Clinical trials: Osteomyelitis
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Bone Infection, Septic Arthritis
BonE and Joint Infections - Simplifying Treatment in Children Trial
This is a multi- centre trial of children with bone and joint infections (BJIs) at eleven major paediatric hospitals in Australia, New Zealand and Ireland.
- Conditions
- Bone Infection, Septic Arthritis, Bone and Joint Infection, Osteomyelitis
- Trial name
- BEST (NCT04538053)
- Testing
- Oral cefalexin only, IV cefazolin or IV flucloxacillin followed by oral cefalexin
- Where
- 11 sites in Australia, Ireland and 1 more
- Volunteers
- 214 people
- Sponsor
- Murdoch Childrens Research Institute
Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute
Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections
The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children.
- Conditions
- Methicillin Resistant Staphylococcus Aureus, Osteomyelitis Acute, Septic Arthritis, Orbital Cellulitis
- Trial name
- NCT06982105
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Osteomyelitis Chronic
EFFICACY AND SAFETY OF ZOLEDRONATE VERSUS PLACEBO ON PAIN AT WEEK 12 IN PEDIATRIC PATIENTS WITH CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory bone disease that primarily affects children and/or adolescents at a median age of 10 years.
- Trial name
- POMREP (NCT07668583)
- Testing
- Zoledronic Acid / Zoledronate 4 MG/100 ML Intravenous Solution, NaCL 0.9% Intravenous Solution
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteomyelitis of Jaw
Management of Medication Related Osteonecrosis of the Jaws With Double Periosteal Flap Closure
20 patients with MRONJ underwent surgical debridement using piezosurgery then closure using double periosteal flap
- Trial name
- NCT07177378
- Testing
- management of medication related osteonecrosis of the jaw
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Infection
Continuous Antibiotic Infusion In Children
Continuous intravenous antibiotic infusion using elastomeric pumps is well established in adult care and has been shown to be effective, safe, and cost-efficient, particularly for beta-lactams and vancomycin.
- Trial name
- NCT07575009
- Testing
- Benzylpenicillin
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Tampere University Hospital
Nasal Neoplasm, Nasal Neoplasm Benign
Prospective Study of Sinonasal and Skull-base Tumours Management
This observational prospective clinical study aims to describe the epidemiology, management and outcome of patients with sinonasal and skull-base pathology (tumours and diseases with malignant clinical characteristics) in a…
- Conditions
- Nasal Neoplasm, Nasal Neoplasm Benign, Skull Base Neoplasms, Skull Base Osteomyelitis
- Trial name
- Sinonasal_Tu (NCT05607888)
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Recurrent Multifocal Osteomyelitis, Pediatrics
Reliability and Validation of the WB-MRI Radiological Score in CRMO
This study evaluates the inter-observer reliability of a standardized WB-MRI scoring system for CRMO and its consistency with the PedCNO clinical score.
- Trial name
- NCT07483853
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Musculoskeletal Infection, Septic Arthritis
Infrared Thermography for Diagnosis of Musculoskeletal Infections
This is a pilot proof of feasibility study to explore the efficacy of High Resolution Infrared Thermographic Imaging (HRTI) to assist with the detection of musculoskeletal infections in children.
- Conditions
- Musculoskeletal Infection, Septic Arthritis, Osteomyelitis/Septic Arthritis
- Trial name
- NCT07388017
- Testing
- High Resolution Thermal Imaging
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Osteomyelitis Chronic, Bone Defects
Pre-Surgery Rehab for a Child With Humeral Head and Shaft Deformity: A Case Report
The goal of this observational study (single-patient case report) is to learn whether a structured pre-operative physical therapy rehabilitation program can improve shoulder function, reduce pain, and improve quality of life in…
- Trial name
- NCT07283302
- Testing
- Transcutaneous Electrical Nerve Stimulation, Low-Level Laser Therapy, Manual Therapy
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Cairo University
Osteomyelitis, Septic Arthritis
Oral-only Antibiotics for Bone and Joint Infections in Children
A nationwide, multicenter, randomized, non-inferiority trial of children with bone and joint infections. The primary objective is to determine if oral-only antibiotics (experimental arm) is non-inferior to initial intravenous…
- Conditions
- Osteomyelitis, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- CHILD@HOME_BJI (NCT04563325)
- Testing
- Oral co-amoxiclav or oral dicloxacillin only, IV ceftriaxon followed by oral co-amoxiclav or oral dicloxacillin
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteomyelitis Acute, Septic Arthritis
Initial Oral Antibiotics for Bone and Joint Infections in Children
Initial oral antibiotic treatment for children and adolescents with uncomplicated bone and joint infections (BJI) has been found non-inferior to initial IV antibiotics in one randomized controlled trial (RCT).
- Conditions
- Osteomyelitis Acute, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- NCT06827496
- Testing
- Oral antibiotic treatment
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Nonbacterial Osteomyelitis, Chronic Recurrent Multifocal Osteomyelitis
CHronic Nonbacterial Osteomyelitis International Registry
The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease…
- Trial name
- CHOIR (NCT04725422)
- Testing
- Methotrexate, Sulfasalazine, Leflunomide
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital
Chronic Recurrent Multifocal Osteomyelitis
Medication Adherence Intervention in Chronic Recurrent Multifocal Osteomyelitis (CRMO)
This project aims to quantify and evaluate rates of non-adherence and barriers to medication adherence in pediatric patients with CRMO followed at Seattle Children's Hospital's robust CRMO program, which is the only clinical…
- Trial name
- NCT06232603
- Testing
- Education of medication management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Seattle Children's Hospital
Osteomyelitis, Infections
Surgical Treatment of Osteoarticular Infections Using Bioactive Bone Substitute
This prospective research project aims to evaluate the effectiveness and clinical outcomes of utilizing antibiotic-impregnated bioactive bone substitute (PerOssal®) in the surgical management of osteoarticular infections.
- Conditions
- Osteomyelitis, Infections, Fracture, Antibiotics
- Trial name
- NCT06402292
- Testing
- OSTEOMYELITIS SURGICAL TREATMENT WITH LOCAL ANTIBIOTICS AND PEROSSAL
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo
Bone Cancer, Chondrosarcoma
Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI
This pilot trial studies the differentiation of bone sarcomas and osteomyelitis with ferumoxytol-enhanced magnetic resonance imaging (MRI).
- Conditions
- Bone Cancer, Chondrosarcoma, Ewing's Sarcoma, Osteosarcoma
- Trial name
- Osteosarcoma (NCT01336803)
- Testing
- Feraheme, Magnetic Resonance Imaging (MRI) scan
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Heike E Daldrup-Link
Musculoskeletal Infection, Acute Hematogenous Osteomyelitis
Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
The purpose of this study is to evaluate the use of a blood test: Karius® plasma-based next-generation sequencing test (Karius Test), to see if we can detect and measure the infection causing agent in children with…
- Conditions
- Musculoskeletal Infection, Acute Hematogenous Osteomyelitis, Septic Arthritis, Osteomyelitis
- Trial name
- KDG-002 (NCT03846804)
- Testing
- Karius Test
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Osteomyelitis
Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis
This study will be applied to evaluate effect of pulsed electromagnetic field on pediatric localized osteomyelitis.
- Trial name
- PEMF (NCT06084754)
- Testing
- pulsed electromagnetic field, Antibiotics
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Fracture, Osteomyelitis
Treatment of Fracture Related Infection in Latin America.
Postoperative bone infection is a severe complication in the treatment of fractures and is more frequent than in elective joint replacement surgeries.
- Conditions
- Fracture, Osteomyelitis, Soft Tissue Injuries, Bone Loss
- Trial name
- NCT05467644
- Testing
- Treatment of Fracture Related Infection
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Manoel Victorino Hospital
Chronic Recurrent Multifocal Osteomyelitis
Chronic Recurrent Multifocal Osteomyelitis - a Bacterial Cause?
Chronic recurrent multifocal osteomyelitis (CRMO) is an immune-mediated chronic inflammatory self- limiting disease with non-suppurative inflammation involving one or multiple bone foci.
- Trial name
- NCT03433287
- Testing
- 18F-NaF-PET/MRI
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet