, severity, and long-term effects of respiratory tract infections (RTIs) in young children from birth to five years of age in Colombia and Panamá.
- Conditions
- Respiratory Tract Infections (RTI), Lower Respiratory Tract Infection (LRTI), Viral Infections, Cohort Study
- Trial name
- MINERVAL (NCT07249996)
- Where
- 2 sites in Colombia, Panama
- Volunteers
- 1,088 people, healthy volunteers welcome
- Sponsor
- Eduardo Lopez -Medina