Clinical trials: Oestrogen
Breast Cancer
Study of Biomarkers in Tissue Samples From Patients With Breast Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01004796
- Testing
- cytogenetic analysis, microarray analysis, mutation analysis
- Sponsor
- University of Wisconsin, Madison
Postmenopausal Depression, Estrogen
Assessment of the Improvement in Cognitive Levels of Postmenopausal Depression Patients by Estrogen
After menopause, there is a certain tendency towards depression, with the risk of developing depression being about 3 to 4 times higher than before menopause.
- Trial name
- NCT06358014
- Testing
- Fematon (estradiol/estradiol-norethindrone acetate combination tablet package)+SSRIs, SSRIs
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiao Wang
Bone Loss, Breast Cancer
Zoledronic Acid in the Prevention of Cancer Treatment Related Bone Loss in Postmenopausal Women Receiving Letrozole for Breast Cancer.
Post-menopausal breast cancer patients will receive letrozole 2.5 mg daily for the treatment of breast cancer and will be randomized to a treatment group to receive either upfront zoledronic acid 4 mg IV 15-minute infusion every…
- Trial name
- NCT00171340
- Testing
- Zoledronic acid, Letrozole
- Where
- 106 sites in Argentina, Australia and 26 more
- Volunteers
- 1,065 people
- Sponsor
- Novartis Pharmaceuticals
Cystic Fibrosis, Hypoestrogenism
Estrogen Supplementation and Bone Health in Women With CF
The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (CF).
- Trial name
- STURDY (NCT05704036)
- Testing
- Transdermal estrogen, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Overactive Bladder (OAB), Menopause
Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder
The goal of this Pre-Post Quasi-experimental study is to investigates the effect of vaginal estrogen therapy on changes in the urinary microbiome and its association with improvement in overactive bladder (OAB) symptoms in…
- Conditions
- Overactive Bladder (OAB), Menopause, Microbiome
- Trial name
- NCT06780163
- Testing
- 17β-estradiol 10 mcg
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Puberty, Healthy
Negative Emotionality and Epigenetics During Puberty
Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty.
- Conditions
- Puberty, Healthy, Stress
- Trial name
- NCT06690866
- Testing
- Stress
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive
Letrozole and Imatinib Mesylate in Treating Postmenopausal Participants With Estrogen or Progesterone Positive Metastatic Breast Cancer
This phase II trial studies the side effects and how well letrozole and imatinib mesylate work in treating postmenopausal participants with estrogen or progesterone positive breast cancer that has spread to other places in the…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive, KIT Positive, PDGFR Positive
- Trial name
- NCT00338728
- Testing
- Imatinib Mesylate, Letrozole
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Healthy
Susceptibility to Breast Cancer
This study will explore whether different forms, or variants, of genes are related to a person s risk of developing breast cancer.
- Trial name
- NCT00004565
- Where
- United States
- Volunteers
- 737 people
- Sponsor
- National Cancer Institute (NCI)
FHA (Functional Hypothalamic Amenorrhea)
Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Functional Hypothalamic Amenorrhea
The goal of this study is to determine whether romosozumab will improve bone density in girls and women with functional hypothalamic amenorrhea (cessation of the menstrual period due to intense exercise, stress, or an eating…
- Trial name
- NCT06533865
- Testing
- Romosozumab, Zoledronic acid
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Sunitinib Malate and Exemestane in Treating Postmenopausal Women With Breast Cancer
RATIONALE: Sunitinib malate and exemestane may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00931450
- Testing
- exemestane, sunitinib malate
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Institut Català d'Oncologia
Ovarian Failure, Premature
Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure
To directly compare the safety (by laboratory evaluation) and efficacy (feminization and growth) of three commonly used estrogen preparations in adolescent patients with ovarian failure, either due to congenital causes (Turner…
- Trial name
- NCT01023178
- Testing
- 17beta Estradiol, Conjugated estrogens, 17Beta Estradiol - transdermal
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Cardiovascular Diseases, Atherosclerosis
Estrogen Receptor Variants, HDL, and Atherosclerosis
To measure the association between estrogen receptor variants and the extent of atherosclerosis in the thoracic and abdominal aorta and the right coronary artery in subjects in the PDAY study.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Coronary Arteriosclerosis, Heart Diseases
- Trial name
- NCT00081705
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypospadias
Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications
Hypospadias is a congenital abnormality of the penis that is caused by incomplete development of the anterior urethra. This pathology is one of the most common genital anomalies in paediatric urology .The incidence is reported to…
- Trial name
- HYPOSPADES (NCT01370798)
- Testing
- promestriene, Urethroplasty, Wrist X ray
- Where
- 4 sites in France
- Volunteers
- 244 people
- Sponsor
- Hospices Civils de Lyon
Anorexia Nervosa
Effects of Anorexia Nervosa on Peak Bone Mass
Teenage girls with anorexia nervosa (AN) are at risk for low bone density and low rates of bone accrual, raising concerns regarding acquisition of peak bone mass, an important determinant of future bone health and fracture risk.
- Trial name
- NCT01301183
- Testing
- RhIGF-1 with transdermal 17-beta estradiol
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Breast Neoplasms
Aromasin® As Adjuvant Treatment In Postmenopausal Women With Invasive, Estrogen Receptor Positive Early Breast Cancer
This non-interventional study will be conducted in several Eastern European countries to assess the safety, tolerability and efficacy of Aromasin® when it is administered in real-word setting in postmenopausal women with invasive…
- Trial name
- NCT01239745
- Testing
- Aromasin
- Where
- 11 sites in Croatia, Estonia and 1 more
- Volunteers
- 46 people
- Sponsor
- Pfizer
Osteoporosis, Turner's Syndrome
Hormone Replacement Therapy to Treat Turner Syndrome
This study will evaluate the effects of hormone replacement therapy on patients with Turner syndrome (TS)-a genetic disorder in females in which part or all of one X chromosome is missing.
- Trial name
- NCT00013546
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer
Dose Optimization of Rosuvastatin in Early Stage and Metastatic Estrogen Receptor Positive Breast Cancer Patients on Endocrine Therapy
Patients will be treated in a dose escalation scheme to investigate a role for the addition of a statin in the treatment of estrogen receptor positive breast cancer. Patients will take oral rosuvastatin daily.
- Trial name
- NCT02483871
- Testing
- Rosuvastatin
- Where
- United States
- Sponsor
- Duke University
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Diseases, Heart Diseases
Myocardial Infarction and Non-contraceptive Estrogen Use
To evaluate whether the use of noncontraceptive estrogen influenced the incidence of first myocardial infarction in women.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Menopause
- Trial name
- NCT00005185
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Cancer
A Prospective Observational Study of Clinical Outcomes for the NanoString® Technologies Prosigna Gene Signature Assay
The primary objective of this study is to assess the extent to which the Prosigna™ Breast Cancer Prognostic Gene Signature Assay affects the medical oncologist's treatment recommendations regarding adjuvant chemotherapy and…
- Trial name
- NCT01899079
- Where
- 7 sites in Spain
- Volunteers
- 217 people
- Sponsor
- NanoString Technologies, Inc.