Clinical trials: Oestrogen
Hypotension, Cirrhosis
Comparison of the Concentration of Estrogen and Testosterone Ratio in Male Patients With Cirrhosis and Hypotension
Cirrhosis is an end stage in liver disease leading to replacement of normal liver tissue with regenerative nodules surrounded by fibrous bands in response to chronic liver injury.
- Trial name
- NCT05051293
- Testing
- serum concentration of estrogen (E1 and E2) and testosterone ratio measurement
- Sponsor
- Methodist Health System
Breast Cancer Patients in Premenopausal, Estrogen and/or Progesterone Receptor Positive
Efficacy and Tolerability of Toremifene or Tamoxifen Therapy in Premenopausal Estrogen and Progesterone Receptor Positive Breast Cancer Patients
In premenopausal women, endocrine adjuvant therapy for breast cancer primarily consists of tamoxifen alone or with ovarian suppressive strategies.
- Trial name
- NCT02132000
- Testing
- toremifene or tamoxifen
- Where
- China
- Volunteers
- 3,036 people
- Sponsor
- Fengxi Su
Pelvic Organ Prolapse, Menopause
Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor
This is a study to determine how vaginal estrogen cream given for several weeks before pelvic reconstructive therapy will effect elastic fiber assembly in the muscularis layer of the vaginal wall.
- Trial name
- PET (NCT01778985)
- Testing
- Premarin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Metastatic Breast Cancer
ELACESTRANT in Women and Men With CDK4/6 Inhibitor-Naive Estrogen Receptor Positive, HER-2 Negative Metastatic Breast Cancer Study
The purpose of this study is to evaluate the efficacy and safety of elacestrant over the course of 6 months in patients with estrogen receptor positive (ER+)/human epidermal growth factor receptor-2 negative (HER2-)…
- Trial name
- ELCIN (NCT05596409)
- Testing
- Elacestrant
- Where
- 22 sites in United States, Brazil and 4 more
- Volunteers
- 61 people
- Sponsor
- Stemline Therapeutics, Inc.
Sleep Deprivation, Menstrual Cycle
The Effects of Night Shift Work on Health Across the Menstrual Cycle
The study aims to investigate the effects of sleep deprivation on women's health across different phases of the menstrual cycle.
- Conditions
- Sleep Deprivation, Menstrual Cycle, Brain Health, Metabolism
- Trial name
- MENSLEEP (NCT06683248)
- Testing
- Investigate sleep deprivation
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Recurrent Breast Carcinoma, Stage III Breast Cancer AJCC v7
Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer
This randomized phase II trial studies how well tamoxifen citrate works compared with z-endoxifen hydrochloride in treating patients with breast cancer that has spread to nearby tissue or lymph nodes or other parts of the body…
- Conditions
- Recurrent Breast Carcinoma, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7
- Trial name
- NCT02311933
- Testing
- Endoxifen Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 559 sites in United States
- Volunteers
- 81 people
- Sponsor
- National Cancer Institute (NCI)
Healthy
Progesterone Amplifies Estrogen-stimulated Growth Hormone Secretion in Older Women
Progesterone amplifies estrogen-stimulated Growth Hormone (GH) secretion in postmenopausal women. Preliminary data are sought to estimate statistical power for more detailed studies of this hypothesis.
- Trial name
- NCT02272647
- Testing
- IM Estradiol valerate (2.5 mg), IM Estradiol valerate (5.0 mg), Oral Micronized Progesterone
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sleep Initiation and Maintenance Disorders, Depression
Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia
This study will evaluate the effectiveness of estrogen replacement therapy in treating depression in menopausal women with hot flashes and insomnia.
- Trial name
- NCT00227942
- Testing
- Estrogen Replacement Therapy, Zolpidem
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hadine Joffe, MD
Breast Cancer
Study of Biomarkers in Tissue Samples From Patients With Breast Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01004796
- Testing
- cytogenetic analysis, microarray analysis, mutation analysis
- Sponsor
- University of Wisconsin, Madison
Diabetic Macular Edema
Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular Edema
The drug being tested in this study is low doses of Optina (formerly known as Danazol) (DMI-5207) that may be an effective treatment for diabetic retinopathy and diabetic macular edema (DME).
- Trial name
- NCT02002403
- Testing
- Danazol
- Volunteers
- 34 people
- Sponsor
- Unity Health Toronto
Breast Cancer
Phase II Trial of SAHA & Tamoxifen for Patients With Breast Cancer
Phase II trial to explore the efficacy of vorinostat and tamoxifen combined.
- Trial name
- NCT00365599
- Testing
- suberoylanilide hydroxamic acid (SAHA, Vorinostat), tamoxifen citrate (Tamoxifen)
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Postmenopausal Depression, Estrogen
Assessment of the Improvement in Cognitive Levels of Postmenopausal Depression Patients by Estrogen
After menopause, there is a certain tendency towards depression, with the risk of developing depression being about 3 to 4 times higher than before menopause.
- Trial name
- NCT06358014
- Testing
- Fematon (estradiol/estradiol-norethindrone acetate combination tablet package)+SSRIs, SSRIs
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xiao Wang
Menopause
Estrogen Hormone Products
The purpose is to determine if the two estradiol products can deliver similar amounts of estradiol after single and multiple dosing.
- Trial name
- NCT05645406
- Testing
- Divigel 0.1% Topical Gel, Compounded estradiol product
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
Nipple Aspirate Fluid in Detecting Breast Cancer
This trial studies nipple aspirate fluid in detecting breast cancer. Nipple aspirate fluid may better detect breast cancer earlier than current methods used for screening such as mammograms and breast examinations.
- Conditions
- Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
- Trial name
- NCT03715959
- Testing
- Aspiration of Breast, Biospecimen Collection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Bone Loss, Breast Cancer
Zoledronic Acid in the Prevention of Cancer Treatment Related Bone Loss in Postmenopausal Women Receiving Letrozole for Breast Cancer.
Post-menopausal breast cancer patients will receive letrozole 2.5 mg daily for the treatment of breast cancer and will be randomized to a treatment group to receive either upfront zoledronic acid 4 mg IV 15-minute infusion every…
- Trial name
- NCT00171340
- Testing
- Zoledronic acid, Letrozole
- Where
- 106 sites in Argentina, Australia and 26 more
- Volunteers
- 1,065 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Brain Metastases
Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer
The goal of this interventional study is to optimize the protocol of FES PET/CT in Estrogen Receptor positive Breast cancer patients with Brain metastases.
- Trial name
- NCT06072807
- Testing
- Brain Imaging with 18F-FES
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Cystic Fibrosis, Hypoestrogenism
Estrogen Supplementation and Bone Health in Women With CF
The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (CF).
- Trial name
- STURDY (NCT05704036)
- Testing
- Transdermal estrogen, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Estrogen Levels Among Breast Cancer Patients
Estradiol Levels in Patients Treated With Estring
Estrogen receptor positive breast cancer is the most common type of breast cancer and anti-estrogen therapy has been shown to be very effective in preventing recurrence.
- Trial name
- NCT01923298
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Arizona
Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
Mucoadhesive Oral Wound Rinse in Preventing and Treating Stomatitis in Patients With ER- or PR-Positive Metastatic or Locally Recurrent Breast Cancer That Cannot be Removed by Surgery Receiving Everolimus
This randomized phase II trial studies how well mucoadhesive oral wound rinse works in preventing and treating stomatitis in patients with estrogen receptor (ER)- or progesterone receptor (PR)-positive metastatic or locally…
- Conditions
- Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer, Oral Complications, Progesterone Receptor-positive Breast Cancer
- Trial name
- NCT02015559
- Testing
- mucoadhesive oral wound rinse, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Oxytocin, Estrogen
Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin
The study aims to examine a behavioral and neural framework for understanding the sex-specific effects of the neuropeptide oxytocin (OXT).
- Conditions
- Oxytocin, Estrogen, Fear Extinction, Emotion Processing
- Trial name
- ESMory (NCT04330677)
- Testing
- Oxytocin nasal spray, Estrogen Gel
- Where
- Germany
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
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